ID   ARPE-19
AC   CVCL_0145
SY   ARPE19; Adult Retinal Pigment Epithelial cell line-19; NTC-200; NTC200
DR   BTO; BTO:0002335
DR   CLO; CLO_0001749
DR   EFO; EFO_0006271
DR   MCCL; MCC:0000038
DR   ATCC; CRL-2302
DR   BCRC; 60383
DR   BCRJ; 0041
DR   BioSample; SAMN03471862
DR   CCRID; 4201HUM-CCTCC00323
DR   GEO; GSM1227434
DR   Lonza; 871
DR   MetaboLights; MTBLS213
DR   PRIDE; PXD006125
DR   PRIDE; PXD006269
DR   PRIDE; PXD009607
DR   Wikidata; Q28812659
RX   DOI=10.5897/IJBMBR2013.0154;
RX   PubMed=8698076;
RX   PubMed=11504951;
RX   PubMed=14551534;
RX   PubMed=16262907;
RX   PubMed=21697133;
RX   PubMed=24251032;
RX   PubMed=25177495;
RX   PubMed=27499609;
RX   PubMed=28978645;
RX   PubMed=29476476;
RX   PubMed=31254428;
RX   PubMed=31412689;
CC   Doubling time: 55 hours (from cell counting), 65 hours (from absorbance) (DOI=10.5897/IJBMBR2013.0154).
CC   Omics: Deep proteome analysis.
CC   Omics: Deep quantitative phosphoproteome analysis.
CC   Omics: Metabolome analysis.
CC   Omics: Transcriptome analysis.
CC   Misspelling: APRE-19; Occasionally.
CC   Derived from sampling site: Eye; retinal pigment epithelium.
ST   Source(s): ATCC; PubMed=27499609; PubMed=31412689
ST   Amelogenin: X,Y
ST   CSF1PO: 11
ST   D12S391: 21,22
ST   D13S317: 11,12
ST   D16S539: 9,11
ST   D18S51: 12,16
ST   D19S433: 12,13
ST   D21S11: 28,29
ST   D2S1338: 19
ST   D3S1358: 14,15
ST   D5S818: 13
ST   D6S1043: 17,19
ST   D7S820: 9,11
ST   D8S1179: 13
ST   FGA: 23
ST   Penta D: 11,13
ST   Penta E: 7,11
ST   TH01: 6,9.3
ST   TPOX: 9,11
ST   vWA: 16,19
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   19Y
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 23-09-21; Version: 24
RX   DOI=10.5897/IJBMBR2013.0154;
RA   Iloki Assanga S.B., Gil-Salido A.A., Lewis Lujan L.M., Rosas-Durazo A.,
RA   Acosta-Silva A.L., Rivera-Castaneda E.G., Rubio-Pino J.L.;
RT   "Cell growth curves for different cell lines and their relationship
RT   with biological activities.";
RL   Int. J. Biotechnol. Mol. Biol. Res. 4:60-70(2013).
RX   PubMed=8698076; DOI=10.1006/exer.1996.0020;
RA   Dunn K.C., Aotaki-Keen A.E., Putkey F.R., Hjelmeland L.M.;
RT   "ARPE-19, a human retinal pigment epithelial cell line with
RT   differentiated properties.";
RL   Exp. Eye Res. 62:155-169(1996).
RX   PubMed=11504951; DOI=10.1073/pnas.171266298;
RA   Lund R.D., Adamson P., Sauve Y., Keegan D.J., Girman S.V., Wang S.,
RA   Winton H.L., Kanuga N., Kwan A.S.L., Beauchene L., Zerbib A.,
RA   Hetherington L., Couraud P.-O., Coffey P., Greenwood J.;
RT   "Subretinal transplantation of genetically modified human cell lines
RT   attenuates loss of visual function in dystrophic rats.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9942-9947(2001).
RX   PubMed=14551534;
RA   Rogojina A.T., Orr W.E., Song B.K., Geisert E.E. Jr.;
RT   "Comparing the use of Affymetrix to spotted oligonucleotide
RT   microarrays using two retinal pigment epithelium cell lines.";
RL   Mol. Vis. 9:482-496(2003).
RX   PubMed=16262907; DOI=10.1186/1471-2415-5-25;
RA   Sharma R.K., Orr W.E., Schmitt A.D., Johnson D.A.;
RT   "A functional profile of gene expression in ARPE-19 cells.";
RL   BMC Ophthalmol. 5:25.1-25.10(2005).
RX   PubMed=21697133; DOI=10.1167/iovs.11-7479;
RA   Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M.,
RA   Toyama S., Usami R., Ohtoko K., Kato S.;
RT   "Full-length transcriptome analysis of human retina-derived cell lines
RT   ARPE-19 and Y79 using the vector-capping method.";
RL   Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011).
RX   PubMed=24251032; DOI=10.1155/2013/216359;
RA   Pasovic L., Utheim T.P., Maria R., Lyberg T., Messelt E.B., Aabel P.,
RA   Chen D.F., Chen X., Eidet J.R.;
RT   "Optimization of storage temperature for cultured ARPE-19 cells.";
RL   J. Ophthalmol. 2013:216359-216359(2013).
RX   PubMed=25177495; DOI=10.1155/2014/801787;
RA   Kuznetsova A.V., Kurinov A.M., Aleksandrova M.A.;
RT   "Cell models to study regulation of cell transformation in pathologies
RT   of retinal pigment epithelium.";
RL   J. Ophthalmol. 2014:801787-801787(2014).
RX   PubMed=27499609;
RA   Wang Y., Sang A.-M., Zhu M.-H., Zhang G.-W., Guan H.-J., Ji M.,
RA   Chen H.;
RT   "Tissue factor induces VEGF expression via activation of the
RT   Wnt/beta-catenin signaling pathway in ARPE-19 cells.";
RL   Mol. Vis. 22:886-897(2016).
RX   PubMed=28978645; DOI=10.1074/jbc.M117.812677;
RA   Chiang C.-K., Tworak A., Kevany B.M., Xu B., Mayne J., Ning Z.,
RA   Figeys D., Palczewski K.;
RT   "Quantitative phosphoproteomics reveals involvement of multiple
RT   signaling pathways in early phagocytosis by the retinal pigmented
RT   epithelium.";
RL   J. Biol. Chem. 292:19826-19839(2017).
RX   PubMed=29476476; DOI=10.1007/978-1-4939-7680-5_17;
RA   Fasler-Kan E., Aliu N., Wunderlich K., Ketterer S., Ruggiero S.,
RA   Berger S., Meyer P.;
RT   "The retinal pigment epithelial cell line (ARPE-19) displays mosaic
RT   structural chromosomal aberrations.";
RL   Methods Mol. Biol. 1745:305-314(2018).
RX   PubMed=31254428; DOI=10.1111/ceo.13578;
RA   Churm R., Dunseath G.J., Prior S.L., Thomas R.L., Banerjee S.,
RA   Owens D.R.;
RT   "Development and characterization of an in vitro system of the human
RT   retina using cultured cell lines.";
RL   Clin. Exp. Ophthalmol. 47:1055-1062(2019).
RX   PubMed=31412689; DOI=10.3390/pharmaceutics11080412;
RA   Hellinen L., Pirskanen L., Tengvall-Unadike U., Urtti A.,
RA   Reinisalo M.;
RT   "Retinal pigment epithelial cell line with fast differentiation and
RT   improved barrier properties.";
RL   Pharmaceutics 11:412.1-412.12(2019).