Cellosaurus cell line Akata (CVCL_0148)

• Mutation; HGNC; 11998; TP53; Simple; p.Pro190Leufs*57 (c.569delC); ClinVar=VCV000825904; Zygosity=Unspecified (PubMed=1915267).
  

PubMed=1647567; DOI=10.1007/BF00571929
Takada K., Horinouchi K., Ono Y., Aya T., Osato T., Takahashi M., Hayasaka S.
An Epstein-Barr virus-producer line Akata: establishment of the cell line and analysis of viral DNA.
Virus Genes 5:147-156(1991)

PubMed=1915267; DOI=10.1002/j.1460-2075.1991.tb07837.x
Farrell P.J., Allan G.J., Shanahan F., Vousden K.H., Crook T.
p53 is frequently mutated in Burkitt's lymphoma cell lines.
EMBO J. 10:2879-2887(1991)

PubMed=9473234; DOI=10.1182/blood.V91.5.1680
Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Blood 91:1680-1687(1998)

PubMed=9973220
Gutierrez M.I., Cherney B.W., Hussain A., Mostowski H.S., Tosato G., Magrath I.T., Bhatia K.G.
Bax is frequently compromised in Burkitt's lymphomas with irreversible resistance to Fas-induced apoptosis.
Cancer Res. 59:696-703(1999)

PubMed=11559830; DOI=10.1128/JVI.75.20.9977-9982.2001
Maruo S., Nanbo A., Takada K.
Replacement of the Epstein-Barr virus plasmid with the EBER plasmid in Burkitt's lymphoma cells.
J. Virol. 75:9977-9982(2001)

PubMed=23152513; DOI=10.1128/JVI.02517-12
Lin Z., Wang X., Strong M.J., Concha M., Baddoo M., Xu G.-R., Baribault C., Fewell C., Hulme W., Hedges D., Taylor C.M., Flemington E.K.
Whole-genome sequencing of the Akata and Mutu Epstein-Barr virus strains.
J. Virol. 87:1172-1182(2013)

PubMed=25787276; DOI=10.1128/JVI.03614-14
Palser A.L., Grayson N.E., White R.E., Corton C., Correia S., Ba Abdullah M.M., Watson S.J., Cotten M., Arrand J.R., Murray P.G., Allday M.J., Rickinson A.B., Young L.S., Farrell P.J., Kellam P.
Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection.
J. Virol. 89:5222-5237(2015)

PubMed=28960205; DOI=10.1038/cdd.2017.150
Fitzsimmons L., Boyce A.J., Wei W.-B., Chang C., Croom-Carter D.S.G., Tierney R.J., Herold M.J., Bell A.I., Strasser A., Kelly G.L., Rowe M.
Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells.
Cell Death Differ. 25:241-254(2018)