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Cellosaurus Akata (CVCL_0148)

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Cell line name Akata
Synonyms AKATA; Akata-BL; Akata BL; Akata-EC; Akata-Early Culture
Accession CVCL_0148
Resource Identification Initiative To cite this cell line use: Akata (RRID:CVCL_0148)
Comments Population: Japanese.
Characteristics: Contains a complete EBV genome (strain Akata) which has been sequenced (PubMed=23152513; PubMed=25787276).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Sequence variations Mutation; HGNC; 11998; TP53; Simple; p.Pro190Leufs*57 (c.569delC); Zygosity=Unspecified (PubMed=1915267).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_6247 (Akata 2A8)CVCL_6248 (Akata 2C1)CVCL_6249 (Akata 3F2)
CVCL_6250 (Akata EG)CVCL_VN89 (Akata-EBV-N)CVCL_VN87 (Akata-EBV-P)
CVCL_VN88 (Akata-eGFP-EBV)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
STR profile Source(s): JCRB

Markers:
AmelogeninX
CSF1PO11
D5S81811,12
D7S82010,12
D13S3178,12
D16S53910,11
TH019
TPOX8,11
vWA14,16

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Publications

PubMed=1647567; DOI=10.1007/BF00571929
Takada K., Horinouchi K., Ono Y., Aya T., Osato T., Takahashi M., Hayasaka S.
An Epstein-Barr virus-producer line Akata: establishment of the cell line and analysis of viral DNA.
Virus Genes 5:147-156(1991)

PubMed=1915267; DOI=10.1002/j.1460-2075.1991.tb07837.x
Farrell P.J., Allan G.J., Shanahan F., Vousden K.H., Crook T.
p53 is frequently mutated in Burkitt's lymphoma cell lines.
EMBO J. 10:2879-2887(1991)

PubMed=9473234; DOI=10.1182/blood.V91.5.1680
Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Blood 91:1680-1687(1998)

PubMed=9973220
Gutierrez M.I., Cherney B.W., Hussain A., Mostowski H.S., Tosato G., Magrath I.T., Bhatia K.G.
Bax is frequently compromised in Burkitt's lymphomas with irreversible resistance to Fas-induced apoptosis.
Cancer Res. 59:696-703(1999)

PubMed=11559830; DOI=10.1128/JVI.75.20.9977-9982.2001
Maruo S., Nanbo A., Takada K.
Replacement of the Epstein-Barr virus plasmid with the EBER plasmid in Burkitt's lymphoma cells.
J. Virol. 75:9977-9982(2001)

PubMed=23152513; DOI=10.1128/JVI.02517-12
Lin Z., Wang X., Strong M.J., Concha M., Baddoo M., Xu G., Baribault C., Fewell C., Hulme W., Hedges D., Taylor C.M., Flemington E.K.
Whole-genome sequencing of the Akata and Mutu Epstein-Barr virus strains.
J. Virol. 87:1172-1182(2013)

PubMed=25787276; DOI=10.1128/JVI.03614-14
Palser A.L., Grayson N.E., White R.E., Corton C., Correia S., Ba Abdullah M.M., Watson S.J., Cotten M., Arrand J.R., Murray P.G., Allday M.J., Rickinson A.B., Young L.S., Farrell P.J., Kellam P.
Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection.
J. Virol. 89:5222-5237(2015)

PubMed=28960205; DOI=10.1038/cdd.2017.150
Fitzsimmons L., Boyce A.J., Wei W., Chang C., Croom-Carter D.S.G., Tierney R.J., Herold M.J., Bell A.I., Strasser A., Kelly G.L., Rowe M.
Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells.
Cell Death Differ. 25:241-254(2018)

Cross-references
Cell line collections JCRB; JCRB1763
NCBI_Iran; C451
Cell line databases/resources TOKU-E; 3580
Ontologies MCCL; MCC:0000041
Other Wikidata; Q54749080
Polymorphism and mutation databases Cosmic; 931094
Cosmic; 2301567
IARC_TP53; 698
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number17