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Cellosaurus Akata (CVCL_0148)

[Text version]

Cell line name Akata
Synonyms AKATA; Akata-BL; Akata BL; Akata-EC; Akata-Early Culture
Accession CVCL_0148
Resource Identification Initiative To cite this cell line use: Akata (RRID:CVCL_0148)
Comments Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Sequence variations TP53 p.Pro190Leufs*57 (c.569delC) (PubMed=1915267).
Disease Epstein-Barr virus-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_6247 (Akata 2A8)CVCL_6248 (Akata 2C1)CVCL_6249 (Akata 3F2)
CVCL_6250 (Akata EG)CVCL_VN89 (Akata-EBV-N)CVCL_VN87 (Akata-EBV-P)
CVCL_VN88 (Akata-eGFP-EBV)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
STR profile Source(s): JCRB

Markers:
AmelogeninX
CSF1PO11
D5S81811,12
D7S82010,12
D13S3178,12
D16S53910,11
TH019
TPOX8,11
vWA14,16

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Publications

PubMed=1647567; DOI=10.1007/BF00571929
Takada K., Horinouchi K., Ono Y., Aya T., Osato T., Takahashi M., Hayasaka S.
An Epstein-Barr virus-producer line Akata: establishment of the cell line and analysis of viral DNA.
Virus Genes 5:147-156(1991)

PubMed=1915267; DOI=10.1002/j.1460-2075.1991.tb07837.x
Farrell P.J., Allan G.J., Shanahan F., Vousden K.H., Crook T.
p53 is frequently mutated in Burkitt's lymphoma cell lines.
EMBO J. 10:2879-2887(1991)

PubMed=9473234; DOI=10.1182/blood.V91.5.1680
Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Blood 91:1680-1687(1998)

PubMed=9973220
Gutierrez M.I., Cherney B., Hussain A., Mostowski H., Tosato G., Magrath I.T., Bhatia K.
Bax is frequently compromised in Burkitt's lymphomas with irreversible resistance to Fas-induced apoptosis.
Cancer Res. 59:696-703(1999)

PubMed=11559830; DOI=10.1128/JVI.75.20.9977-9982.2001
Maruo S., Nanbo A., Takada K.
Replacement of the Epstein-Barr virus plasmid with the EBER plasmid in Burkitt's lymphoma cells.
J. Virol. 75:9977-9982(2001)

Cross-references
Cell line collections JCRB; JCRB1763
NCBI_Iran; C451
Cell line databases/resources TOKU-E; 3580
Ontologies MCCL; MCC:0000041
Other Wikidata; Q54749080
Polymorphism and mutation databases Cosmic; 931094
Cosmic; 2301567
IARC_TP53; 698
Entry history
Entry creation04-Apr-2012
Last entry updated12-Mar-2020
Version number15