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Cellosaurus BCBL-1 (CVCL_0165)

[Text version]

Cell line name BCBL-1
Synonyms BCBL1; BCBL
Accession CVCL_0165
Resource Identification Initiative To cite this cell line use: BCBL-1 (RRID:CVCL_0165)
Comments Part of: LL-100 blood cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Doubling time: ~50 hours (DSMZ).
Karyotypic information: Has lost chromosome Y.
Transformant: NCBI_TaxID; 37296; Human herpesvirus 8 (HHV-8/KSHV).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: H3K4me3 ChIP-seq epigenome analysis.
Omics: H3K27me3 ChIP-seq epigenome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis.
Derived from sampling site: Ascites.
Disease Primary effusion lymphoma (NCIt: C6915)
Primary effusion lymphoma (ORDO: Orphanet_48686)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
STR profile Source(s): DSMZ


Run an STR similarity search on this cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=BCBL-1

PubMed=8612236; DOI=10.1038/nm0396-342
Renne R., Zhong W., Herndier B.G., McGrath M.S., Abbey N.W., Kedes D., Ganem D.
Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture.
Nat. Med. 2:342-346(1996)

PubMed=9375005; DOI=10.1006/viro.1997.8822
Picchio G.R., Sabbe R.E., Gulizia R.J., McGrath M.S., Herndier B.G., Mosier D.E.
The KSHV/HHV8-infected BCBL-1 lymphoma line causes tumors in SCID mice but fails to transmit virus to a human peripheral blood mononuclear cell graft.
Virology 238:22-29(1997)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=15613351; DOI=10.1128/JVI.79.2.1244-1251.2005
Fan W., Bubman D., Chadburn A., Harrington W.J. Jr., Cesarman E., Knowles D.M.
Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association.
J. Virol. 79:1244-1251(2005)

PubMed=19521981; DOI=10.1002/ijc.24521
Takahashi-Makise N., Suzu S., Hiyoshi M., Ohsugi T., Katano H., Umezawa K., Okada S.
Biscoclaurine alkaloid cepharanthine inhibits the growth of primary effusion lymphoma in vitro and in vivo and induces apoptosis via suppression of the NF-kappaB pathway.
Int. J. Cancer 125:1464-1472(2009)

PubMed=21685375; DOI=10.1182/blood-2010-12-323659
Roy D., Sin S.-H., Damania B., Dittmer D.P.
Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.
Blood 118:E32-E39(2011)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cell line collections DSMZ; ACC-683
Cell line databases/resources Lonza; 238
TOKU-E; 4070
Ontologies BTO; BTO:0002727
EFO; EFO_0002048
MCCL; MCC:0000057
Biological sample resources BioSample; SAMN03473436
BioSamples; SAMEA365914
BioSamples; SAMEA365927
Gene expression databases ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM33134
GEO; GSM38800
GEO; GSM38801
GEO; GSM634735
GEO; GSM710421
GEO; GSM710437
GEO; GSM1265856
GEO; GSM1265857
GEO; GSM1265858
GEO; GSM1265859
GEO; GSM1265860
GEO; GSM1265868
Other Wikidata; Q54795334
Polymorphism and mutation databases Cosmic; 1238078
Cosmic; 1515185
Cosmic; 1588560
Entry history
Entry creation04-Apr-2012
Last entry update12-Mar-2020
Version number19