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Cellosaurus SK-N-BE(2)-M17 (CVCL_0167)

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Cell line name SK-N-BE(2)-M17
Synonyms BE(2)-M17; BE(2)M17; BE(2)M-17; BE2-M17; BE2M17
Accession CVCL_0167
Resource Identification Initiative To cite this cell line use: SK-N-BE(2)-M17 (RRID:CVCL_0167)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK1980-531.
Characteristics: Neuroblastic type (N-type) (PubMed=15720811).
Doubling time: 20-24 hours (ECACC).
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Sequence variations Gene deletion; HGNC; 11998; TP53; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Cys135Phe (c.404G>T); ClinVar=VCV000376559; Zygosity=Heterozygous (Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American1.22
East Asian, North3.24
East Asian, South0
South Asian6.24
European, North21.38
European, South64
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0528 (SK-N-BE(2))
Sex of cell Male
Age at sampling 2Y2M
Category Cancer cell line
STR profile Source(s): ATCC; CCRID; Cosmic-CLP; ECACC; JCRB; PubMed=25877200

D2S133817,23 (PubMed=25877200)
23 (CCRID)
D16S5399,11 (CCRID)
11 (ATCC; Cosmic-CLP; ECACC; JCRB; PubMed=25877200)
D18S5114 (PubMed=25877200)
16,26 (CCRID)
Penta D13,14
Penta E14,18
TPOX8,11 (ATCC; Cosmic-CLP; ECACC; JCRB; PubMed=25877200)
11 (CCRID)
vWA17,18 (Cosmic-CLP; JCRB)
18 (ATCC; CCRID; ECACC; PubMed=25877200)

Run an STR similarity search on this cell line
Web pages https://www.mskcc.org/research-advantage/support/technology/tangible-material/sk-n-be-2-m17-human-neuroblastoma-cell-line

Ciccarone V., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A.
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.
Cancer Res. 49:219-225(1989)

Glick R.D., Swendeman S.L., Coffey D.C., Rifkind R.A., Marks P.A., Richon V.M., La Quaglia M.P.
Hybrid polar histone deacetylase inhibitor induces apoptosis and CD95/CD95 ligand expression in human neuroblastoma.
Cancer Res. 59:4392-4399(1999)

PubMed=15720811; DOI=10.1593/neo.04310
Walton J.D., Kattan D.R., Thomas S.K., Spengler B.A., Guo H.-F., Biedler J.L., Cheung N.-K.V., Ross R.A.
Characteristics of stem cells from human neuroblastoma cell lines and in tumors.
Neoplasia 6:838-845(2004)

PubMed=15892104; DOI=10.1002/gcc.20198
Mosse Y.P., Greshock J., Margolin A.A., Naylor T., Cole K., Khazi D., Hii G., Winter C., Shahzad S., Asziz M.U., Biegel J.A., Weber B.L., Maris J.M.
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=26342562; DOI=10.1016/j.scr.2015.08.008
Ross R.A., Walton J.D., Han D., Guo H.-F., Cheung N.-K.V.
A distinct gene expression signature characterizes human neuroblastoma cancer stem cells.
Stem Cell Res. 15:419-426(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections ATCC; CRL-2267
ECACC; 95011816
JCRB; JCRB9131 - Discontinued
JCRB; NIHS0221 - Discontinued
NCBI_Iran; C614
Cell line databases/resources CLDB; cl407
CCRID; 1101HUM-PUMC000076
Cell_Model_Passport; SIDM01229
Cosmic-CLP; 753616
DepMap; ACH-002217
Lonza; 1236
Ontologies BTO; BTO:0002104
CLO; CLO_0001916
MCCL; MCC:0000059
Biological sample resources BioSample; SAMN03471024
BioSample; SAMN03472366
Chemistry resources GDSC; 753616
PharmacoDB; BE2M17_85_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669614
Other Wikidata; Q54954446
Polymorphism and mutation databases Cosmic; 753616
Cosmic; 1167416
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number28