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Cellosaurus SK-N-BE(2)-M17 (CVCL_0167)

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Cell line name SK-N-BE(2)-M17
Synonyms BE(2)-M17; BE(2)M17; BE(2)M-17; BE2-M17; BE2M17
Accession CVCL_0167
Resource Identification Initiative To cite this cell line use: SK-N-BE(2)-M17 (RRID:CVCL_0167)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK1980-531.
Characteristics: Neuroblastic type (N-type) (PubMed=15720811).
Doubling time: 20-24 hours (ECACC).
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for TP53 p.Cys135Phe (c.404G>T) (Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.92
Native American1.22
East Asian, North3.24
East Asian, South0
South Asian6.24
European, North21.38
European, South64
Disease Neuroblastoma (NCIt: C3270)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0528 (SK-N-BE(2))
Sex of cell Male
Age at sampling 1Y10M
Category Cancer cell line
STR profile Source(s): ATCC; CCRID; Cosmic-CLP; ECACC; JCRB; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10
D2S133823 (CCRID)
17,23 (PubMed=25877200)
D3S135819
D5S81812
D7S8209,10
D8S117913,14
D13S31711
D16S53911 (ATCC; Cosmic-CLP; ECACC; JCRB; PubMed=25877200)
9,11 (CCRID)
D18S5116,26 (CCRID)
14 (PubMed=25877200)
D19S43312,13
D21S1130,32.2
FGA22,25
Penta D13,14
Penta E14,18
TH016
TPOX8,11 (ATCC; Cosmic-CLP; ECACC; JCRB; PubMed=25877200)
11 (CCRID)
vWA18 (ATCC; CCRID; ECACC; PubMed=25877200)
17,18 (Cosmic-CLP; JCRB)

Run an STR similarity search on this cell line
Web pages https://www.mskcc.org/research-advantage/support/technology/tangible-material/sk-n-be-2-m17-human-neuroblastoma-cell-line
http://www.cellresource.cn/fdetail.aspx?id=76
Publications

PubMed=2535691
Ciccarone V., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A.
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.
Cancer Res. 49:219-225(1989)

PubMed=10485488
Glick R.D., Swendeman S.L., Coffey D.C., Rifkind R.A., Marks P.A., Richon V.M., La Quaglia M.P.
Hybrid polar histone deacetylase inhibitor induces apoptosis and CD95/CD95 ligand expression in human neuroblastoma.
Cancer Res. 59:4392-4399(1999)

PubMed=15720811; DOI=10.1593/neo.04310
Walton J.D., Kattan D.R., Thomas S.K., Spengler B.A., Guo H.-F., Biedler J.L., Cheung N.-K.V., Ross R.A.
Characteristics of stem cells from human neuroblastoma cell lines and in tumors.
Neoplasia 6:838-845(2004)

PubMed=26342562; DOI=10.1016/j.scr.2015.08.008
Ross R.A., Walton J.D., Han D., Guo H.-F., Cheung N.-K.V.
A distinct gene expression signature characterizes human neuroblastoma cancer stem cells.
Stem Cell Res. 15:419-426(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections ATCC; CRL-2267
ECACC; 95011816
JCRB; JCRB9131 - Discontinued
JCRB; NIHS0221 - Discontinued
NCBI_Iran; C614
Cell line databases/resources CLDB; cl407
CCLE; BE2M17_AUTONOMIC_GANGLIA
CCRID; 3111C0001CCC000076
Cell_Model_Passport; SIDM01229
Cosmic-CLP; 753616
DepMap; ACH-002217
GDSC; 753616
LINCS_LDP; LCL-1972
Lonza; 1236
Ontologies BTO; BTO:0002104
CLO; CLO_0001916
MCCL; MCC:0000059
Biological sample resources BioSample; SAMN03471024
BioSample; SAMN03472366
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669614
Other Wikidata; Q54954446
Polymorphism and mutation databases Cosmic; 753616
Cosmic; 1167416
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number22