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Cellosaurus BEAS-2B (CVCL_0168)

Cell line name BEAS-2B
Synonyms Beas-2B; BEAS 2B; BEAS2B; Beas2B; Bronchial Epithelium transformed with Ad12-SV40 2B
Accession CVCL_0168
Resource Identification Initiative To cite this cell line use: BEAS-2B (RRID:CVCL_0168)
Comments Part of: Small cell lung cancer p53 hotspot mutation cell panel (ATCC TCP-2040).
Transformant: Ad12-SV40.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4400 (BBM)CVCL_LJ64 (BEAS-2B/c-myc)CVCL_LJ65 (BEAS-2B/c-raf-1)
CVCL_LJ66 (BEAS-2B/c-raf-1/c-myc)CVCL_LJ61 (BEAS-2B/EJ-ras)CVCL_LJ62 (BEAS-2B/N-ras)
CVCL_LJ63 (BEAS-2B/S6)CVCL_LJ68 (BERB)CVCL_LJ71 (Bp53MT143)
CVCL_LJ70 (Bp53WT)CVCL_LJ60 (BVK-Tll)CVCL_3658 (BZR)
Originate from same individual CVCL_0171 ! BET-1A
Sex of cell Male
Category Transformed cell line
STR profile Source(s): ATCC; ECACC; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO9,12
D13S31713
D16S53912 (ATCC; ECACC)
11,12 (PubMed=25877200)
D18S5118,19
D19S43313.2
D21S1128,30
D2S133822,23
D3S135815,17
D5S81812,13
D7S82010,13
D8S117913,15
FGA20,24
Penta D2.2,13
Penta E5,8
TH017,9.3
TPOX6,11
vWA17,18
Web pages http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/b/cell-lines-detail-39.html
Publications

PubMed=2450641
Reddel R.R., Ke Y., Gerwin B.I., McMenamin M.G., Lechner J.F., Su R.T., Brash D.E., Park J.-B., Rhim J.S., Harris C.C.
Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes.
Cancer Res. 48:1904-1909(1988)

Patent=US4885238
Reddel R.R., Yang K., Rhim J.S., Brash D.E., Su R.T., Lechner J.F., Gerwin B.I., Harris C.C., Amstad P.
Immortalized human bronchial epithelial mesothelial cell lines.
Patent number US4885238, 05-Dec-1989

PubMed=2539488; DOI=10.1093/jnci/81.8.587
Bonfil R.D., Reddel R.R., Ura H., Reich R., Fridman R., Harris C.C., Klein-Szanto A.J.P.
Invasive and metastatic potential of a v-Ha-ras-transformed human bronchial epithelial cell line.
J. Natl. Cancer Inst. 81:587-594(1989)

DOI=10.1007/978-1-4612-0411-4_25
Lehman T.A., Harris C.C.
Neoplastic transformation and suppression of transformation of human bronchial epithelial cells in vitro.
(In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.251-258; Humana Press; New York (1990)

PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040
Gruenert D.C., Willems M., Cassiman J.J., Frizzell R.A.
Established cell lines used in cystic fibrosis research.
J. Cyst. Fibros. 3:191-196(2004)

PubMed=17331233; DOI=10.1186/1471-2164-8-62
Nymark P., Lindholm P.M., Korpela M.V., Lahti L., Ruosaari S., Kaski S., Hollmen J., Anttila S., Kinnula V.L., Knuutila S.
Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines.
BMC Genomics 8:62-62(2007)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22521957; DOI=10.1016/j.taap.2012.04.003
Stueckle T.A., Lu Y., Davis M.E., Wang L., Jiang B.-H., Holaskova I., Schafer R., Barnett J.B., Rojanasakul Y.
Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells.
Toxicol. Appl. Pharmacol. 261:204-216(2012)

PubMed=25524072; DOI=10.1002/jat.3094
Zhao F., Klimecki W.T.
Culture conditions profoundly impact phenotype in BEAS-2B, a human pulmonary epithelial model.
J. Appl. Toxicol. 35:945-951(2015)

Cross-references
Cell line collections AddexBio; T0007001/26
ATCC; CRL-9609
BCRJ; 0395
ECACC; 95102433
KCB; KCB 200922YJ
NCBI_Iran; C561
Cell line databases/resources CCRID; 3131C0001000200027
CCRID; 3153C0001000000175
Lonza; 343
Ontologies BTO; BTO:0002923
CLO; CLO_0001925
EFO; EFO_0001089
MCCL; MCC:0000060
Biological sample resources BioSample; SAMN03471073
BioSample; SAMN03472862
Gene expression databases GEO; GSE33520
GEO; GSM139654
GEO; GSM139655
GEO; GSM139656
GEO; GSM139657
GEO; GSM139659
GEO; GSM139660
GEO; GSM139661
GEO; GSM139663
GEO; GSM139664
GEO; GSM139666
GEO; GSM253389
GEO; GSM827258
Other Wikidata; Q54795940
Proteomic databases PRIDE; PXD003503