ID   bEnd.3
AC   CVCL_0170
SY   bEND.3; b.End3; Bend.3; bEnd3; BEND3; brain-derived Endothelial cells.3
DR   BTO; BTO:0003353
DR   CLO; CLO_0001777
DR   CLO; CLO_0001928
DR   MCCL; MCC:0000496
DR   CLDB; cl5049
DR   AddexBio; C0005030/5019
DR   ATCC; CRL-2299
DR   BCRC; 60515
DR   ECACC; 96091929
DR   JCRB; NIHS0319
DR   CCRID; 3101MOUTCM40
DR   Wikidata; Q52183429
RX   PubMed=2379237;
RX   PubMed=14568334;
RX   PubMed=22224974;
RX   PubMed=25282873;
WW   https://en.wikipedia.org/wiki/BEnd.3
WW   https://www.atcc.org/en/support/technical-support/faqs/morphology-of-atcc-crl-2299
CC   Characteristics: Widely used for blood vascular research.
CC   Doubling time: 26-30 hours (PubMed=14568334).
CC   Transformant: Polyoma middle T antigen (PyMLV).
CC   Discontinued: JCRB; NIHS0319; true.
CC   Breed/subspecies: BALB/c.
OX   NCBI_TaxID=10090; ! Mus musculus
SX   Sex unspecified
AG   6W
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 23-09-21; Version: 13
//
RX   PubMed=2379237; DOI=10.1016/0092-8674(90)90009-4;
RA   Montesano R., Pepper M.S., Mohle-Steinlein U., Risau W., Wagner E.F.,
RA   Orci L.;
RT   "Increased proteolytic activity is responsible for the aberrant
RT   morphogenetic behavior of endothelial cells expressing the middle T
RT   oncogene.";
RL   Cell 62:435-445(1990).
//
RX   PubMed=14568334; DOI=10.1016/S0006-8993(03)03443-7;
RA   Omidi Y., Campbell L., Barar J., Connell D., Akhtar S., Gumbleton M.;
RT   "Evaluation of the immortalised mouse brain capillary endothelial cell
RT   line, b.End3, as an in vitro blood-brain barrier model for drug uptake
RT   and transport studies.";
RL   Brain Res. 990:95-112(2003).
//
RX   PubMed=22224974; DOI=10.1089/scd.2011.0501;
RA   Joubin K., Richardson A., Novoa N., Tu E., Tomishima M.J.;
RT   "The endothelial cell line bEnd.3 maintains human pluripotent stem
RT   cells.";
RL   Stem Cells Dev. 21:2312-2321(2012).
//
RX   PubMed=25282873;
RA   Yuen D., Leu R., Tse J., Wang S., Chen L.L., Chen L.;
RT   "Novel characterization of bEnd.3 cells that express lymphatic vessel
RT   endothelial hyaluronan receptor-1.";
RL   Lymphology 47:73-81(2014).
//