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Cellosaurus BV-2 (CVCL_0182)

[Text version]
Cell line name BV-2
Synonyms BV2
Accession CVCL_0182
Resource Identification Initiative To cite this cell line use: BV-2 (RRID:CVCL_0182)
Comments Transformant: Recombinant retrovirus J2.
Omics: Secretome proteome analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Cell type: Microglial cell; CL=CL_0000129.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Children:
CVCL_ZJ35 (BV-2 PU.1 KO)CVCL_XD67 (BV2-EGFP)CVCL_C8UX (BV2-Luc)
CVCL_WJ28 (BV2-mCherry)CVCL_XD66 (BV2-tDT)
Sex of cell Female
Age at sampling 1W
Category Transformed cell line
STR profile Source(s): Ubigene

Markers:
Mouse STR 4-220.3
Mouse STR 5-517
Mouse STR 6-417.3
Mouse STR 6-715
Mouse STR 12-116
Mouse STR 15-322.3,23.3,24.3
Mouse STR 18-316,17
Mouse STR X-127

Run an STR similarity search on this cell line
Publications

PubMed=2110186; DOI=10.1016/0165-5728(90)90073-V
Blasi E., Barluzzi R., Bocchini V., Mazzolla R., Bistoni F.
Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus.
J. Neuroimmunol. 27:229-237(1990)

PubMed=19565166; DOI=10.14573/altex.2009.2.83
Henn A., Lund S., Hedtjarn M., Schrattenholz A., Porzgen P., Leist M.
The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation.
ALTEX 26:83-94(2009)

PubMed=21961028; DOI=10.2174/1877381801002010148
Crain J.M., Watters J.J.
Estrogen and P2 purinergic receptor systems in microglia: therapeutic targets for neuroprotection.
Open Drug Discov. J. 2:148-167(2010)

PubMed=21214938; DOI=10.1186/1471-2164-12-14
Atwood B.K., Lopez J., Wager-Miller J., Mackie K., Straiker A.
Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis.
BMC Genomics 12:14.1-14.14(2011)

PubMed=22651808; DOI=10.1186/1742-2094-9-115
Stansley B., Post J., Hensley K.
A comparative review of cell culture systems for the study of microglial biology in Alzheimer's disease.
J. Neuroinflamm. 9:115.1-115.8(2012)

PubMed=26227174; DOI=10.1002/pmic.201400623
Woo J.-M., Han D.-H., Park J.-H., Kim S.-J., Kim Y.-S.
In-depth characterization of the secretome of mouse CNS cell lines by LC-MS/MS without prefractionation.
Proteomics 15:3617-3622(2015)

DOI=10.1007/s13273-019-00057-6
Mandal C., Yoon T., Park J.Y., Jung K.H., Chai Y.G.
Lipopolysaccharide-dependent transcriptional regulation of PU.1 in microglial cells.
Mol. Cell. Toxicol. 16:51-61(2020)

Cross-references
Cell line collections (Providers) BCRJ; 0356
CCTCC; GDC0311
CLS; 305156
ICLC; ATL03001
KCB; KCB 200770YJ
Ubigene; YC-C035
Cell line databases/resources MCCL; MCC:0000073
CLDB; cl7130
CCRID; 1101MOU-PUMC000063
CCRID; 4201MOU-CCTCC00311
Lonza; 118
Anatomy/cell type resources BTO; BTO:0003350
CRISP screens repositories BioGRID_ORCS_Cell_line; 765
Chemistry resources ChEMBL-Cells; CHEMBL3307704
ChEMBL-Targets; CHEMBL614781
PubChem_Cell_line; CVCL_0182
Encyclopedic resources Wikidata; Q54798657
Gene expression databases GEO; GSM635468
GEO; GSM635469
GEO; GSM635470
GEO; GSM635471
Proteomic databases PRIDE; PXD001597
PRIDE; PXD004984
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number25