ID   C6
AC   CVCL_0194
AS   CVCL_4060
SY   C-6; C 6; RGC-6; RGC6; RGc6
DR   BTO; BTO:0000529
DR   CLO; CLO_0002072
DR   CLO; CLO_0002140
DR   CLO; CLO_0051387
DR   CLO; CLO_0051388
DR   MCCL; MCC:0000085
DR   CLDB; cl579
DR   CLDB; cl580
DR   CLDB; cl581
DR   CLDB; cl583
DR   CLDB; cl5165
DR   ATCC; CCL-107
DR   BCRC; 60046
DR   BCRJ; 0057
DR   CCRID; 1101RAT-PUMC000131
DR   CCRID; 1102RAT-NIFDC00048
DR   CCRID; 3101RATTCR1
DR   ChEMBL-Cells; CHEMBL3308345
DR   ChEMBL-Targets; CHEMBL614657
DR   CLS; 500142
DR   DSMZ; ACC-550
DR   DSMZCellDive; ACC-550
DR   ECACC; 92090409
DR   ICLC; ATL95007
DR   IZSLER; BS TCL 5
DR   JCRB; IFO50110
DR   JCRB; JCRB9096
DR   KCB; KCB 93026YJ
DR   KCLB; 10107
DR   Lonza; 27
DR   NCBI_Iran; C575
DR   PRIDE; PXD026776
DR   PubChem_Cell_line; CVCL_0194
DR   RCB; RCB2783
DR   RCB; RCB2854
DR   TKG; TKG 0242
DR   TKG; TKG 0589
DR   TOKU-E; 750
DR   Wikidata; Q54808212
RX   CelloPub=CLPUB00233;
RX   DOI=10.1007/BF02618370;
RX   DOI=10.5005/jp-journals-10082-02230;
RX   PubMed=2303323;
RX   PubMed=2303324;
RX   PubMed=3468959;
RX   PubMed=4873531;
RX   PubMed=19381449;
RX   PubMed=25492533;
RX   PubMed=34917708;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-129.html
CC   Doubling time: 14.75 hours (PubMed=2303324); 24-28 hours (DOI=10.5005/jp-journals-10082-02230); ~24 hours (CLS=500142); ~25-30 hours (DSMZ=ACC-550).
CC   Transformant: ChEBI; CHEBI:50102; N-methyl-N-nitrosourea (NMU).
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: Mitochondrial genome sequenced.
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
CC   Breed/subspecies: Wistar Furth.
DI   NCIt; C64069; Rat malignant glioma
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 31
//
RX   CelloPub=CLPUB00233;
RA   Lightbody J.;
RT   "Establishment of differentiated clonal strains of glial brain cells
RT   in culture.";
RL   Fed. Proc. 27:720-720(1968).
//
RX   DOI=10.1007/BF02618370;
RA   Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.;
RT   "The animal cell culture collection.";
RL   In Vitro 5:1-16(1970).
//
RX   DOI=10.5005/jp-journals-10082-02230;
RA   Kuduvalli S.S., Ramalakshmi O., Precilla S.D., Anitha T.S.;
RT   "Evaluation of cell doubling time in C6 and Y79 cell lines based on
RT   seeding density.";
RL   SBV J. Basic Clin. Appl. Heatlh Sci. 2:146-149(2019).
//
RX   PubMed=2303323;
RA   Brauner T., Schmid A., Hulser D.F.;
RT   "Tumor cell invasion and gap junctional communication. I. Normal and
RT   malignant cells confronted in monolayer cultures.";
RL   Invasion Metastasis 10:18-30(1990).
//
RX   PubMed=2303324;
RA   Brauner T., Hulser D.F.;
RT   "Tumor cell invasion and gap junctional communication. II. Normal and
RT   malignant cells confronted in multicell spheroids.";
RL   Invasion Metastasis 10:31-48(1990).
//
RX   PubMed=3468959;
RA   Yoshida T., Shimizu K., Ushio Y., Mogami H., Sakamoto Y.;
RT   "Possibility of overcoming of ACNU resistance in an ACNU-resistant
RT   subline of C6 rat glioma.";
RL   No To Shinkei 38:1065-1070(1986).
//
RX   PubMed=4873531; DOI=10.1126/science.161.3839.370;
RA   Benda P., Lightbody J., Sato G.H., Levine L., Sweet W.H.;
RT   "Differentiated rat glial cell strain in tissue culture.";
RL   Science 161:370-371(1968).
//
RX   PubMed=19381449; DOI=10.1007/s11060-009-9875-7;
RA   Barth R.F., Kaur B.;
RT   "Rat brain tumor models in experimental neuro-oncology: the C6, 9L,
RT   T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomas.";
RL   J. Neurooncol. 94:299-312(2009).
//
RX   PubMed=25492533; DOI=10.3109/19401736.2014.982619;
RA   Gao J., Hu L., Peng H.-H., Shi J.-G.;
RT   "The complete mitochondrial genome sequence of the rat C6 glioma cell
RT   line.";
RL   Mitochondrial DNA 27:2188-2189(2016).
//
RX   PubMed=34917708; DOI=10.1016/j.dib.2021.107658;
RA   Silantyev A.S., Bukato O.N., Butenko I.O., Chernysheva A.A.,
RA   Pobeguts O.V., Nosyrev A.E., Gurina O.I.;
RT   "Proteomic dataset: profiling of glioma C6 and astrocytes rat cell
RT   lines before and after co-cultivation.";
RL   Data Brief 39:107658.1-107658.9(2021).
//