ID   Caov-3
AC   CVCL_0201
AS   CVCL_0231
SY   CaOv-3; CaOV-3; CAOV-3; CAOV3; CaOV3; CaOv3; Caov3; CA-OV-3
DR   BTO; BTO:0000814
DR   CLO; CLO_0002195
DR   EFO; EFO_0002148
DR   MCCL; MCC:0000119
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ATCC; HTB-75
DR   BioSample; SAMN03472624
DR   BioSample; SAMN05292465
DR   CCLE; CAOV3_OVARY
DR   CCRID; 3111C0001CCC000339
DR   CCRID; 3142C0001000000121
DR   Cell_Model_Passport; SIDM00919
DR   ChEMBL-Cells; CHEMBL3307927
DR   ChEMBL-Targets; CHEMBL614379
DR   Cosmic; 687927
DR   Cosmic; 688092
DR   Cosmic; 809114
DR   Cosmic; 844349
DR   Cosmic; 906579
DR   Cosmic; 906825
DR   Cosmic; 924149
DR   Cosmic; 949225
DR   Cosmic; 1102821
DR   Cosmic; 1139227
DR   Cosmic; 1305310
DR   Cosmic; 1312190
DR   Cosmic; 1707569
DR   Cosmic; 1709259
DR   Cosmic; 2186585
DR   Cosmic; 2301585
DR   Cosmic-CLP; 906825
DR   GDSC; 906825
DR   GEO; GSM184398
DR   GEO; GSM184399
DR   GEO; GSM274705
DR   GEO; GSM313711
DR   GEO; GSM459740
DR   GEO; GSM659371
DR   GEO; GSM784569
DR   GEO; GSM851913
DR   GEO; GSM886918
DR   GEO; GSM887984
DR   GEO; GSM1001485
DR   GEO; GSM1291130
DR   GEO; GSM1669661
DR   IARC_TP53; 1416
DR   IGRhCellID; CaOv3
DR   IZSLER; BS TCL 165
DR   KCB; KCB 2013041YJ
DR   LINCS_LDP; LCL-1519
DR   Wikidata; Q54808585
RX   PubMed=3518877;
RX   PubMed=4016745;
RX   PubMed=9698466;
RX   PubMed=12080474;
RX   PubMed=18560578;
RX   PubMed=20215515;
RX   PubMed=22328975;
RX   PubMed=22460905;
RX   PubMed=22710073;
RX   PubMed=23415752;
RX   PubMed=23839242;
RX   PubMed=24023729;
RX   PubMed=25230021;
RX   PubMed=25485619;
RX   PubMed=25984343;
RX   PubMed=27235858;
RX   PubMed=27397505;
RX   PubMed=27561551;
RX   PubMed=28196595;
RX   PubMed=30485824;
WW   https://physics.cancer.gov/docs/bioresource/ovary/NCI-PBCF-HTB75_Caov-3_SOP-508.pdf
WW   https://www.mskcc.org/research-advantage/support/technology/tangible-material/caov-3-human-ovarian-cell-line
WW   http://tcpaportal.org/mclp/
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: OCCP ovarian cancer cell line panel.
CC   From: Memorial Sloan Kettering Cancer Center; New York; USA.
CC   Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK2010-069.
CC   Doubling time: 78 hours (PubMed=4016745); 68 hours (PubMed=25984343); ~44 hours (PBCF).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Homozygous for TP53 p.Gln136Ter (c.406C>T) (ATCC; PubMed=24023729; PubMed=25230021).
CC   Omics: Deep exome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Genome sequenced.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Secretome proteome analysis.
CC   Omics: shRNA library screening.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Misspelling: CACOV-3; Occasionally.
CC   Misspelling: CaCOV3; Occasionally.
CC   Misspelling: CAVO3; Occasionally.
ST   Source(s): ATCC; Cosmic-CLP; PubMed=25230021; PubMed=25877200; PubMed=30485824
ST   Amelogenin: X
ST   CSF1PO: 10,13
ST   D13S317: 12
ST   D16S539: 9
ST   D18S51: 18
ST   D19S433: 14,17
ST   D21S11: 30
ST   D2S1338: 16,17
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 10
ST   D8S1179: 9,14
ST   FGA: 24
ST   Penta D: 12
ST   Penta E: 11,15
ST   TH01: 7
ST   TPOX: 8,10
ST   vWA: 16,18
DI   NCIt; C105555; High grade ovarian serous adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Female
AG   54Y
CA   Cancer cell line
//
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//
RX   PubMed=4016745;
RA   Buick R.N., Pullano R., Trent J.M.;
RT   "Comparative properties of five human ovarian adenocarcinoma cell
RT   lines.";
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//
RX   PubMed=9698466; DOI=10.1006/gyno.1998.5039;
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RT   ovarian cancers.";
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RX   PubMed=12080474; DOI=10.1038/sj.onc.1205542;
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RT   "CL100 expression is down-regulated in advanced epithelial ovarian
RT   cancer and its re-expression decreases its malignant potential.";
RL   Oncogene 21:4435-4447(2002).
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RX   PubMed=18560578; DOI=10.1371/journal.pone.0002425;
RA   Faca V.M., Ventura A.P., Fitzgibbon M.P., Pereira-Faca S.R.,
RA   Pitteri S.J., Green A.E., Ireton R.C., Zhang Q., Wang H.,
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RT   "Proteomic analysis of ovarian cancer cells reveals dynamic processes
RT   of protein secretion and shedding of extra-cellular domains.";
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RT   "A genome-wide screen for microdeletions reveals disruption of
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RT   "Genomic complexity and AKT dependence in serous ovarian cancer.";
RL   Cancer Discov. 2:56-67(2012).
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RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
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RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017;
RA   Korch C., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K.,
RA   Lessey B.A., Jordan V.C., Bradford A.P.;
RT   "DNA profiling analysis of endometrial and ovarian cell lines reveals
RT   misidentification, redundancy and contamination.";
RL   Gynecol. Oncol. 127:241-248(2012).
//
RX   PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007;
RA   Stordal B., Timms K., Farrelly A., Gallagher D., Busschots S.,
RA   Renaud M., Thery J., Williams D., Potter J., Tran T., Korpanty G.,
RA   Cremona M., Carey M.S., Li J., Li Y., Aslan O., O'Leary J.J.,
RA   Mills G.B., Hennessy B.T.;
RT   "BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one
RT   functionally deleterious BRCA1 mutation.";
RL   Mol. Oncol. 7:567-579(2013).
//
RX   PubMed=23839242; DOI=10.1038/ncomms3126;
RA   Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.;
RT   "Evaluating cell lines as tumour models by comparison of genomic
RT   profiles.";
RL   Nat. Commun. 4:2126-2126(2013).
//
RX   PubMed=24023729; DOI=10.1371/journal.pone.0072162;
RA   Anglesio M.S., Wiegand K.C., Melnyk N., Chow C., Salamanca C.M.,
RA   Prentice L.M., Senz J., Yang W., Spillman M.A., Cochrane D.R.,
RA   Shumansky K., Shah S.P., Kalloger S.E., Huntsman D.G.;
RT   "Type-specific cell line models for type-specific ovarian cancer
RT   research.";
RL   PLoS ONE 8:E72162-E72162(2013).
//
RX   PubMed=25230021; DOI=10.1371/journal.pone.0103988;
RA   Beaufort C.M., Helmijr J.C.A., Piskorz A.M., Hoogstraat M.,
RA   Ruigrok-Ritstier K., Besselink N., Murtaza M., van IJcken W.F.J.,
RA   Heine A.A.J., Smid M., Koudijs M.J., Brenton J.D., Berns E.M.J.J.,
RA   Helleman J.;
RT   "Ovarian cancer cell line panel (OCCP): clinical importance of in
RT   vitro morphological subtypes.";
RL   PLoS ONE 9:E103988-E103988(2014).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H.,
RA   Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y.,
RA   Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D.,
RA   Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D.,
RA   Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S.,
RA   Zhang Z.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35;
RA   Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S.,
RA   East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H.,
RA   Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M.,
RA   Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S.,
RA   Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D.,
RA   Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C.,
RA   Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P.,
RA   Golub T.R., Root D.E., Hahn W.C.;
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035-140035(2014).
//
RX   PubMed=27235858; DOI=10.1016/j.ygyno.2016.05.028;
RA   Hernandez L., Kim M.K., Lyle L.T., Bunch K.P., House C.D., Ning F.,
RA   Noonan A.M., Annunziata C.M.;
RT   "Characterization of ovarian cancer cell lines as in vivo models for
RT   preclinical studies.";
RL   Gynecol. Oncol. 142:332-340(2016).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M.,
RA   Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M.,
RA   Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A.,
RA   Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=27561551; DOI=10.1038/ncomms12645;
RA   Coscia F., Watters K.M., Curtis M., Eckert M.A., Chiang C.Y.,
RA   Tyanova S., Montag A., Lastra R.R., Lengyel E., Mann M.;
RT   "Integrative proteomic profiling of ovarian cancer cell lines reveals
RT   precursor cell associated proteins and functional status.";
RL   Nat. Commun. 7:12645-12645(2016).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P.,
RA   Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=30485824; DOI=10.1016/j.celrep.2018.10.096;
RA   Papp E., Hallberg D., Konecny G.E., Bruhm D.C., Adleff V., Noe M.,
RA   Kagiampakis I., Palsgrove D., Conklin D., Kinose Y., White J.R.,
RA   Press M.F., Drapkin R., Easwaran H., Baylin S.B., Slamon D.,
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RT   "Integrated genomic, epigenomic, and expression analyses of ovarian
RT   cancer cell lines.";
RL   Cell Rep. 25:2617-2633(2018).
//