Cell line name | CCRF-CEM | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Synonyms | CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Accession | CVCL_0207 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: CCRF-CEM (RRID:CVCL_0207) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Comments | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: LL-100 blood cancer cell line panel. Part of: MD Anderson Cell Lines Project. Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982). Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel. Part of: NCI-60 cancer cell line panel. Part of: NCI-7 clinical proteomics reference material cell line panel. Doubling time: 23 hours (PubMed=17117183); 24 hours (PubMed=20922763); 26.7 hours (NCI-DTP); ~24 hours (CLS); ~24-30 hours (DSMZ). Microsatellite instability: Instable (MSI-low) (PubMed=31068700; Sanger). Omics: Array-based CGH. Omics: CNV analysis. Omics: Deep exome analysis. Omics: Deep proteome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: Fluorescence phenotype profiling. Omics: Metabolome analysis. Omics: lncRNA expression profiling. Omics: Protein expression by reverse-phase protein arrays. Omics: Proteome analysis by 2D-DE/MS. Omics: SNP array analysis. Omics: Transcriptome analysis. Derived from sampling site: Peripheral blood. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sequence variations | Gene fusion; NKX2.5-BCL11B (PubMed=14500364).Heterozygous for FBXW7 p.Arg465Cys (c.1393C>T) (ClinVar=VCV000376414) (PubMed=11565033; CCLE; Cosmic-CLP).Heterozygous for FLT3 p.Ala627Thr (c.1879G>A) (PubMed=17088437; CCLE; Cosmic-CLP).Heterozygous for KRAS p.Gly12Asp (c.35G>A) (ClinVar=VCV000012582) (PubMed=17088437; CCLE; Cosmic-CLP).Heterozygous for NOTCH1 p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36) (PubMed=15472075).Heterozygous for NOTCH1 p.Pro2412Thr (c.7234C>A) (PubMed=15472075).Heterozygous for TP53 p.Arg175His (c.524G>A) (ClinVar=VCV000012374) (PubMed=2144611; PubMed=10071127; PubMed=17088437; CCLE; Cosmic-CLP).Heterozygous for TP53 p.Arg248Gln (c.743G>A) (ClinVar=VCV000012356) (PubMed=2144611; PubMed=10071127; PubMed=17088437; CCLE; Cosmic-CLP). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HLA typing | Source: PubMed=15748285
Source: IPD-IMGT/HLA; 10403
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Genome ancestry | Source: PubMed=30894373
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Disease | Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Hierarchy | Children:
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Sex of cell | Female | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Age at sampling | 3Y11M | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
STR profile | Source(s): AddexBio; ATCC; CLS; Cosmic-CLP; DSMZ; ECACC; JCRB; KCLB; PubMed=19372543; PubMed=20922763; RCB Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Web pages | https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm https://strap.nci.nih.gov/celline_detail.php?sample_id=29 http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-12.html http://www.cogcell.org/cellreqs-ncipptp.php http://www.pptpinvitro.org/cell_lines_panel.php http://www.nibsc.org/Default.aspx?pageid=597&id=0005&theme=default http://tcpaportal.org/mclp/ http://www.cellresource.cn/fdetail.aspx?id=697 http://www.cellresource.cn/fdetail.aspx?id=713 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Publications | PubMed=14278051; DOI=10.1002/1097-0142(196504)18:4<522::AID-CNCR2820180418>3.0.CO;2-J PubMed=5224274; DOI=10.1002/1097-0142(196611)19:11<1725::AID-CNCR2820191142>3.0.CO;2-T PubMed=6954533; DOI=10.1073/pnas.79.7.2194 PubMed=6198871; DOI=10.18926/AMO/32400 PubMed=6600440; DOI=10.1007/BF02617996 PubMed=6582512; DOI=10.1073/pnas.81.2.568 PubMed=3495441; DOI=10.1002/eji.1830170503 PubMed=3335022 PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x PubMed=2144611; DOI=10.1128/MCB.10.10.5502 PubMed=2255914; DOI=10.1126/science.2255914 PubMed=2041050; DOI=10.1093/jnci/83.11.757 CLPUB00447 PubMed=8127147 PubMed=7630190 PubMed=7888679; DOI=10.1182/blood.V85.6.1608.bloodjournal8561608 PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x PubMed=8641406; DOI=10.1111/j.1600-0609.1996.tb00721.x PubMed=9108419; DOI=10.1182/blood.V89.8.2986 PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x PubMed=9557624; DOI=10.1038/sj.leu.2400976 PubMed=9685479; DOI=10.1093/nar/26.16.3651 PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x PubMed=9787181; DOI=10.1182/blood.V92.9.3410 PubMed=9823951; DOI=10.1038/sj.leu.2401198 PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7 PubMed=10071127; DOI=10.1016/S0145-2126(98)00146-5 PubMed=10700174; DOI=10.1038/73432 DOI=10.1016/B978-0-12-221970-2.50457-5 PubMed=11565033; DOI=10.1038/35095068 PubMed=14500364 PubMed=15472075; DOI=10.1126/science.1102160 PubMed=15748285; DOI=10.1186/1479-5876-3-11 PubMed=31394625 PubMed=16408098; DOI=10.1038/sj.leu.2404081 PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433 PubMed=17117183; DOI=10.1038/sj.bjc.6603447 PubMed=17170727; DOI=10.1038/sj.leu.2404486 PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921 PubMed=20164919; DOI=10.1038/nature08768 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 PubMed=20922763; DOI=10.1002/pbc.22801 PubMed=22068913; DOI=10.1073/pnas.1111840108 PubMed=22384151; DOI=10.1371/journal.pone.0032096 PubMed=22675565; DOI=10.1371/journal.pone.0038463 PubMed=22628656; DOI=10.1126/science.1218595 PubMed=23856246; DOI=10.1158/0008-5472.CAN-12-3342 PubMed=23933261; DOI=10.1016/j.celrep.2013.07.018 PubMed=24279929; DOI=10.1186/2049-3002-1-20 PubMed=24670534; DOI=10.1371/journal.pone.0092047 PubMed=27377824; DOI=10.1038/sdata.2016.52 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 PubMed=27807467; DOI=10.1186/s13100-016-0078-4 PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005 PubMed=29718670; DOI=10.1021/acs.jproteome.8b00165 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 PubMed=31160637; DOI=10.1038/s41598-019-44491-x | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cell line collections | AddexBio; C0003001/32
ATCC; CCL-119 ATCC; CRM-CCL-119 ATCC; CRL-7916 - Discontinued ATCC; CRL-8436 BCRC; 60137 BCRJ; 0063 CCTCC; GDC0219 CLS; 300147/p752_CCRF-CEM Coriell; GM03671 DSMZ; ACC-240 ECACC; 85112105 IZSLER; BS TCL 11 JCRB; IFO50412 JCRB; JCRB0033 JCRB; JCRB9023 KCLB; 10119 NCBI_Iran; C105 NCI-DTP; CCRF-CEM RCB; RCB1980 TKG; TKG 0563 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLDB; cl675
CLDB; cl676 CLDB; cl677 CCLE; CCRFCEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCRID; 3131C0001000700129 CCRID; 3131C0001000700147 Cell_Model_Passport; SIDM00121 Cosmic-CLP; 905952 DepMap; ACH-001738 IGRhCellID; CCRFCEM IPD-IMGT/HLA; 10403 LINCS_LDP; LCL-1012 Lonza; 647 SKY/M-FISH/CGH; 2784 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ontologies | BTO; BTO:0000736
CLO; CLO_0002334 CLO; CLO_0015478 CLO; CLO_0050143 EFO; EFO_0002128 MCCL; MCC:0000096 MCCL; MCC:0000097 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN00808493
BioSample; SAMN01821675 BioSample; SAMN03471121 BioSample; SAMN03471203 BioSample; SAMN03472050 BioSample; SAMN03472700 BioSample; SAMN03472808 BioSample; SAMN03473385 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3307641
ChEMBL-Targets; CHEMBL382 ChEMBL-Targets; CHEMBL393 ChEMBL-Targets; CHEMBL614028 GDSC; 905952 PharmacoDB; CCRFCEM_190_2019 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783 ArrayExpress; E-MTAB-3610 ArrayExpress; E-MTAB-7721 ArrayExpress; E-MTAB-7722 GEO; GSM2116 GEO; GSM50193 GEO; GSM50257 GEO; GSM236780 GEO; GSM236816 GEO; GSM743457 GEO; GSM750806 GEO; GSM799345 GEO; GSM799408 GEO; GSM1153416 GEO; GSM1178011 GEO; GSM1178012 GEO; GSM1178013 GEO; GSM1181330 GEO; GSM1181347 GEO; GSM1374445 GEO; GSM1669670 GEO; GSM2124653 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Other | Wikidata; Q54809015 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 683716
Cosmic; 721708 Cosmic; 801728 Cosmic; 846384 Cosmic; 850198 Cosmic; 875863 Cosmic; 897449 Cosmic; 905952 Cosmic; 913411 Cosmic; 919157 Cosmic; 922674 Cosmic; 932765 Cosmic; 933544 Cosmic; 974251 Cosmic; 1012060 Cosmic; 1037690 Cosmic; 1044252 Cosmic; 1070703 Cosmic; 1071876 Cosmic; 1092595 Cosmic; 1115588 Cosmic; 1118462 Cosmic; 1127261 Cosmic; 1151774 Cosmic; 1175854 Cosmic; 1176599 Cosmic; 1191691 Cosmic; 1224367 Cosmic; 1226857 Cosmic; 1247870 Cosmic; 1281365 Cosmic; 1305336 Cosmic; 1330503 Cosmic; 1375587 Cosmic; 1483363 Cosmic; 1509201 Cosmic; 1523831 Cosmic; 1524793 Cosmic; 1639635 Cosmic; 1664520 Cosmic; 1760519 Cosmic; 1998437 Cosmic; 2165706 Cosmic; 2301560 Cosmic; 2361364 Cosmic; 2433754 Cosmic; 2458763 Cosmic; 2462863 Cosmic; 2602911 Cosmic; 2649235 Cosmic; 2649237 Cosmic; 2668294 IARC_TP53; 13197 IARC_TP53; 21218 Progenetix; CVCL_0207 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PXD005940
PRIDE; PXD005942 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Version number | 37 |