ID   CCRF-CEM
AC   CVCL_0207
SY   CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C
DR   BTO; BTO:0000736
DR   CLO; CLO_0002334
DR   CLO; CLO_0015478
DR   CLO; CLO_0050143
DR   EFO; EFO_0002128
DR   MCCL; MCC:0000096
DR   MCCL; MCC:0000097
DR   CLDB; cl675
DR   CLDB; cl676
DR   CLDB; cl677
DR   AddexBio; C0003001/32
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   ArrayExpress; E-MTAB-7721
DR   ArrayExpress; E-MTAB-7722
DR   ATCC; CCL-119
DR   ATCC; CRM-CCL-119
DR   ATCC; CRL-7916
DR   ATCC; CRL-8436
DR   BCRC; 60137
DR   BCRJ; 0063
DR   BioGRID_ORCS_Cell_line; 1318
DR   BioSample; SAMN00808493
DR   BioSample; SAMN01821675
DR   BioSample; SAMN03471121
DR   BioSample; SAMN03471203
DR   BioSample; SAMN03472050
DR   BioSample; SAMN03472700
DR   BioSample; SAMN03472808
DR   BioSample; SAMN03473385
DR   cancercelllines; CVCL_0207
DR   CCRID; 3101HUMTCHu147
DR   CCRID; 4201HUM-CCTCC00219
DR   CCTCC; GDC0219
DR   Cell_Model_Passport; SIDM00121
DR   ChEMBL-Cells; CHEMBL3307641
DR   ChEMBL-Targets; CHEMBL382
DR   ChEMBL-Targets; CHEMBL393
DR   CLS; 300147
DR   Coriell; GM03671
DR   Cosmic; 683716
DR   Cosmic; 721708
DR   Cosmic; 801728
DR   Cosmic; 846384
DR   Cosmic; 850198
DR   Cosmic; 875863
DR   Cosmic; 897449
DR   Cosmic; 905952
DR   Cosmic; 913411
DR   Cosmic; 919157
DR   Cosmic; 922674
DR   Cosmic; 932765
DR   Cosmic; 933544
DR   Cosmic; 974251
DR   Cosmic; 1012060
DR   Cosmic; 1037690
DR   Cosmic; 1044252
DR   Cosmic; 1070703
DR   Cosmic; 1071876
DR   Cosmic; 1092595
DR   Cosmic; 1115588
DR   Cosmic; 1118462
DR   Cosmic; 1127261
DR   Cosmic; 1151774
DR   Cosmic; 1175854
DR   Cosmic; 1176599
DR   Cosmic; 1191691
DR   Cosmic; 1224367
DR   Cosmic; 1226857
DR   Cosmic; 1247870
DR   Cosmic; 1281365
DR   Cosmic; 1305336
DR   Cosmic; 1330503
DR   Cosmic; 1375587
DR   Cosmic; 1483363
DR   Cosmic; 1509201
DR   Cosmic; 1523831
DR   Cosmic; 1524793
DR   Cosmic; 1639635
DR   Cosmic; 1664520
DR   Cosmic; 1760519
DR   Cosmic; 1998437
DR   Cosmic; 2165706
DR   Cosmic; 2301560
DR   Cosmic; 2361364
DR   Cosmic; 2433754
DR   Cosmic; 2458763
DR   Cosmic; 2462863
DR   Cosmic; 2602911
DR   Cosmic; 2649235
DR   Cosmic; 2649237
DR   Cosmic; 2668294
DR   Cosmic-CLP; 905952
DR   DepMap; ACH-001738
DR   DSMZ; ACC-240
DR   DSMZCellDive; ACC-240
DR   ECACC; 85112105
DR   EGA; EGAS00001000978
DR   GDSC; 905952
DR   GEO; GSM2116
DR   GEO; GSM50193
DR   GEO; GSM50257
DR   GEO; GSM236780
DR   GEO; GSM236816
DR   GEO; GSM743457
DR   GEO; GSM750806
DR   GEO; GSM799345
DR   GEO; GSM799408
DR   GEO; GSM1153416
DR   GEO; GSM1178011
DR   GEO; GSM1178012
DR   GEO; GSM1178013
DR   GEO; GSM1181330
DR   GEO; GSM1181347
DR   GEO; GSM1374445
DR   GEO; GSM1669670
DR   GEO; GSM2124653
DR   GEO; GSM5137708
DR   IARC_TP53; 13197
DR   IARC_TP53; 21218
DR   IGRhCellID; CCRFCEM
DR   IPD-IMGT/HLA; 10403
DR   IZSLER; BS TCL 11
DR   JCRB; IFO50412
DR   JCRB; JCRB0033
DR   JCRB; JCRB9023
DR   KCLB; 10119
DR   LINCS_LDP; LCL-1012
DR   Lonza; 647
DR   NCBI_Iran; C105
DR   NCI-DTP; CCRF-CEM
DR   PharmacoDB; CCRFCEM_190_2019
DR   PRIDE; PXD005940
DR   PRIDE; PXD005942
DR   PRIDE; PXD005946
DR   PRIDE; PXD023662
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_0207
DR   PubChem_Cell_line; CVCL_0207
DR   RCB; RCB1980
DR   SKY/M-FISH/CGH; 2784
DR   TKG; TKG 0563
DR   Wikidata; Q54809015
RX   CelloPub=CLPUB00447;
RX   DOI=10.1007/BF02618370;
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1086134;
RX   PubMed=2041050;
RX   PubMed=2140233;
RX   PubMed=2144611;
RX   PubMed=2255914;
RX   PubMed=2985879;
RX   PubMed=3159941;
RX   PubMed=3335022;
RX   PubMed=3495441;
RX   PubMed=3874327;
RX   PubMed=4363409;
RX   PubMed=5224274;
RX   PubMed=6198871;
RX   PubMed=6582512;
RX   PubMed=6600440;
RX   PubMed=6954533;
RX   PubMed=7630190;
RX   PubMed=7888679;
RX   PubMed=8127147;
RX   PubMed=8547074;
RX   PubMed=8641406;
RX   PubMed=9108419;
RX   PubMed=9290701;
RX   PubMed=9510473;
RX   PubMed=9557624;
RX   PubMed=9685479;
RX   PubMed=9738977;
RX   PubMed=9787181;
RX   PubMed=9823951;
RX   PubMed=9933131;
RX   PubMed=10071127;
RX   PubMed=10700174;
RX   PubMed=10739008;
RX   PubMed=10769646;
RX   PubMed=11226526;
RX   PubMed=11565033;
RX   PubMed=14278051;
RX   PubMed=14500364;
RX   PubMed=15472075;
RX   PubMed=15748285;
RX   PubMed=16408098;
RX   PubMed=17088437;
RX   PubMed=17117183;
RX   PubMed=17170727;
RX   PubMed=17308084;
RX   PubMed=19372543;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=20922763;
RX   PubMed=22068913;
RX   PubMed=22347499;
RX   PubMed=22384151;
RX   PubMed=22675565;
RX   PubMed=22628656;
RX   PubMed=23856246;
RX   PubMed=23933261;
RX   PubMed=24279929;
RX   PubMed=24670534;
RX   PubMed=25070259;
RX   PubMed=27377824;
RX   PubMed=27397505;
RX   PubMed=27807467;
RX   PubMed=28196595;
RX   PubMed=29718670;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31160637;
RX   PubMed=31394625;
RX   PubMed=35354797;
RX   PubMed=35839778;
WW   https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
WW   https://www.atcc.org/en/support/technical-support/faqs/normal-morphology-of-atcc-ccl-119
WW   https://strap.nci.nih.gov/celline_detail.php?sample_id=29
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-12.html
WW   http://www.cccells.org/cellreqs-ncipptp.php
WW   http://www.pptpinvitro.org/cell_lines_panel.php
WW   http://www.nibsc.org/Default.aspx?pageid=597&id=0005&theme=default
WW   https://tcpaportal.org/mclp/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: LL-100 blood cancer cell line panel.
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
CC   Part of: NCI-60 cancer cell line panel.
CC   Part of: NCI-7 clinical proteomics reference material cell line panel.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8436.
CC   Population: Caucasian.
CC   Doubling time: 23 hours (PubMed=17117183); 24 hours (PubMed=20922763); 22.0 hours (PubMed=25070259); ~24 hours (CLS=300147); ~24-30 hours (DSMZ=ACC-240); 26.7 hours (NCI-DTP=CCRF-CEM).
CC   HLA typing: B*08,40; C*03:04:01,07; DPB1*04:01,13:01; DQB1*02:01,02:02; DRB1*03:01:01,07:01 (PubMed=15748285).
CC   HLA typing: DPB1*04:01,13:01 (IPD-IMGT/HLA=10403).
CC   HLA typing: A*01:01:01,07:01:02; B*08:01:01,16:01:02; C*03:04:01,07:01:01; DPB1*04:01:01,13:XX; DQA1*02:01:01,05:01:01; DQB1*02:01:01,02:02:01; DRB1*03:01:01,07:01:01 (CLS=300147).
CC   HLA typing: A*01:01:01,31:01:02; B*08:01:01,40:01:02; C*03:04:01,07:01:01 (DSMZCellDive=ACC-240).
CC   Microsatellite instability: Instable (MSI-low) (PubMed=10739008; PubMed=11226526; PubMed=31068700; Sanger).
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (PubMed=14500364; PubMed=17308084).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (PubMed=11565033; Cosmic-CLP; DepMap).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (PubMed=17088437; Cosmic-CLP; DepMap).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=17088437; Cosmic-CLP; DepMap).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (PubMed=15472075).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (PubMed=15472075).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (PubMed=2144611; PubMed=10071127; PubMed=17088437; Cosmic-CLP; DepMap).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (PubMed=2144611; PubMed=10071127; PubMed=17088437; Cosmic-CLP; DepMap).
CC   Omics: Array-based CGH.
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Fluorescence phenotype profiling.
CC   Omics: Metabolome analysis.
CC   Omics: lncRNA expression profiling.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Proteome analysis by 2D-DE/MS.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0.2%; Native American=0.21%; East Asian, North=0.43%; East Asian, South=0.09%; South Asian=0.81%; European, North=69.4%; European, South=28.85% (PubMed=30894373).
CC   Discontinued: ATCC; CRL-7916; true.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
ST   Source(s): AddexBio; ATCC; CLS; Cosmic-CLP; DSMZ; ECACC; JCRB; KCLB; PubMed=19372543; PubMed=20922763; RCB
ST   Amelogenin: X
ST   CSF1PO: 9,10,11 (RCB)
ST   CSF1PO: 10,11 (AddexBio; ATCC_CCL-119; Cosmic-CLP; JCRB_IFO50412_JCRB9023; KCLB; PubMed=20922763)
ST   CSF1PO: 10,13 (ATCC_CRL-8436; CLS; DSMZ)
ST   CSF1PO: 11 (ECACC; JCRB_JCRB0033; PubMed=19372543)
ST   D13S317: 10,11,12 (RCB)
ST   D13S317: 11 (ATCC_CRL-8436; CLS; DSMZ)
ST   D13S317: 11,12 (AddexBio; ATCC_CCL-119; Cosmic-CLP; ECACC; JCRB; KCLB; PubMed=19372543; PubMed=20922763)
ST   D16S539: 10,13 (AddexBio; ATCC_CCL-119; ATCC_CRL-8436; CLS; Cosmic-CLP; DSMZ; ECACC; JCRB; PubMed=19372543; PubMed=20922763)
ST   D16S539: 10,13,14 (RCB)
ST   D18S51: 13 (DSMZ)
ST   D18S51: 13,18 (CLS)
ST   D19S433: 14,15
ST   D21S11: 30,33.2 (PubMed=19372543; PubMed=20922763)
ST   D21S11: 30,34.2 (CLS; DSMZ)
ST   D2S1338: 23,24 (DSMZ)
ST   D2S1338: 24 (PubMed=19372543; PubMed=20922763)
ST   D3S1358: 14,15 (CLS; DSMZ; KCLB)
ST   D3S1358: 15 (PubMed=19372543)
ST   D3S1358: 15,16 (PubMed=20922763)
ST   D5S818: 12,13 (AddexBio; ATCC_CCL-119; ATCC_CRL-8436; CLS; DSMZ; ECACC; KCLB; PubMed=19372543; PubMed=20922763; RCB)
ST   D5S818: 12,13,14 (Cosmic-CLP)
ST   D7S820: 9,12 (JCRB_JCRB0033)
ST   D7S820: 9,13 (AddexBio; ATCC_CCL-119; ATCC_CRL-8436; CLS; Cosmic-CLP; DSMZ; ECACC; JCRB_IFO50412_JCRB9023; KCLB; PubMed=19372543; PubMed=20922763; RCB)
ST   D8S1179: 12,13 (CLS; DSMZ; PubMed=20922763)
ST   D8S1179: 13 (PubMed=19372543)
ST   FGA: 22,23,24,25 (DSMZ)
ST   FGA: 23,24 (CLS; PubMed=20922763)
ST   FGA: 24 (PubMed=19372543)
ST   Penta D: 10,11
ST   Penta E: 5 (DSMZ)
ST   Penta E: 5,14 (CLS)
ST   TH01: 6,7
ST   TPOX: 7,8 (DSMZ)
ST   TPOX: 8 (AddexBio; ATCC_CCL-119; ATCC_CRL-8436; CLS; Cosmic-CLP; ECACC; JCRB; KCLB; PubMed=19372543; PubMed=20922763; RCB)
ST   vWA: 17,18,19 (DSMZ)
ST   vWA: 17,19 (AddexBio; ATCC_CCL-119; ATCC_CRL-8436; CLS; Cosmic-CLP; ECACC; JCRB; KCLB; PubMed=19372543; PubMed=20922763)
ST   vWA: 18,19 (RCB)
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 48
//
RX   CelloPub=CLPUB00447;
RA   Mulivor R.A., Suchy S.F.;
RT   "1992/1993 catalog of cell lines. NIGMS human genetic mutant cell
RT   repository. 16th edition. October 1992.";
RL   (In) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda (1992).
//
RX   DOI=10.1007/BF02618370;
RA   Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.;
RT   "The animal cell culture collection.";
RL   In Vitro 5:1-16(1970).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=1086134;
RA   Kaplan J., Peterson W.D. Jr.;
RT   "Detection of T-cell lymphoma-associated antigens on cord blood
RT   lymphocytes and phytohemagglutinin-stimulated blasts.";
RL   Cancer Res. 36:3471-3475(1976).
//
RX   PubMed=2041050; DOI=10.1093/jnci/83.11.757;
RA   Monks A., Scudiero D.A., Skehan P., Shoemaker R.H., Paull K.D.,
RA   Vistica D.T., Hose C.D., Langley J., Cronise P., Vaigro-Wolff A.,
RA   Gray-Goodrich M., Campbell H., Mayo J.G., Boyd M.R.;
RT   "Feasibility of a high-flux anticancer drug screen using a diverse
RT   panel of cultured human tumor cell lines.";
RL   J. Natl. Cancer Inst. 83:757-766(1991).
//
RX   PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x;
RA   Nakano A., Harada T., Morikawa S., Kato Y.;
RT   "Expression of leukocyte common antigen (CD45) on various human
RT   leukemia/lymphoma cell lines.";
RL   Acta Pathol. Jpn. 40:107-115(1990).
//
RX   PubMed=2144611; DOI=10.1128/mcb.10.10.5502-5509.1990;
RA   Cheng J., Haas M.;
RT   "Frequent mutations in the p53 tumor suppressor gene in human leukemia
RT   T-cell lines.";
RL   Mol. Cell. Biol. 10:5502-5509(1990).
//
RX   PubMed=2255914; DOI=10.1126/science.2255914;
RA   Aplan P.D., Lombardi D.P., Ginsberg A.M., Cossman J., Bertness V.L.,
RA   Kirsch I.R.;
RT   "Disruption of the human SCL locus by 'illegitimate' V-(D)-J
RT   recombinase activity.";
RL   Science 250:1426-1429(1990).
//
RX   PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0;
RA   Drexler H.G., Gaedicke G., Minowada J.;
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- 1.
RT   carboxylic esterase.";
RL   Leuk. Res. 9:209-229(1985).
//
RX   PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1;
RA   Drexler H.G., Gaedicke G., Minowada J.;
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- III.
RT   Beta-hexosaminidase (E.C. 3.2.1.30).";
RL   Leuk. Res. 9:549-559(1985).
//
RX   PubMed=3335022;
RA   Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J.,
RA   Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.;
RT   "Feasibility of drug screening with panels of human tumor cell lines
RT   using a microculture tetrazolium assay.";
RL   Cancer Res. 48:589-601(1988).
//
RX   PubMed=3495441; DOI=10.1002/eji.1830170503;
RA   Kanowith-Klein S., Saxon A., Uittenbogaart C.H.;
RT   "Constitutive production of B cell differentiation factor-like
RT   activity by human T and B cell lines.";
RL   Eur. J. Immunol. 17:593-598(1987).
//
RX   PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x;
RA   Drexler H.G., Gaedicke G., Minowada J.;
RT   "Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid
RT   phosphatase.";
RL   Leuk. Res. 9:537-548(1985).
//
RX   PubMed=4363409; DOI=10.1084/jem.139.5.1070;
RA   Kaplan J., Shope T.C., Peterson W.D. Jr.;
RT   "Epstein-Barr virus-negative human malignant T-cell lines.";
RL   J. Exp. Med. 139:1070-1076(1974).
//
RX   PubMed=5224274; DOI=10.1002/1097-0142(196611)19:11<1725::AID-CNCR2820191142>3.0.CO;2-T;
RA   Uzman B.G., Foley G.E., Farber S., Lazarus H.;
RT   "Morphologic variations in human leukemic lymphoblasts (CCRF-CEM
RT   cells) after long-term culture and exposure to chemotherapeutic
RT   agents. A study with the electron microscope.";
RL   Cancer 19:1725-1742(1966).
//
RX   PubMed=6198871; DOI=10.18926/AMO/32400;
RA   Oda T., Watanabe S., Nakamura T.;
RT   "Type C virus particles produced in human T-cell lines derived from
RT   acute lymphoblastic leukemia and a leukemic T-lymphoid malignancy.";
RL   Acta Med. Okayama 37:529-533(1983).
//
RX   PubMed=6582512; DOI=10.1073/pnas.81.2.568;
RA   Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.;
RT   "Cell surface antigens of human ovarian and endometrial carcinoma
RT   defined by mouse monoclonal antibodies.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).
//
RX   PubMed=6600440; DOI=10.1007/BF02617996;
RA   Uittenbogaart C.H., Cantor Y., Fahey J.L.;
RT   "Growth of human malignant lymphoid cell lines in serum-free medium.";
RL   In Vitro 19:67-72(1983).
//
RX   PubMed=6954533; DOI=10.1073/pnas.79.7.2194;
RA   Westin E.H., Gallo R.C., Arya S.K., Eva A., Souza L.M., Baluda M.A.,
RA   Aaronson S.A., Wong-Staal F.;
RT   "Differential expression of the amv gene in human hematopoietic
RT   cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982).
//
RX   PubMed=7630190;
RA   Zhou M.-X., Gu L.-B., James C.D., He J., Yeager A.M., Smith S.D.,
RA   Findley H.W.;
RT   "Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines
RT   established from children with acute lymphoblastic leukemia.";
RL   Leukemia 9:1159-1161(1995).
//
RX   PubMed=7888679; DOI=10.1182/blood.V85.6.1608.bloodjournal8561608;
RA   Zhou M.-X., Yeager A.M., Smith S.D., Findley H.W.;
RT   "Overexpression of the MDM2 gene by childhood acute lymphoblastic
RT   leukemia cells expressing the wild-type p53 gene.";
RL   Blood 85:1608-1614(1995).
//
RX   PubMed=8127147;
RA   Heyman M., Grander D., Brondum-Nielsen K., Cederblad B., Liu Y.,
RA   Xu B., Einhorn S.;
RT   "Interferon system defects in malignant T-cells.";
RL   Leukemia 8:425-434(1994).
//
RX   PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x;
RA   Siebert R., Willers C.P., Schramm A., Fossa A., Dresen I.M.G.,
RA   Uppenkamp M., Nowrousian M.R., Seeber S., Opalka B.;
RT   "Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and
RT   lymphoblastic leukaemia cell lines.";
RL   Br. J. Haematol. 91:350-354(1995).
//
RX   PubMed=8641406; DOI=10.1111/j.1600-0609.1996.tb00721.x;
RA   Borgonovo-Brandter L., Heyman M., Rasool O., Liu Y., Grander D.,
RA   Einhorn S.;
RT   "p16INK4/p15INK4B gene inactivation is a frequent event in malignant
RT   T-cell lines.";
RL   Eur. J. Haematol. 56:313-318(1996).
//
RX   PubMed=9108419; DOI=10.1182/blood.V89.8.2986;
RA   Findley H.W., Gu L.-B., Yeager A.M., Zhou M.-X.;
RT   "Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with
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