Cellosaurus CMK (CVCL_0216)

Cell line name CMK
Accession CVCL_0216
Resource Identification Initiative To cite this cell line use: CMK (RRID:CVCL_0216)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: ENCODE project common cell types; tier 3.
Doubling time: ~40-50 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Disease Childhood acute megakaryoblastic leukemia (NCIt: C7972)
Down syndrome (NCIt: C2993)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_0217 (CMK-11-5); CVCL_2804 (CMK-86)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX,Y
CSF1PO11,13
D13S31711
D16S5399,11
D5S81811,12
D7S82011,12
TH017
TPOX9,11
vWA18
Web pages http://genome.ucsc.edu/ENCODE/protocols/cell/human/CMK_Stam_protocol.pdf
Publications

PubMed=2527057; DOI=10.1111/j.1365-2141.1989.tb07681.x
Sato T., Fuse A., Eguchi M., Hayashi Y., Ryo R., Adachi M., Kishimoto Y., Teramura M., Mizoguchi H., Shima Y., Komori I., Sunami S., Okimoto Y., Nakajima H.
Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryoblastic leukaemia.
Br. J. Haematol. 72:184-190(1989)

PubMed=2665839
Komatsu N., Suda T., Moroi M., Tokuyama N., Sakata Y., Okada M., Nishida T., Hirai Y., Sato T., Fuse A., Miura Y.
Growth and differentiation of a human megakaryoblastic cell line, CMK.
Blood 74:42-48(1989)

PubMed=2217443
Miura Y., Komatsu N., Suda T.
Growth and differentiation of two human megakaryoblastic cell lines CMK and UT-7.
Prog. Clin. Biol. Res. 356:259-270(1990)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x
Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=10674912; DOI=10.3109/10428190009148861
Sato T., Sekine H., Kakuda H., Miura N., Sunohara M., Fuse A.
HIV infection of megakaryocytic cell lines.
Leuk. Lymphoma 36:397-404(2000)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23325432; DOI=10.1101/gr.147942.112
Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=23955599; DOI=10.1038/ng.2731
Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-392
Cell line databases/resources CCLE; CMK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 910566
GDSC; 910566
LINCS_LDP; LCL-1051
TOKU-E; 4113
Ontologies BTO; BTO:0000978
CLO; CLO_0002526
EFO; EFO_0003037
MCCL; MCC:0000105
Biological sample resources BioSample; SAMN03473574
ENCODE; ENCBS071ENC
Chemistry resources ChEMBL-Cells; CHEMBL3308149
ChEMBL-Targets; CHEMBL2366177
Gene expression databases GEO; GSM236781
GEO; GSM236817
GEO; GSM510583
GEO; GSM886938
GEO; GSM888005
GEO; GSM1374449
Polymorphism and mutation databases Cosmic; 787423
Cosmic; 910566
Cosmic; 919131
Cosmic; 975241
Cosmic; 1012061
Cosmic; 1070695
Cosmic; 1176598
Cosmic; 1191081
Cosmic; 1191702
Cosmic; 1281307
Cosmic; 1286955
Cosmic; 1315742
Cosmic; 1524829
Cosmic; 1559970
Cosmic; 2089668
Cosmic; 2131535
Cosmic; 2306202