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Cellosaurus CMK-11-5 (CVCL_0217)

[Text version]

Cell line name CMK-11-5
Synonyms CMK 11-5; CMK11-5; CMK115
Accession CVCL_0217
Resource Identification Initiative To cite this cell line use: CMK-11-5 (RRID:CVCL_0217)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~2 days (lot 12122008), ~34 hours (lot 12082016) (JCRB).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations TP53-FXR2 gene fusion (PubMed=16778363).
Heterozygous for TP53 p.Asp49His (c.145G>C) (PubMed=16778363).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.58
Native American0
East Asian, North95.47
East Asian, South0
South Asian0
European, North0
European, South3.94
Disease Down syndrome (NCIt: C2993)
Myeloid leukemia associated with Down syndrome (NCIt: C43223)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2804 (CMK-86)
Sex of cell Male
Age at sampling 10M
Category Cancer cell line
STR profile Source(s): JCRB

Markers:
AmelogeninX,Y
CSF1PO11,13
D5S81811,12
D7S82011,12
D13S31711
D16S5399,11
TH017
TPOX9,11
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=1991165
Sakaguchi M., Sato T., Groopman J.E.
Human immunodeficiency virus infection of megakaryocytic cells.
Blood 77:481-485(1991)

PubMed=1391807
Nagano T., Ohga S., Kishimoto Y., Kimura T., Yasunaga K., Adachi M., Ryo R., Sato T.
Ultrastructural analysis of platelet-like particles from a human megakaryocytic leukemia cell line (CMK 11-5).
Int. J. Hematol. 56:67-78(1992)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=16778363; DOI=10.1620/tjem.209.169
Kanezaki R., Toki T., Xu G., Narayanan R., Ito E.
Cloning and characterization of the novel chimeric gene p53/FXR2 in the acute megakaryoblastic leukemia cell line CMK11-5.
Tohoku J. Exp. Med. 209:169-180(2006)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections JCRB; IFO50430
Cell line databases/resources CCLE; CMK115_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM01235
DepMap; ACH-001036
Ontologies MCCL; MCC:0000106
Biological sample resources BioSample; SAMN10987844
Chemistry resources PharmacoDB; CMK115_211_2019
Gene expression databases GEO; GSM886937
GEO; GSM888003
Other Wikidata; Q54813771
Polymorphism and mutation databases IARC_TP53; 28399
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number16