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Cellosaurus COLO 320DM (CVCL_0219)

[Text version]

Cell line name COLO 320DM
Synonyms COLO-320DM; COLO_320DM; COLO-320-DM; COLO #320DM; COLO320/DM; COLO320-DM; COLO320DM; Colo320DM; COLO320 DM; COLO 320 DM; Colorado 320 Double Minutes
Accession CVCL_0219
Resource Identification Initiative To cite this cell line use: COLO 320DM (RRID:CVCL_0219)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: COLD-320-DM; In Cosmic 1466812.
Derived from sampling site: Colon; sigmoid.
Sequence variations APC p.Ser811Ter (c.2432C>G) (PubMed=24755471; PubMed=28179481).
TP53 p.Arg248Trp (c.742C>T) (ClinVar=VCV000012347) (PubMed=7651727; PubMed=16418264; PubMed=24755471).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1989 (COLO 320)
Children:
CVCL_XD07 (COLO 320DM-EGFP)CVCL_XD08 (COLO 320DM-RFP)CVCL_1990 (COLO 320DMF)
CVCL_0220 (COLO 320HSR)CVCL_F641 (COLO 587)
Sex of cell Female
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): ATCC; CCRID; CLS; ECACC; JCRB; KCLB; PubMed=25877200; PubMed=25926053

Markers:
AmelogeninX
CSF1PO11 (ATCC; CCRID; CLS; JCRB; KCLB; PubMed=25877200; PubMed=25926053)
11,12 (ECACC)
D2S133818,25
D3S135817
D5S81812
D7S8209,12
D8S117913
D13S31711
D16S53911,12
D18S5115
D19S43316.2
D21S1131,33.2 (PubMed=25926053)
33.2 (CCRID; CLS; PubMed=25877200)
FGA20
Penta D9,12
Penta E11
TH018,9 (ECACC)
9 (ATCC; CCRID; CLS; JCRB; KCLB; PubMed=25877200; PubMed=25926053)
TPOX8,9
vWA15,18

Run an STR similarity search on this cell line
Web pages http://tcpaportal.org/mclp/
http://www.cellresource.cn/fdetail.aspx?id=133
http://www.cellresource.cn/fdetail.aspx?id=585
http://www.cellresource.cn/fdetail.aspx?id=810
http://www.cellresource.cn/fdetail.aspx?id=1713
Publications

PubMed=498117
Quinn L.A., Moore G.E., Morgan R.T., Woods L.K.
Cell lines from human colon carcinoma with unusual cell products, double minutes, and homogeneously staining regions.
Cancer Res. 39:4914-4924(1979)

PubMed=7874267; DOI=10.1007/BF02349278
Ikuta S., Itoh F., Hinoda Y., Toyota M., Makiguchi Y., Imai K., Yachi A.
Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma.
J. Gastroenterol. 29:727-732(1994)

PubMed=7651727
Kastrinakis W.V., Ramchurren N., Rieger K.M., Hess D.T., Loda M., Steele G., Summerhayes I.C.
Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression.
Oncogene 11:647-652(1995)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=16418264; DOI=10.1073/pnas.0510146103
Liu Y., Bodmer W.F.
Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=18258742; DOI=10.1073/pnas.0712176105
Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=19927377; DOI=10.1002/gcc.20730
Knutsen T., Padilla-Nash H.M., Wangsa D., Barenboim-Stapleton L., Camps J., McNeil N.E., Difilippantonio M.J., Ried T.
Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines.
Genes Chromosomes Cancer 49:204-223(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780
Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=22538498; DOI=10.1159/000338793
Grozinsky-Glasberg S., Shimon I., Rubinfeld H.
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)

PubMed=23272949; DOI=10.1186/1755-8794-5-66
Schlicker A., Beran G., Chresta C.M., McWalter G., Pritchard A., Weston S., Runswick S., Davenport S., Heathcote K., Castro D.A., Orphanides G., French T., Wessels L.F.A.
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66-66(2012)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S., Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S., O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F., Mariadason J.M., Sieber O.M.
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002-7002(2015)

PubMed=28179481; DOI=10.1158/1535-7163.MCT-16-0578
Tanaka N., Mashima T., Mizutani A., Sato A., Aoyama A., Gong B., Yoshida H., Muramatsu Y., Nakata K., Matsuura M., Katayama R., Nagayama S., Fujita N., Sugimoto Y., Seimiya H.
APC mutations as a potential biomarker for sensitivity to tankyrase inhibitors in colorectal cancer.
Mol. Cancer Ther. 16:752-762(2017)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29101300; DOI=10.15252/msb.20177701
Frejno M., Zenezini Chiozzi R., Wilhelm M., Koch H., Zheng R., Klaeger S., Ruprecht B., Meng C., Kramer K., Jarzab A., Heinzlmeir S., Johnstone E., Domingo E., Kerr D., Jesinghaus M., Slotta-Huspenina J., Weichert W., Knapp S., Feller S.M., Kuster B.
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)

Cross-references
Cell line collections ATCC; CCL-220
BCRC; 60108
CCTCC; GDC0042
CLS; 300153/p521_Colo-320_DM
ECACC; 87061205
JCRB; JCRB0225
KCB; KCB 200694YJ
KCLB; 10220
Cell line databases/resources CLDB; cl827
CCRID; 3111C0001CCC000133
CCRID; 3131C0001000700014
CCRID; 3131C0001000700208
CCRID; 3142C0001000000042
ColonAtlas; COLO320DM
LINCS_LDP; LCL-1197
SKY/M-FISH/CGH; 5014
TOKU-E; 985
Ontologies CLO; CLO_0002546
EFO; EFO_0002136
MCCL; MCC:0000108
Biological sample resources BioSample; SAMN03471612
Chemistry resources ChEMBL-Cells; CHEMBL3307647
ChEMBL-Targets; CHEMBL614562
PharmacoDB; COLO320DM_216_2019
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM206461
GEO; GSM274777
GEO; GSM513909
GEO; GSM514187
GEO; GSM739989
GEO; GSM739990
GEO; GSM739991
GEO; GSM740012
GEO; GSM784007
GEO; GSM827245
GEO; GSM1346834
GEO; GSM1374454
GEO; GSM1374455
GEO; GSM1448173
Other Wikidata; Q54814089
Polymorphism and mutation databases Cosmic; 808509
Cosmic; 1043807
Cosmic; 1223136
Cosmic; 1310932
Cosmic; 1312298
Cosmic; 1374635
Cosmic; 1466812
Cosmic; 2301969
Cosmic; 2668253
Cosmic; 2664052
Cosmic; 2760069
Cosmic; 2811047
IARC_TP53; 4553
Progenetix; CVCL_0219
Proteomic databases PRIDE; PXD005354
Entry history
Entry creation04-Apr-2012
Last entry update29-Oct-2020
Version number30