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Cellosaurus COLO 320HSR (CVCL_0220)

[Text version]

Cell line name COLO 320HSR
Synonyms COLO-320HSR; COLO320HSR; COLO 320 HSR; COLO-320-HSR; COLO-HSR
Accession CVCL_0220
Resource Identification Initiative To cite this cell line use: COLO 320HSR (RRID:CVCL_0220)
Comments Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (PubMed=25926053; Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative phosphoproteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations APC p.Ser811Ter (c.2432C>G) (from parent cell line).
TP53 p.Arg248Trp (c.742C>T) (from parent cell line).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American2.14
East Asian, North0.47
East Asian, South2.14
South Asian10.52
European, North6.29
European, South78.44
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0219 (COLO 320DM)
Sex of cell Female
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; KCLB; PubMed=25877200; PubMed=25926053

Markers:
AmelogeninX
CSF1PO11
D3S135817
D5S81812
D7S8209,12
D8S117913
D13S31711
D16S53911,12
D18S5115
D21S1131,33.2
FGA20
Penta D9,12
Penta E11,13
TH018,9
TPOX8,9
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=498117
Quinn L.A., Moore G.E., Morgan R.T., Woods L.K.
Cell lines from human colon carcinoma with unusual cell products, double minutes, and homogeneously staining regions.
Cancer Res. 39:4914-4924(1979)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002-7002(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28854368; DOI=10.1016/j.celrep.2017.08.010
Roumeliotis T.I., Williams S.P., Goncalves E., Alsinet C., Del Castillo Velasco-Herrera M., Aben N., Ghavidel F.Z., Michaut M., Schubert M., Price S., Wright J.C., Yu L., Yang M., Dienstmann R., Guinney J., Beltrao P., Brazma A., Pardo M., Stegle O., Adams D.J., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.
Genomic determinants of protein abundance variation in colorectal cancer cells.
Cell Rep. 20:2201-2214(2017)

PubMed=29444439; DOI=10.1016/j.celrep.2018.01.051
Yuan T.L., Amzallag A., Bagni R., Yi M., Afghani S., Burgan W., Fer N., Strathern L.A., Powell K., Smith B., Waters A.M., Drubin D., Thomson T., Liao R., Greninger P., Stein G.T., Murchie E., Cortez E., Egan R.K., Procter L., Bess M., Cheng K.T., Lee C.-S., Lee L.C., Fellmann C., Stephens R., Luo J., Lowe S.W., Benes C.H., McCormick F.
Differential effector engagement by oncogenic KRAS.
Cell Rep. 22:1889-1902(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections ATCC; CCL-220.1
BCRC; 60109
ECACC; 87101501
KCLB; 10220.1
Cell line databases/resources CLDB; cl832
CLDB; cl833
Cell_Model_Passport; SIDM00842
ColonAtlas; COLO320HSR
Cosmic-CLP; 910569
DepMap; ACH-002219
GDSC; 910569
IGRhCellID; COLO320HSR
LINCS_LDP; LCL-1189
TOKU-E; 986
Ontologies CLO; CLO_0002547
EFO; EFO_0002137
MCCL; MCC:0000109
Biological sample resources BioSample; SAMN03473155
Chemistry resources ChEMBL-Cells; CHEMBL3308337
ChEMBL-Targets; CHEMBL2366265
PharmacoDB; COLO320HSR_223_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM206462
GEO; GSM274778
GEO; GSM784008
GEO; GSM843491
GEO; GSM1448182
GEO; GSM1669685
Other Wikidata; Q54814091
Polymorphism and mutation databases Cosmic; 720341
Cosmic; 808508
Cosmic; 910569
Cosmic; 1609506
Cosmic; 1995369
Proteomic databases PRIDE; PXD005235
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number26