Cellosaurus cell line Caco-2/TC-7 (CVCL_0233)

• Mutation; HGNC; 583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; 6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; 11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
  

PubMed=8175910; DOI=10.1242/jcs.107.1.213
Chantret I., Rodolosse A., Barbat A., Dussaulx E., Brot-Laroche E., Zweibaum A., Rousset M.
Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line Caco-2: evidence for glucose-dependent negative regulation.
J. Cell Sci. 107:213-225(1994)

DOI=10.1016/0378-5173(94)00280-I
Caro I., Boulenc X., Rousset M., Meunier V., Bourrie M., Julian B., Joyeux H., Roques C., Berger Y., Zweibaum A., Fabre G.
Characterisation of a newly isolated Caco-2 clone (TC-7), as a model of transport processes and biotransformation of drugs.
Int. J. Pharmaceut. 116:147-158(1995)

PubMed=14599474; DOI=10.1016/S0887-2333(03)00095-X
Ranaldi G., Consalvo R., Sambuy Y., Scarino M.L.
Permeability characteristics of parental and clonal human intestinal Caco-2 cell lines differentiated in serum-supplemented and serum-free media.
Toxicol. In Vitro 17:761-767(2003)

PubMed=15868485; DOI=10.1007/s10565-005-0085-6
Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A., Zucco F.
The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics.
Cell Biol. Toxicol. 21:1-26(2005)