Cell line name | DG-75 | ||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Synonyms | D.G.-75; DG 75; DG75 | ||||||||||||||||||||||||||||
Accession | CVCL_0244 | ||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: DG-75 (RRID:CVCL_0244) | ||||||||||||||||||||||||||||
Comments | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: MD Anderson Cell Lines Project. Population: Jewish; Ashkenazi. Characteristics: EBV-negative. Characteristics: Infected by the DG-75 retrovirus, a replication-competent, murine leukemia-related retrovirus. Constitutively produces the virus. Doubling time: 18-20 hours (PubMed=188769); ~40-50 hours (DSMZ). Microsatellite instability: Instable (MSI-high) (PubMed=9583678; PubMed=31068700; Sanger). Omics: Deep exome analysis. Omics: DNA methylation analysis. Omics: Protein expression by reverse-phase protein arrays. Omics: Proteome analysis by 2D-DE/MS. Omics: SNP array analysis. Omics: Transcriptome analysis. Derived from sampling site: Pleural effusion. | ||||||||||||||||||||||||||||
Sequence variations | Homozygous for BAX p.Glu41Argfs*19 (c.121delG) (ClinVar=VCV000009512) (PubMed=9583678).Heterozygous for TP53 p.Arg283His (c.848G>A) (ClinVar=VCV000142324) (PubMed=9525742). | ||||||||||||||||||||||||||||
Genome ancestry | Source: PubMed=30894373
| ||||||||||||||||||||||||||||
Disease | Burkitt lymphoma (NCIt: C2912) Burkitt lymphoma (ORDO: Orphanet_543) | ||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
| ||||||||||||||||||||||||||||
Sex of cell | Male | ||||||||||||||||||||||||||||
Age at sampling | 10Y | ||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||
STR profile | Source(s): ATCC; Cosmic-CLP; DSMZ; PubMed=17254797 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||
Web pages | http://tcpaportal.org/mclp/ | ||||||||||||||||||||||||||||
Publications | PubMed=188769; DOI=10.1002/ijc.2910190105 PubMed=8558920 PubMed=8896424; DOI=10.1182/blood.V88.9.3562.bloodjournal8893562 PubMed=9473234; DOI=10.1182/blood.V91.5.1680 PubMed=9525742; DOI=10.1038/sj.onc.1201699 PubMed=9583678; DOI=10.1038/sj.onc.1201704 PubMed=9685479; DOI=10.1093/nar/26.16.3651 PubMed=9770427; DOI=10.1006/viro.1998.9363 PubMed=11425244; DOI=10.1002/1522-2683(200105)22:9<1867::AID-ELPS1867>3.0.CO;2-7 PubMed=12706092; DOI=10.1016/S0042-6822(02)00074-0 PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001 PubMed=20164919; DOI=10.1038/nature08768 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 PubMed=24590883; DOI=10.1002/gcc.22161 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 PubMed=31068700; DOI=10.1038/s41586-019-1186-3 | ||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||
Cell line collections | ATCC; CRL-2625
DSMZ; ACC-83 NCBI_Iran; C495 | ||||||||||||||||||||||||||||
Cell line databases/resources | CLDB; cl1051
CCLE; DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE Cell_Model_Passport; SIDM00948 CGH-DB; 9196-4 Cosmic-CLP; 906838 DepMap; ACH-002232 IGRhCellID; DG75 LINCS_LDP; LCL-2019 TOKU-E; 3578 | ||||||||||||||||||||||||||||
Ontologies | BTO; BTO:0003637
CLO; CLO_0002767 EFO; EFO_0002160 MCCL; MCC:0000134 | ||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03471755
BioSample; SAMN03473403 | ||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3308527
ChEMBL-Targets; CHEMBL2366199 GDSC; 906838 PharmacoDB; DG75_290_2019 | ||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783 ArrayExpress; E-MTAB-3610 GEO; GSM710428 GEO; GSM710444 GEO; GSM827239 GEO; GSM1669731 | ||||||||||||||||||||||||||||
Other | Wikidata; Q54831039 | ||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 906838
Cosmic; 931103 Cosmic; 1086327 Cosmic; 1118471 Cosmic; 1191698 Cosmic; 1588563 IARC_TP53; 8094 Progenetix; CVCL_0244 | ||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||||||||||||
Version number | 30 |