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Cellosaurus EoL-1 (CVCL_0258)

[Text version]

Cell line name EoL-1
Synonyms EOL-1; EOL1; EoL-1-cell; EoL-1 cell; AML-EOL-1
Accession CVCL_0258
Resource Identification Initiative To cite this cell line use: EoL-1 (RRID:CVCL_0258)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~60 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.14
Native American0
East Asian, North2.93
East Asian, South0
South Asian0
European, North52.17
European, South43.75
Disease Chronic eosinophilic leukemia, not otherwise specified (NCIt: C4563)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_S960 ! EoL-2
CVCL_4069 ! EoL-3
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; ECACC; PubMed=25877200; RCB; TKG

Markers:
AmelogeninX,Y
CSF1PO7,10
D3S135816,17
D5S81811
D7S82010,13
D8S117913
D13S31712,13
D16S5398,10
D18S5112,14
D21S1129
FGA24
Penta D7,11
Penta E5,7
TH019.3
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=2415185
Saito H., Bourinbaiar A., Ginsburg M., Minato K., Ceresi E., Yamada K., Machover D., Breard J., Mathe G.
Establishment and characterization of a new human eosinophilic leukemia cell line.
Blood 66:1233-1240(1985)

PubMed=1477652; DOI=10.3109/10428199209053629
Mayumi M.
EoL-1, a human eosinophilic cell line.
Leuk. Lymphoma 7:243-250(1992)

DOI=10.11418/jtca1981.15.4_211
Matsuo Y., Okochi A., Ariyasu T., Iimura E., Ohno T.
Identification of cell lines with variable numbers of tandem repeat (VNTR) amplified by polymerase chain reaction.
Tissue Cult. Res. Commun. 15:211-219(1996)

PubMed=8558913
Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M., Imaizumi M., Endo M., Takano N., Konno T.
Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
Leukemia 10:102-105(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=14630792; DOI=10.1182/blood-2003-07-2479
Cools J., Quentmeier H., Huntly B.J., Marynen P., Griffin J.D., Drexler H.G., Gilliland D.G.
The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia.
Blood 103:2802-2805(2004)

PubMed=14671638; DOI=10.1038/sj.leu.2403236
Drexler H.G., Quentmeier H., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.
Leukemia 18:227-232(2004)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940-940(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections DSMZ; ACC-386
ECACC; 94042252
RCB; RCB0641
RCB; RCB3679 - Discontinued
TKG; TKG 0476
Cell line databases/resources CLDB; cl1166
CCLE; EOL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM00277
Cosmic-CLP; 906856
GDSC; 906856
Ontologies BTO; BTO:0002405
CLO; CLO_0002932
CLO; CLO_0002933
CLO; CLO_0050996
MCCL; MCC:0000149
Biological sample resources BioSample; SAMN01821624
BioSample; SAMN03473158
Chemistry resources ChEMBL-Cells; CHEMBL3308381
ChEMBL-Targets; CHEMBL614489
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM887006
GEO; GSM888075
GEO; GSM1374475
GEO; GSM1446733
GEO; GSM1669766
Other Wikidata; Q54832338
Polymorphism and mutation databases Cosmic; 787428
Cosmic; 798671
Cosmic; 906856
Cosmic; 975246
Cosmic; 994180
Cosmic; 999731
Cosmic; 1012065
Cosmic; 1278780
Cosmic; 1623638
Cosmic; 2131562
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number25