ID   FL5.12
AC   CVCL_0262
SY   FL5.12A; Fetal Liver clone 5.12
DR   BTO; BTO:0003328
DR   MCCL; MCC:0000153
DR   BioGRID_ORCS_Cell_line; 1592
DR   ChEMBL-Cells; CHEMBL4295395
DR   ChEMBL-Targets; CHEMBL4296414
DR   Lonza; 259
DR   PubChem_Cell_line; CVCL_0262
DR   Wikidata; Q54834972
RX   PubMed=3933007;
RX   PubMed=8358790;
RX   PubMed=8798452;
RX   PubMed=10200549;
RX   PubMed=11486081;
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=FL5%2e12
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/f/cell-lines-detail-468.html
CC   Characteristics: IL3 dependent.
CC   Derived from site: In situ; Embryonic liver; UBERON=UBERON_0002107.
CC   Cell type: Pro-B cell; CL=CL_0000826.
CC   Breed/subspecies: BALB/c.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   13FD
CA   Factor-dependent cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 17
//
RX   PubMed=3933007; DOI=10.1073/pnas.82.21.7414;
RA   McKearn J.P., McCubrey J.A., Fagg B.;
RT   "Enrichment of hematopoietic precursor cells and cloning of
RT   multipotential B-lymphocyte precursors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:7414-7418(1985).
//
RX   PubMed=8358790; DOI=10.1016/0092-8674(93)90509-O;
RA   Oltvai Z.N., Milliman C.L., Korsmeyer S.J.;
RT   "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that
RT   accelerates programmed cell death.";
RL   Cell 74:609-619(1993).
//
RX   PubMed=8798452; DOI=10.1074/jbc.271.37.22764;
RA   Simonian P.L., Grillot D.A.M., Merino R., Nunez G.;
RT   "Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell
RT   death independently of its heterodimerization with Bcl-XL.";
RL   J. Biol. Chem. 271:22764-22772(1996).
//
RX   PubMed=10200549; DOI=10.1038/sj.cdd.4400452;
RA   Bojes H.K., Feng X., Kehrer J.P., Cohen G.M.;
RT   "Apoptosis in hematopoietic cells (FL5.12) caused by interleukin-3
RT   withdrawal: relationship to caspase activity and the loss of
RT   glutathione.";
RL   Cell Death Differ. 6:61-70(1999).
//
RX   PubMed=11486081; DOI=10.1126/science.1061075;
RA   Devireddy L.R., Teodoro J.G., Richard F.A., Green M.R.;
RT   "Induction of apoptosis by a secreted lipocalin that is
RT   transcriptionally regulated by IL-3 deprivation.";
RL   Science 293:829-834(2001).
//