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Cellosaurus FRTL-5 (CVCL_0265)

[Text version]

Cell line name FRTL-5
Synonyms FRTL 5; FRTL5; FRTL-5 Cl 2
Accession CVCL_0265
Resource Identification Initiative To cite this cell line use: FRTL-5 (RRID:CVCL_0265)
Comments Doubling time: 34 hours (CelloPub=CLPUB00429).
Derived from sampling site: Thyroid.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Fischer.
Hierarchy Parent: CVCL_5753 (FRTL)
Children:
CVCL_UG77 (FRTL-5 AG1)CVCL_UG78 (FRTL-5 AG2)CVCL_VG49 (FRTL-5 Miami)
Age at sampling 6W
Category Spontaneously immortalized cell line
Publications

PubMed=6327870; DOI=10.1677/joe.0.1010269
Bidey S.P., Chiovato L., Day A., Turmaine M., Gould R.P., Ekins R.P., Marshall N.J.
Evaluation of the rat thyroid cell strain FRTL-5 as an in-vitro bioassay system for thyrotrophin.
J. Endocrinol. 101:269-276(1984)

Patent=US4608341
Ambesi-Impiombato F.S.
Living, fast-growing thyroid cell strain, FRTL-5.
Patent number US4608341, 26-Aug-1986

PubMed=3670314; DOI=10.1128/MCB.7.9.3365
Fusco A., Berlingieri M.T., Di Fiore P.P., Portella G., Grieco M., Vecchio G.
One- and two-step transformations of rat thyroid epithelial cells by retroviral oncogenes.
Mol. Cell. Biol. 7:3365-3370(1987)

PubMed=2545492; DOI=10.1016/0303-7207(89)90020-8
Sugawa H., Mori T., Imura H.
Establishment of 8-azaguanine-resistant mutants from rat thyroid cell line FRTL-5.
Mol. Cell. Endocrinol. 62:319-326(1989)

CLPUB00429
Gerber H., Peter H.-J., Bosiger J., Studer H., Drews R., Ferguson D.C., Peterson M.E., Becker D.V.
Different continuous cell lines from adenomatous feline goiters widely differ in morphologic, functional and growth parameters.
(In) Progress in thyroid research. Proceedings of the 10th International Thyroid Conference; Gordon A., Gross J., Hennemann G. (eds.); pp.541-544; A A Balkema Publishers; Rotterdam (1991)

CLPUB00430
Peter H.-J., Gerber H., Studer H., Groscurth P., Zakarija M.
Thyroid cell lines forming follicle-like lumina in vitro.
(In) Progress in thyroid research. Proceedings of the 10th International Thyroid Conference; Gordon A., Gross J., Hennemann G. (eds.); pp.579-582; A A Balkema Publishers; Rotterdam (1991)

PubMed=1726925
Gerber H., Peter H.-J., Asmis L., Studer H.
Thyroid cell lines in research on goitrogenesis.
Thyroidology 3:115-118(1991)

PubMed=1846098; DOI=10.1210/endo-128-1-211
Peter H.-J., Gerber H., Studer H., Groscurth P., Zakarija M.
Comparison of FRTL-5 cell growth in vitro with that of xenotransplanted cells and the thyroid of the recipient mouse.
Endocrinology 128:211-219(1991)

PubMed=7836899; DOI=10.1677/joe.0.1430527
MacNeil S., Munro D.S., Metcalfe R., Cotterell S., Ruban L., Davies R., Weetman A.P.
An investigation of the ability of TSH and Graves' immunoglobulin G to increase intracellular calcium in human thyroid cells, rat FRTL-5 thyroid cells and eukaryotic cells transfected with the human TSH receptor.
J. Endocrinol. 143:527-540(1994)

PubMed=7912172; DOI=10.1111/j.1365-2265.1994.tb03017.x
Michelangeli V.P., Munro D.S., Poon C.W., Frauman A.G., Colman P.G.
Measurement of thyroid stimulating immunoglobulins in a new cell line transfected with a functional human TSH receptor (JPO9 cells), compared with an assay using FRTL-5 cells.
Clin. Endocrinol. (Oxf.) 40:645-652(1994)

PubMed=9709917; DOI=10.1089/thy.1998.8.623
Tasevski V., Benn D., Peters G., Luttrell B., Simpson A.
The Fischer rat thyroid cell line FRTL-5 exhibits a nondiploid karyotype.
Thyroid 8:623-626(1998)

PubMed=20151827; DOI=10.1089/thy.2009.0171
Sebai H., Hovsepian S., Ristorcelli E., Aouani E., Lombardo D., Fayet G.
Resveratrol increases iodide trapping in the rat thyroid cell line FRTL-5.
Thyroid 20:195-203(2010)

DOI=10.1128/MCB.00663-17
Fusco A., Berlingieri M.T., Di Fiore P.P., Portella G., Grieco M., Vecchio G.
Retraction for Fusco et al., 'One- and two-step transformations of rat thyroid epithelial cells by retroviral oncogenes'.
Mol. Cell. Biol. 38:e00663.17-e00663.17(2018)

Cross-references
Cell line collections ATCC; CRL-8305 - Discontinued
CLS; 500407/p559_FRTL-5
ECACC; 91030711
Cell line databases/resources CLDB; cl1395
Ontologies BTO; BTO:0001875
CLO; CLO_0003396
MCCL; MCC:0000156
Chemistry resources ChEMBL-Cells; CHEMBL3308088
ChEMBL-Targets; CHEMBL613879
Other Wikidata; Q54835180
Entry history
Entry creation04-Apr-2012
Last entry updated12-Mar-2020
Version number16