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Cellosaurus GEO (CVCL_0271)

Cell line name GEO
Synonyms Geo; HCT-GEO; HCT GEO
Accession CVCL_0271
Resource Identification Initiative To cite this cell line use: GEO (RRID:CVCL_0271)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Instable (MSI) (PubMed=25926053).
Omics: Deep exome analysis.
Omics: Deep quantitative phosphoproteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Transcriptome analysis.
Sequence variations KRAS p.Gly12Ala (c.35G>C) (PubMed=20570890).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=25926053

Markers:
AmelogeninX
D13S3178,12
D16S53912
D21S1129
D5S81812
D7S82010,11,11.1
TH018
TPOX8
vWA15
Publications

PubMed=7329817
Brattain M.G., Brattain D.E., Fine W.D., Khaled F.M., Marks M.E., Kimball P.M., Arcolano L.A., Danbury B.H.
Initiation and characterization of cultures of human colonic carcinoma with different biological characteristics utilizing feeder layers of confluent fibroblasts.
Oncodev. Biol. Med. 2:355-366(1981)

PubMed=6578361; DOI=10.1093/jnci/71.4.663
Marks M.E., Danbury B.H., Miller C.A. III, Brattain M.G.
Cell surface proteins and glycoproteins from biologically different human colon carcinoma cell lines.
J. Natl. Cancer Inst. 71:663-671(1983)

PubMed=2835152
Boyd D., Florent G., Kim P., Brattain M.G.
Determination of the levels of urokinase and its receptor in human colon carcinoma cell lines.
Cancer Res. 48:3112-3116(1988)

PubMed=3349466
Chantret I., Barbat A., Dussaulx E., Brattain M.G., Zweibaum A.
Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines.
Cancer Res. 48:1936-1942(1988)

PubMed=7761852; DOI=10.1126/science.7761852
Markowitz S.D., Wang J., Myeroff L., Parsons R., Sun L., Lutterbaugh J., Fan R.S., Zborowska E., Kinzler K.W., Vogelstein B., Brattain M.G., Willson J.K.V.
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.
Science 268:1336-1338(1995)

PubMed=17363507; DOI=10.1158/1535-7163.MCT-06-0555
Wang J., Kuropatwinski K., Hauser J., Rossi M.R., Zhou Y., Conway A., Kan J.L.C., Gibson N.W., Willson J.K.V., Cowell J.K., Brattain M.G.
Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis.
Mol. Cancer Ther. 6:1143-1150(2007)

PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192
Janakiraman M., Vakiani E., Zeng Z., Pratilas C.A., Taylor B.S., Chitale D., Halilovic E., Wilson M., Huberman K., Ricarte Filho J.C., Persaud Y., Levine D.A., Fagin J.A., Jhanwar S.C., Mariadason J.M., Lash A., Ladanyi M., Saltz L.B., Heguy A., Paty P.B., Solit D.B.
Genomic and biological characterization of exon 4 KRAS mutations in human cancer.
Cancer Res. 70:5901-5911(2010)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002-7002(2015)

PubMed=28854368; DOI=10.1016/j.celrep.2017.08.010
Roumeliotis T.I., Williams S.P., Goncalves E., Alsinet C., Del Castillo Velasco-Herrera M., Aben N., Ghavidel F.Z., Michaut M., Schubert M., Price S., Wright J.C., Yu L., Yang M., Dienstmann R., Guinney J., Beltrao P., Brazma A., Pardo M., Stegle O., Adams D.J., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.
Genomic determinants of protein abundance variation in colorectal cancer cells.
Cell Rep. 20:2201-2214(2017)

Cross-references
Cell line databases/resources CCLE; GEO_LARGE_INTESTINE
ColonAtlas; GEO
Cosmic-CLP; 2164691
Ontologies BTO; BTO:0002892
MCCL; MCC:0000162
Gene expression databases GEO; GSM1448176
Other Wikidata; Q54835723
Polymorphism and mutation databases Cosmic; 738930
Cosmic; 889529
Cosmic; 1131685
Cosmic; 1479567
Cosmic; 1708407
Proteomic databases PRIDE; PXD005235