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Cellosaurus GLC-4 (CVCL_0279)

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Cell line name GLC-4
Synonyms GLC 4; GLC4
Accession CVCL_0279
Resource Identification Initiative To cite this cell line use: GLC-4 (RRID:CVCL_0279)
Comments Doubling time: 26 hours (PubMed=3028613); 16.9 hours (PubMed=8980384).
Omics: Array-based CGH.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4997 (GLC-4/ADR)CVCL_Y299 (GLC-4/AM3x)CVCL_4998 (GLC-4/CDDP)
CVCL_Y297 (GLC-4/CDDP11)CVCL_Y298 (GLC-4/CDDP3)CVCL_4999 (GLC-4/MIT60x)
CVCL_Y301 (GLC-4/VM20x)CVCL_C5RI (GLC4/Sb30)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=3028613
Zijlstra J.G., de Vries E.G.E., Mulder N.H.
Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line.
Cancer Res. 47:1780-1784(1987)

PubMed=3040227
Meijer C., Mulder N.H., Timmer-Bosscha H., Zijlstra J.G., de Vries E.G.E.
Role of free radicals in an adriamycin-resistant human small cell lung cancer cell line.
Cancer Res. 47:4613-4617(1987)

PubMed=1657425; DOI=10.1007/BF00685823
de Jong S., Zijlstra J.G., Mulder N.H., de Vries E.G.E.
Lack of cross-resistance to fostriecin in a human small-cell lung carcinoma cell line showing topoisomerase II-related drug resistance.
Cancer Chemother. Pharmacol. 28:461-464(1991)

PubMed=1320893; DOI=10.1159/000163712
Verbeeck M.A.E., Elands J.P.M., de Leij L.F.M.H., Buys C.H.C.M., Carney D.N., Bepler G., Roebroek A.J.M., van de Ven W.J.M., Burbach J.P.H.
Expression of the vasopressin and gastrin-releasing peptide genes in small cell lung carcinoma cell lines.
Pathobiology 60:136-142(1992)

PubMed=8980384; DOI=10.1038/bjc.1996.647
Withoff S., de Vries E.G.E., Keith W.N., Nienhuis E.F., van der Graaf W.T.A., Uges D.R.A., Mulder N.H.
Differential expression of DNA topoisomerase II alpha and -beta in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4.
Br. J. Cancer 74:1869-1876(1996)

PubMed=9559344; DOI=10.1002/(SICI)1098-2264(199804)21:4<326::AID-GCC6>3.0.CO;2-0
Mulligan L.M., Timmer T., Ivanchuk S.M., Campling B.G., Young L.C., Rabbitts P.H., Sundaresan V., Hofstra R.M.W., Eng C.
Investigation of the genes for RET and its ligand complex, GDNF/GFR alpha-I, in small cell lung carcinoma.
Genes Chromosomes Cancer 21:326-332(1998)

PubMed=10025956; DOI=10.1016/s0014-5793(98)01716-5
Vernhet L., Courtois A., Allain N., Payen L., Anger J.-P., Guillouzo A., Fardel O.
Overexpression of the multidrug resistance-associated protein (MRP1) in human heavy metal-selected tumor cells.
FEBS Lett. 443:321-325(1999)

PubMed=10408787; DOI=10.1097/00019606-199903000-00002
Hayes V.M., Bleeker W., Verlind E., Timmer T., Karrenbeld A., Plukker J.T., Marx M.P., Hofstra R.M.W., Buys C.H.C.M.
Comprehensive TP53-denaturing gradient gel electrophoresis mutation detection assay also applicable to archival paraffin-embedded tissue.
Diagn. Mol. Pathol. 8:2-10(1999)

PubMed=10709110; DOI=10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O
McLaughlin P.M.J., Helfrich W., Kok K., Mulder M., Hu S.W., Brinker M.G.L., Ruiters M.H.J., de Leij L.F.M.H., Buys C.H.C.M.
The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines.
Int. J. Cancer 85:871-876(2000)

PubMed=15150577; DOI=10.1038/sj.bjc.6601863
Boonstra R., Timmer-Bosscha H., van Echten-Arends J., van der Kolk D.M., van den Berg A., de Jong B., Tew K.D., Poppema S., de Vries E.G.E.
Mitoxantrone resistance in a small cell lung cancer cell line is associated with ABCA2 upregulation.
Br. J. Cancer 90:2411-2417(2004)

PubMed=20615970; DOI=10.1073/pnas.1008132107
Voortman J., Lee J.-H., Killian J.K., Suuriniemi M., Wang Y.-H., Lucchi M., Smith W.I. Jr., Meltzer P.S., Wang Y.-S., Giaccone G.
Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors.
Proc. Natl. Acad. Sci. U.S.A. 107:13040-13045(2010)

Cross-references
Cell line databases/resources MCCL; MCC:0000170
cancercelllines; CVCL_0279
Anatomy/cell type resources BTO; BTO:0002385
Chemistry resources ChEMBL-Cells; CHEMBL3307807
ChEMBL-Targets; CHEMBL612707
PubChem_Cell_line; CVCL_0279
Encyclopedic resources Wikidata; Q54835912
Gene expression databases GEO; GSM536324
Polymorphism and mutation databases Cosmic; 1429646
Cosmic; 1998274
Cosmic; 2239121
IARC_TP53; 11273
Progenetix; CVCL_0279
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number22