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Cellosaurus GT1-7 (CVCL_0281)

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Cell line name GT1-7
Accession CVCL_0281
Secondary accession CVCL_8221
Resource Identification Initiative To cite this cell line use: GT1-7 (RRID:CVCL_0281)
Comments Characteristics: Exhibits high levels of Gnrh1 expression and secretes GnRH in response to depolarization.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Misspelling: GTI-7; Occasionally.
Derived from sampling site: Brain; hypothalamus; GnRH neurons.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: (C57BL/6J x BALB/cJ) F2 transgenic with rat Gnrh1 promoter-Tg(SV40).
Hierarchy Parent: CVCL_6235 (GT1)
CVCL_RL73 (GT1-7-OX1)
Category Transformed cell line
STR profile Source(s): Millipore

Mouse STR 1-117
Mouse STR 1-219
Mouse STR 2-116
Mouse STR 3-214
Mouse STR 4-220.3,21.3
Mouse STR 5-513,17
Mouse STR 6-417,18
Mouse STR 6-717
Mouse STR 7-126.2
Mouse STR 8-113,16
Mouse STR 11-216,18
Mouse STR 12-116,17
Mouse STR 13-116.2,17
Mouse STR 15-322.3,23.3
Mouse STR 17-215
Mouse STR 18-316,17
Mouse STR 19-212,13
Mouse STR X-125,28

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PubMed=2196069; DOI=10.1016/0896-6273(90)90028-E
Mellon P.L., Windle J.J., Goldsmith P.C., Padula C.A., Roberts J.L., Weiner R.I.
Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis.
Neuron 5:1-10(1990)

PubMed=1714837; DOI=10.1210/endo-129-3-1584
Wetsel W.C., Mellon P.L., Weiner R.I., Negro-Vilar A.
Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons.
Endocrinology 129:1584-1595(1991)

PubMed=18406727; DOI=10.1016/1043-2760(95)00228-6
Wierman M.E., Fang Z.-Q., Kepa J.K.
GnRH gene expression in neuronal cell lines.
Trends Endocrinol. Metab. 7:60-65(1996)

PubMed=10830297; DOI=10.1210/endo.141.6.7494
Maggi R., Pimpinelli F., Molteni L., Milani M., Martini L., Piva F.
Immortalized luteinizing hormone-releasing hormone neurons show a different migratory activity in vitro.
Endocrinology 141:2105-2112(2000)

Cell line collections BCRJ; 0095
Millipore; SCC116
Cell line databases/resources Lonza; 687
TOKU-E; 4052
Ontologies BTO; BTO:0002708
MCCL; MCC:0000172
Other Wikidata; Q54871828
Entry history
Entry creation04-Apr-2012
Last entry update29-Oct-2020
Version number16