ID   HCA7
AC   CVCL_0289
SY   HCA-7; HCA 7
DR   BTO; BTO:0003031
DR   EFO; EFO_0006415
DR   MCCL; MCC:0000179
DR   AddexBio; C0009003/40
DR   ArrayExpress; E-MTAB-2706
DR   BioSample; SAMN03471988
DR   cancercelllines; CVCL_0289
DR   ColonAtlas; HCA7
DR   Cosmic; 876722
DR   Cosmic; 948860
DR   Cosmic; 985995
DR   Cosmic; 995407
DR   Cosmic; 1043813
DR   Cosmic; 1223140
DR   Cosmic; 1312301
DR   Cosmic; 1479629
DR   Cosmic; 1486131
DR   Cosmic; 1805252
DR   Cosmic; 1933017
DR   Cosmic; 2301976
DR   Cosmic; 2760084
DR   ECACC; 06061902
DR   EGA; EGAS00001000610
DR   GEO; GSM741260
DR   GEO; GSM1346872
DR   GEO; GSM1374491
DR   GEO; GSM1374492
DR   GEO; GSM1448125
DR   GEO; GSM3145708
DR   IARC_TP53; 21760
DR   PharmacoDB; HCA7_445_2019
DR   PRIDE; PXD005354
DR   PRIDE; PXD005355
DR   Wikidata; Q54881491
DR   Ximbio; 152451
RX   PubMed=3718830;
RX   PubMed=4016751;
RX   PubMed=8410493;
RX   PubMed=8464898;
RX   PubMed=9294210;
RX   PubMed=10737795;
RX   PubMed=11226274;
RX   PubMed=16418264;
RX   PubMed=18258742;
RX   PubMed=20570890;
RX   PubMed=20606684;
RX   PubMed=24755471;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=25926053;
RX   PubMed=26589293;
RX   PubMed=29101300;
WW   https://www.cellosaurus.org/pawefish/ColonCellLineDescriptions/HCA7.html
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-584.html
CC   Part of: KuDOS 95 cell line panel.
CC   HLA typing: A*01:01,02:01; B*37:01,51:01; C*06:02,14:02 (PubMed=26589293).
CC   Microsatellite instability: Instable (MSI) (PubMed=24755471; PubMed=25926053).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Glu582fs*20 (c.1742_1743insA); Zygosity=Unspecified (PubMed=24755471).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Unspecified (PubMed=24755471).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg479Ter (c.1435C>T); Zygosity=Unspecified (PubMed=24755471).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro301Glnfs*44 (c.898delC); Zygosity=Unspecified (PubMed=16418264; PubMed=24755471).
CC   Omics: Deep proteome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Discontinued: Ximbio; 152451; probable.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): AddexBio; ECACC; PubMed=25877200; PubMed=25926053
ST   Amelogenin: X
ST   CSF1PO: 11,14
ST   D13S317: 9
ST   D16S539: 10,11 (AddexBio; ECACC; PubMed=25926053)
ST   D16S539: 11 (PubMed=25877200)
ST   D18S51: 19
ST   D21S11: 26,28.2 (PubMed=25877200)
ST   D21S11: 26,28.2,29.2 (PubMed=25926053)
ST   D3S1358: 15,19
ST   D5S818: 8,12 (ECACC; PubMed=25877200)
ST   D5S818: 9,11,12 (PubMed=25926053)
ST   D5S818: 9,12 (AddexBio)
ST   D7S820: 11,12
ST   D8S1179: 12,14
ST   FGA: 18.2,22
ST   Penta D: 9
ST   Penta E: 12,18
ST   TH01: 6,7
ST   TPOX: 8,10
ST   vWA: 14,16
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 35
//
RX   PubMed=3718830; DOI=10.1038/bjc.1986.132;
RA   Kirkland S.C., Bailey I.G.;
RT   "Establishment and characterisation of six human colorectal
RT   adenocarcinoma cell lines.";
RL   Br. J. Cancer 53:779-785(1986).
//
RX   PubMed=4016751;
RA   Kirkland S.C.;
RT   "Dome formation by a human colonic adenocarcinoma cell line (HCA-7).";
RL   Cancer Res. 45:3790-3795(1985).
//
RX   PubMed=8410493; DOI=10.1002/path.1711700407;
RA   Marsh K.A., Stamp G.W.H., Kirkland S.C.;
RT   "Isolation and characterization of multiple cell types from a single
RT   human colonic carcinoma: tumourigenicity of these cell types in a
RT   xenograft system.";
RL   J. Pathol. 170:441-450(1993).
//
RX   PubMed=8464898; DOI=10.1073/pnas.90.7.2842;
RA   Browning M.J., Krausa P., Rowan A.J., Bicknell D.C., Bodmer J.G.,
RA   Bodmer W.F.;
RT   "Tissue typing the HLA-A locus from genomic DNA by sequence-specific
RT   PCR: comparison of HLA genotype and surface expression on colorectal
RT   tumor cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993).
//
RX   PubMed=9294210; DOI=10.1073/pnas.94.19.10330;
RA   Ilyas M., Tomlinson I.P.M., Rowan A.J., Pignatelli M., Bodmer W.F.;
RT   "Beta-catenin mutations in cell lines established from human
RT   colorectal cancers.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997).
//
RX   PubMed=10737795; DOI=10.1073/pnas.97.7.3352;
RA   Rowan A.J., Lamlum H., Ilyas M., Wheeler J., Straub J.,
RA   Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.;
RT   "APC mutations in sporadic colorectal tumors: a mutational 'hotspot'
RT   and interdependence of the 'two hits'.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000).
//
RX   PubMed=11226274; DOI=10.1073/pnas.041603298;
RA   Abdel-Rahman W.M., Katsura K., Rens W., Gorman P.A., Sheer D.,
RA   Bicknell D.C., Bodmer W.F., Arends M.J., Wyllie A.H., Edwards P.A.W.;
RT   "Spectral karyotyping suggests additional subsets of colorectal
RT   cancers characterized by pattern of chromosome rearrangement.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:2538-2543(2001).
//
RX   PubMed=16418264; DOI=10.1073/pnas.0510146103;
RA   Liu Y., Bodmer W.F.;
RT   "Analysis of P53 mutations and their expression in 56 colorectal
RT   cancer cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006).
//
RX   PubMed=18258742; DOI=10.1073/pnas.0712176105;
RA   Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.;
RT   "Cell growth, global phosphotyrosine elevation, and c-Met
RT   phosphorylation through Src family kinases in colorectal cancer
RT   cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008).
//
RX   PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192;
RA   Janakiraman M., Vakiani E., Zeng Z.-S., Pratilas C.A., Taylor B.S.,
RA   Chitale D., Halilovic E., Wilson M., Huberman K., Ricarte Filho J.C.M.,
RA   Persaud Y., Levine D.A., Fagin J.A., Jhanwar S.C., Mariadason J.M.,
RA   Lash A., Ladanyi M., Saltz L.B., Heguy A., Paty P.B., Solit D.B.;
RT   "Genomic and biological characterization of exon 4 KRAS mutations in
RT   human cancer.";
RL   Cancer Res. 70:5901-5911(2010).
//
RX   PubMed=20606684; DOI=10.1038/sj.bjc.6605780;
RA   Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.;
RT   "5-fluorouracil response in a large panel of colorectal cancer cell
RT   lines is associated with mismatch repair deficiency.";
RL   Br. J. Cancer 103:340-346(2010).
//
RX   PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013;
RA   Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S.,
RA   Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S.,
RA   O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F.,
RA   Mariadason J.M., Sieber O.M.;
RT   "Colorectal cancer cell lines are representative models of the main
RT   molecular subtypes of primary cancer.";
RL   Cancer Res. 74:3238-3247(2014).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=25926053; DOI=10.1038/ncomms8002;
RA   Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G.,
RA   Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S.,
RA   Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M.,
RA   Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.;
RT   "The molecular landscape of colorectal cancer cell lines unveils
RT   clinically actionable kinase targets.";
RL   Nat. Commun. 6:7002.1-7002.10(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=29101300; DOI=10.15252/msb.20177701;
RA   Frejno M., Zenezini Chiozzi R., Wilhelm M., Koch H., Zheng R.-S.,
RA   Klaeger S., Ruprecht B., Meng C., Kramer K., Jarzab A., Heinzlmeir S.,
RA   Johnstone E., Domingo E., Kerr D., Jesinghaus M., Slotta-Huspenina J.,
RA   Weichert W., Knapp S., Feller S.M., Kuster B.;
RT   "Pharmacoproteomic characterisation of human colon and rectal
RT   cancer.";
RL   Mol. Syst. Biol. 13:951-951(2017).
//