Cellosaurus HEC-1-A (CVCL_0293)

Cell line name HEC-1-A
Synonyms Hec-1-A; HEC-1A; HEC1-A; HEC1A; Hec1A
Accession CVCL_0293
Resource Identification Initiative To cite this cell line use: HEC-1-A (RRID:CVCL_0293)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: MD Anderson Cell Lines Project.
Part of: PI3K genetic alteration cell panel (ATCC TCP-1028).
Doubling time: 27 hours (PubMed=25984343).
Omics: Deep RNAseq analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1274 (HEC-1)
Children:
CVCL_AR90 (HEC-1-A-OZA1)CVCL_AR91 (HEC-1-A-OZA2)CVCL_AR92 (HEC-1-A-OZA3)
CVCL_AR93 (HEC-1-A-OZA4)CVCL_AR94 (HEC-1-A-OZA5)CVCL_AR95 (HEC-1-A-OZA6)
CVCL_0294 (HEC-1-B)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; IdentiCell; JCRB

Markers:
AmelogeninX
CSF1PO10,12 (ATCC; IdentiCell)
10,13,14 (JCRB)
D13S31711,12 (ATCC)
9,11,14 (IdentiCell)
11 (JCRB)
D16S53912,13 (ATCC; JCRB)
12 (IdentiCell)
D21S1130,31
D5S81811,14,15 (ATCC)
11,15 (IdentiCell; JCRB)
D7S8209,11
TH016,7
TPOX8,11 (ATCC; IdentiCell)
8,9,11 (JCRB)
vWA18,19 (ATCC)
18,19,20 (IdentiCell)
19,20,22 (JCRB)
Web pages http://www.identicell.eu/files/Sample-IdentiCell-report.pdf
http://tcpaportal.org/mclp/
Publications

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=7459858
Rousset M., Zweibaum A., Fogh J.
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=12227503; DOI=10.1111/j.1749-0774.2002.tb00103.x
Kurarmoto H., Hamano M., Imai M.
HEC-1 cells.
Hum. Cell 15:81-95(2002)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
Korch C., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; HTB-112
BCRC; 60552
JCRB; JCRB1117
JCRB; NIHS0388 - Discontinued
Cell line databases/resources CCLE; HEC1A_ENDOMETRIUM
CCRID; 3131C0001000700149
IGRhCellID; HEC1A
Ontologies BTO; BTO:0002960
CLO; CLO_0003674
EFO; EFO_0002191
MCCL; MCC:0000183
Biological sample resources BioSample; SAMN03471093
BioSample; SAMN03472456
Gene expression databases GEO; GSM844555
GEO; GSM844556
GEO; GSM887069
GEO; GSM888139
Polymorphism and mutation databases Cosmic; 713474
Cosmic; 713494
Cosmic; 724853
Cosmic; 809130
Cosmic; 846177
Cosmic; 871552
Cosmic; 889115
Cosmic; 1007160
Cosmic; 1066222
Cosmic; 1177620
Cosmic; 1177685
Cosmic; 1576457
Cosmic; 1594188
Cosmic; 1622896
Cosmic; 2030464
Cosmic; 2301550
Cosmic; 2464665