ID   HEC-1-A
AC   CVCL_0293
SY   Hec-1-A; HEC-1A; HEC1-A; HEC1A; Hec1A
DR   BTO; BTO:0002960
DR   CLO; CLO_0003674
DR   EFO; EFO_0002191
DR   MCCL; MCC:0000183
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ATCC; HTB-112
DR   BCRC; 60552
DR   BioSample; SAMN03471093
DR   BioSample; SAMN03472456
DR   BioSample; SAMN10988293
DR   CCLE; HEC1A_ENDOMETRIUM
DR   CCRID; 3101HUMTCHu149
DR   Cell_Model_Passport; SIDM00595
DR   Cosmic; 713474
DR   Cosmic; 713494
DR   Cosmic; 724853
DR   Cosmic; 809130
DR   Cosmic; 846177
DR   Cosmic; 871552
DR   Cosmic; 889115
DR   Cosmic; 1007160
DR   Cosmic; 1066222
DR   Cosmic; 1177620
DR   Cosmic; 1177685
DR   Cosmic; 1576457
DR   Cosmic; 1594188
DR   Cosmic; 1622896
DR   Cosmic; 2030464
DR   Cosmic; 2301550
DR   Cosmic; 2464665
DR   Cosmic; 2646619
DR   DepMap; ACH-000954
DR   GEO; GSM844555
DR   GEO; GSM844556
DR   GEO; GSM887069
DR   GEO; GSM888139
DR   IARC_TP53; 1110
DR   IGRhCellID; HEC1A
DR   JCRB; JCRB1117
DR   JCRB; NIHS0388
DR   LiGeA; CCLE_208
DR   PharmacoDB; HEC1A_524_2019
DR   Progenetix; CVCL_0293
DR   Wikidata; Q54882246
RX   DOI=10.1007/978-4-431-53981-0_1;
RX   PubMed=327080;
RX   PubMed=833871;
RX   PubMed=2436984;
RX   PubMed=3410349;
RX   PubMed=3518877;
RX   PubMed=4678779;
RX   PubMed=7459858;
RX   PubMed=12068308;
RX   PubMed=12227503;
RX   PubMed=12714694;
RX   PubMed=12893190;
RX   PubMed=15053063;
RX   PubMed=15901131;
RX   PubMed=20215515;
RX   PubMed=20218740;
RX   PubMed=22460905;
RX   PubMed=22710073;
RX   PubMed=25485619;
RX   PubMed=25984343;
RX   PubMed=28196595;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31978347;
WW   http://www.identicell.eu/files/Sample-IdentiCell-report.pdf
WW   https://tcpaportal.org/mclp/
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: PI3K genetic alteration cell panel (ATCC TCP-1028).
CC   Population: Japanese.
CC   Doubling time: 31 hours (DOI=10.1007/978-4-431-53981-0_1); 27 hours (PubMed=25984343).
CC   Microsatellite instability: Instable (MSI) (PubMed=12714694; PubMed=31068700).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=12068308; CCLE).
CC   Sequence variation: Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Heterozygous (CCLE).
CC   Sequence variation: Mutation; HGNC; 7329; MSH6; Simple; c.4001+1G>T; Zygosity=Heterozygous; Note=Splice donor mutation (CCLE).
CC   Sequence variation: Mutation; HGNC; 9122; PMS2; Simple; p.Arg802Ter (c.2404C>T); ClinVar=VCV000009237; Zygosity=Heterozygous (CCLE).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (PubMed=15053063; PubMed=15901131; CCLE).
CC   Omics: Array-based CGH.
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: shRNA library screening.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=0%; Native American=1.14%; East Asian, North=91.32%; East Asian, South=6.71%; South Asian=0.34%; European, North=0.49%; European, South=0% (PubMed=30894373).
CC   Discontinued: JCRB; NIHS0388; true.
CC   Derived from sampling site: Uterus; endometrium.
ST   Source(s): ATCC; Genomics_Center_BCF_Technion; IdentiCell; JCRB
ST   Amelogenin: X
ST   CSF1PO: 10,12 (ATCC; Genomics_Center_BCF_Technion; IdentiCell)
ST   CSF1PO: 10,13,14 (JCRB)
ST   D10S1248: 12,14
ST   D12S391: 19
ST   D13S317: 9,11,14 (IdentiCell)
ST   D13S317: 11 (Genomics_Center_BCF_Technion; JCRB)
ST   D13S317: 11,12 (ATCC)
ST   D16S539: 12 (Genomics_Center_BCF_Technion; IdentiCell)
ST   D16S539: 12,13 (ATCC; JCRB)
ST   D18S51: 16,21
ST   D19S433: 13
ST   D1S1656: 18.3,19
ST   D21S11: 30,31
ST   D22S1045: 11,15
ST   D2S1338: 18,19
ST   D2S441: 11,13
ST   D3S1358: 15
ST   D5S818: 11,14,15 (ATCC)
ST   D5S818: 11,15 (Genomics_Center_BCF_Technion; IdentiCell; JCRB)
ST   D7S820: 9,11
ST   D8S1179: 13,14
ST   FGA: 21,22
ST   Penta D: 9,12
ST   Penta E: 11
ST   TH01: 6,7
ST   TPOX: 8,9,11 (JCRB)
ST   TPOX: 8,11 (ATCC; Genomics_Center_BCF_Technion; IdentiCell)
ST   vWA: 18,19 (ATCC; Genomics_Center_BCF_Technion)
ST   vWA: 18,19,20 (IdentiCell)
ST   vWA: 19,20,22 (JCRB)
DI   NCIt; C7359; Endometrial adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_1274 ! HEC-1
SX   Female
AG   71Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 23-09-21; Version: 31
//
RX   DOI=10.1007/978-4-431-53981-0_1;
RA   Kuramoto H., Hamano M., Imai M., Fujisawa T., Kamata Y., Arai T.,
RA   Kawaguchi M.;
RT   "HEC-1 cells: establishment of an in vitro experimental system in
RT   endometrial carcinoma.";
RL   (In) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo (2003).
//
RX   PubMed=327080; DOI=10.1093/jnci/59.1.221;
RA   Fogh J., Fogh J.M., Orfeo T.;
RT   "One hundred and twenty-seven cultured human tumor cell lines
RT   producing tumors in nude mice.";
RL   J. Natl. Cancer Inst. 59:221-226(1977).
//
RX   PubMed=833871; DOI=10.1093/jnci/58.2.209;
RA   Fogh J., Wright W.C., Loveless J.D.;
RT   "Absence of HeLa cell contamination in 169 cell lines derived from
RT   human tumors.";
RL   J. Natl. Cancer Inst. 58:209-214(1977).
//
RX   PubMed=2436984; DOI=10.1016/0090-8258(87)90286-1;
RA   Noumoff J., Haydock S.W., Sachdeva R., Heyner S., Pritchard M.L.;
RT   "Characteristics of cell lines derived from normal and malignant
RT   endometrial tissue.";
RL   Gynecol. Oncol. 27:141-149(1987).
//
RX   PubMed=3410349; DOI=10.1016/0090-8258(88)90297-1;
RA   Noumoff J.S., Simon D., Heyner S., Farber M., Haydock S.W.,
RA   Pritchard M.L.;
RT   "Cytogenetics of an endometrial adenocarcinoma cell line and its
RT   implications.";
RL   Gynecol. Oncol. 31:217-222(1988).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh J.;
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=4678779;
RA   Kuramoto H.;
RT   "Studies of the growth and cytogenetic properties of human endometrial
RT   adenocarcinoma in culture and its development into an established
RT   line.";
RL   Nihon Sanka Fujinka Gakkai Zasshi 19:47-58(1972).
//
RX   PubMed=7459858;
RA   Rousset M., Zweibaum A., Fogh J.;
RT   "Presence of glycogen and growth-related variations in 58 cultured
RT   human tumor cell lines of various tissue origins.";
RL   Cancer Res. 41:1165-1170(1981).
//
RX   PubMed=12068308; DOI=10.1038/nature00766;
RA   Davies H., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S.,
RA   Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N.,
RA   Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J.,
RA   Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S.,
RA   Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.,
RA   Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J.,
RA   Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A.,
RA   Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T.,
RA   Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R.,
RA   Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.;
RT   "Mutations of the BRAF gene in human cancer.";
RL   Nature 417:949-954(2002).
//
RX   PubMed=12227503; DOI=10.1111/j.1749-0774.2002.tb00103.x;
RA   Kurarmoto H., Hamano M., Imai M.;
RT   "HEC-1 cells.";
RL   Hum. Cell 15:81-95(2002).
//
RX   PubMed=12714694; DOI=10.1093/mutage/18.3.277;
RA   Yamada N.A., Castro A., Farber R.A.;
RT   "Variation in the extent of microsatellite instability in human cell
RT   lines with defects in different mismatch repair genes.";
RL   Mutagenesis 18:277-282(2003).
//
RX   PubMed=12893190; DOI=10.1016/s0090-8258(03)00335-4;
RA   Tanaka R., Saito T., Ashihara K., Nishimura M., Mizumoto H., Kudo R.;
RT   "Three-dimensional coculture of endometrial cancer cells and
RT   fibroblasts in human placenta derived collagen sponges and expression
RT   matrix metalloproteinases in these cells.";
RL   Gynecol. Oncol. 90:297-304(2003).
//
RX   PubMed=15053063;
RA   Kamata Y., Watanabe J., Hata H., Hamano M., Kuramoto H.;
RT   "Quantitative study on the correlation between p53 gene mutation and
RT   its expression in endometrial carcinoma cell lines.";
RL   Eur. J. Gynaecol. Oncol. 25:55-60(2004).
//
RX   PubMed=15901131; DOI=10.1016/j.prp.2005.01.002;
RA   Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y.;
RT   "Correlation between DNA alterations and p53 and p16 protein
RT   expression in cancer cell lines.";
RL   Pathol. Res. Pract. 201:109-115(2005).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=20218740; DOI=10.1177/153303461000900207;
RA   Wang Y.-M., Yang D., Cogdell D., Hu L.-M., Xue F.-X., Broaddus R.,
RA   Zhang W.;
RT   "Genomic characterization of gene copy-number aberrations in
RT   endometrial carcinoma cell lines derived from endometrioid-type
RT   endometrial adenocarcinoma.";
RL   Technol. Cancer Res. Treat. 9:179-189(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017;
RA   Korch C., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K.,
RA   Lessey B.A., Jordan V.C., Bradford A.P.;
RT   "DNA profiling analysis of endometrial and ovarian cell lines reveals
RT   misidentification, redundancy and contamination.";
RL   Gynecol. Oncol. 127:241-248(2012).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35;
RA   Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S.,
RA   East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H.,
RA   Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M.,
RA   Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S.,
RA   Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D.,
RA   Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C.,
RA   Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P.,
RA   Golub T.R., Root D.E., Hahn W.C.;
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035-140035(2014).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31978347; DOI=10.1016/j.cell.2019.12.023;
RA   Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III,
RA   Kalocsay M., Jane-Valbuena J., Gelfand E., Schweppe D.K.,
RA   Jedrychowski M., Golji J., Porter D.A., Rejtar T., Wang Y.K.,
RA   Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A.,
RA   Sellers W.R., Gygi S.P.;
RT   "Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
RL   Cell 180:387-402.e16(2020).
//