ID   HIT-T15
AC   CVCL_0301
SY   HIT T15; HIT.T15; HIT T-15; HITT15; HIT clone T15; Hamster Islet Transformed-Tioguanine resistant clone 15; HIT
DR   BTO; BTO:0000627
DR   CLO; CLO_0003758
DR   MCCL; MCC:0000192
DR   ATCC; CRL-1777
DR   IZSLER; BS TCL 188
DR   KCB; KCB 200828YJ
DR   KCLB; 21777
DR   Wikidata; Q54889679
RX   PubMed=3535793;
RX   PubMed=6270673;
RX   PubMed=8697299;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-502.html
CC   Characteristics: Secretes insulin. Maximal stimulation is obtained with glucose, arginine and leucine (PubMed=3535793).
CC   Doubling time: 33-34 hours (PubMed=6270673).
CC   Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
CC   Transformant: ChEBI; CHEBI:23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from sampling site: Pancreas; islets of Langerhans.
OX   NCBI_TaxID=10036; ! Mesocricetus auratus
SX   Sex unspecified
AG   Age unspecified
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 20-05-21; Version: 15
//
RX   PubMed=3535793; DOI=10.1016/0006-291X(86)90776-X;
RA   Lambert D.G., Hughes K., Atkins T.W.;
RT   "Insulin release from a cloned hamster B-cell line (HIT-T15). The
RT   effects of glucose, amino acids, sulphonylureas and colchicine.";
RL   Biochem. Biophys. Res. Commun. 140:616-625(1986).
//
RX   PubMed=6270673; DOI=10.1073/pnas.78.7.4339;
RA   Santerre R.F., Cook R.A., Crisel R.M., Sharp J.D., Schmidt R.J.,
RA   Williams D.C., Wilson C.P.;
RT   "Insulin synthesis in a clonal cell line of simian virus
RT   40-transformed hamster pancreatic beta cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 78:4339-4343(1981).
//
RX   PubMed=8697299;
RA   Poitout V., Olson L.K., Robertson R.P.;
RT   "Insulin-secreting cell lines: classification, characteristics and
RT   potential applications.";
RL   Diabetes Metab. 22:7-14(1996).
//