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Cellosaurus HK-2 [Human kidney] (CVCL_0302)

[Text version]

Cell line name HK-2 [Human kidney]
Synonyms Hk-2; HK2; Human Kidney-2
Accession CVCL_0302
Resource Identification Initiative To cite this cell line use: HK-2 [Human kidney] (RRID:CVCL_0302)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16) [E6/E7 (pLXSN)].
Omics: SNP array analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.63
Native American0
East Asian, North3.68
East Asian, South0
South Asian0
European, North62.77
European, South29.92
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UC05 (HK-2-KIM-1)CVCL_WZ51 (HKC)
Sex of cell Male
Age at sampling Adult
Category Transformed cell line
STR profile Source(s): AddexBio; ATCC; CCRID; KCLB

Markers:
AmelogeninX (CCRID)
X,Y (AddexBio; ATCC; KCLB)
CSF1PO13
D2S133817,25
D3S135816,17
D5S81812
D7S82010,11
D8S117910,14
D13S3179
D16S53911,12
D18S5112
D19S43315,15.2
D21S1128,30
FGA20,22
TH019
TPOX8,9
vWA17,18

Run an STR similarity search on this cell line
Web pages http://www.cellresource.cn/fdetail.aspx?id=159
http://www.cellresource.cn/fdetail.aspx?id=904
Publications

PubMed=8127021; DOI=10.1038/ki.1994.6
Ryan M.J., Johnson G., Kirk J., Fuerstenberg S.M., Zager R.A., Torok-Storb B.
HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney.
Kidney Int. 45:48-57(1994)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20555413; DOI=10.1139/y10-023
Gunness P., Aleksa K., Kosuge K., Ito S., Koren G.
Comparison of the novel HK-2 human renal proximal tubular cell line with the standard LLC-PK1 cell line in studying drug-induced nephrotoxicity.
Can. J. Physiol. Pharmacol. 88:448-455(2010)

PubMed=22949125; DOI=10.1002/ijc.27822
Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.
Loss of PBRM1 expression is associated with renal cell carcinoma progression.
Int. J. Cancer 132:E11-E17(2013)

PubMed=28489074; DOI=10.1038/ncomms15165
Sinha R., Winer A.G., Chevinsky M., Jakubowski C., Chen Y.-B., Dong Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C., Hsieh J.J., Hakimi A.A.
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.
Nat. Commun. 8:15165-15165(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections AddexBio; T0011004/4929
ATCC; CRL-2190
BCRC; 60097
CCTCC; GDC0152
KCB; KCB 200815YJ
KCLB; 22190
Cell line databases/resources CCLE; HK2_KIDNEY
CCRID; 3111C0001CCC000159
CCRID; 3142C0001000000136
DepMap; ACH-001087
Lonza; 769
Ontologies BTO; BTO:0003575
CLO; CLO_0003771
MCCL; MCC:0000193
Biological sample resources BioSample; SAMN03472562
Chemistry resources PharmacoDB; HK2_545_2019
Gene expression databases GEO; GSM827261
Other Wikidata; Q54889732
Polymorphism and mutation databases Cosmic; 2520628
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number19