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Cellosaurus HK-2 [Human kidney] (CVCL_0302)

[Text version]

Cell line name HK-2 [Human kidney]
Synonyms Hk-2; HK2; Human Kidney-2
Accession CVCL_0302
Resource Identification Initiative To cite this cell line use: HK-2 [Human kidney] (RRID:CVCL_0302)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16) [E6/E7].
Omics: SNP array analysis.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UC05 (HK-2-KIM-1)
Sex of cell Male
Age at sampling Adult
Category Transformed cell line
STR profile Source(s): AddexBio; ATCC; KCLB

Markers:
AmelogeninX,Y
CSF1PO13
D3S135816,17
D5S81812
D7S82010,11
D13S3179
D16S53911,12
FGA20,22
TH019
TPOX8,9
vWA17,18
Publications

PubMed=8127021; DOI=10.1038/ki.1994.6
Ryan M.J., Johnson G., Kirk J., Fuerstenberg S.M., Zager R.A., Torok-Storb B.
HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney.
Kidney Int. 45:48-57(1994)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20555413; DOI=10.1139/y10-023
Gunness P., Aleksa K., Kosuge K., Ito S., Koren G.
Comparison of the novel HK-2 human renal proximal tubular cell line with the standard LLC-PK1 cell line in studying drug-induced nephrotoxicity.
Can. J. Physiol. Pharmacol. 88:448-455(2010)

PubMed=28489074; DOI=10.1038/ncomms15165
Sinha R., Winer A.G., Chevinsky M., Jakubowski C., Chen Y.-B., Dong Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C., Hsieh J.J., Hakimi A.A.
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.
Nat. Commun. 8:15165-15165(2017)

Cross-references
Cell line collections AddexBio; T0011004/4929
ATCC; CRL-2190
BCRC; 60097
KCB; KCB 200815YJ
KCLB; 22190
Cell line databases/resources CCLE; HK2_KIDNEY
CCRID; 3111C0001CCC000159
CCRID; 3142C0001000000136
Lonza; 769
Ontologies BTO; BTO:0003575
CLO; CLO_0003771
MCCL; MCC:0000193
Biological sample resources BioSample; SAMN03472562
Gene expression databases GEO; GSM827261
Other Wikidata; Q54889732
Polymorphism and mutation databases Cosmic; 2520628