ID   HK-2 [Human kidney]
AC   CVCL_0302
SY   Hk-2; HK2; Human Kidney-2
DR   BTO; BTO:0003575
DR   CLO; CLO_0003771
DR   MCCL; MCC:0000193
DR   AddexBio; T0011004/4929
DR   ATCC; CRL-2190
DR   BCRC; 60097
DR   BioSample; SAMN03472562
DR   CCLE; HK2_KIDNEY
DR   CCRID; 3111C0001CCC000159
DR   CCRID; 3142C0001000000136
DR   CCTCC; GDC0152
DR   Cosmic; 2520628
DR   DepMap; ACH-001087
DR   ENCODE; ENCBS188NWH
DR   GEO; GSM827261
DR   KCB; KCB 200815YJ
DR   KCLB; 22190
DR   Lonza; 769
DR   PharmacoDB; HK2_545_2019
DR   Wikidata; Q54889732
RX   PubMed=8127021;
RX   PubMed=20215515;
RX   PubMed=20555413;
RX   PubMed=22949125;
RX   PubMed=28489074;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   http://www.cellresource.cn/fdetail.aspx?id=159
WW   http://www.cellresource.cn/fdetail.aspx?id=904
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16) [E6/E7 (pLXSN)].
CC   Omics: SNP array analysis.
CC   Genome ancestry: African=3.63%; Native American=0%; East Asian, North=3.68%; East Asian, South=0%; South Asian=0%; European, North=62.77%; European, South=29.92% (PubMed=30894373).
ST   Source(s): AddexBio; ATCC; CCRID; KCLB
ST   Amelogenin: X (CCRID)
ST   Amelogenin: X,Y (AddexBio; ATCC; KCLB)
ST   CSF1PO: 13
ST   D13S317: 9
ST   D16S539: 11,12
ST   D18S51: 12
ST   D19S433: 15,15.2
ST   D21S11: 28,30
ST   D2S1338: 17,25
ST   D3S1358: 16,17
ST   D5S818: 12
ST   D7S820: 10,11
ST   D8S1179: 10,14
ST   FGA: 20,22
ST   TH01: 9
ST   TPOX: 8,9
ST   vWA: 17,18
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   Adult
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 19-12-19; Version: 20
//
RX   PubMed=8127021; DOI=10.1038/ki.1994.6;
RA   Ryan M.J., Johnson G., Kirk J., Fuerstenberg S.M., Zager R.A.,
RA   Torok-Storb B.;
RT   "HK-2: an immortalized proximal tubule epithelial cell line from
RT   normal adult human kidney.";
RL   Kidney Int. 45:48-57(1994).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=20555413; DOI=10.1139/y10-023;
RA   Gunness P., Aleksa K., Kosuge K., Ito S., Koren G.;
RT   "Comparison of the novel HK-2 human renal proximal tubular cell line
RT   with the standard LLC-PK1 cell line in studying drug-induced
RT   nephrotoxicity.";
RL   Can. J. Physiol. Pharmacol. 88:448-455(2010).
//
RX   PubMed=22949125; DOI=10.1002/ijc.27822;
RA   Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.;
RT   "Loss of PBRM1 expression is associated with renal cell carcinoma
RT   progression.";
RL   Int. J. Cancer 132:E11-E17(2013).
//
RX   PubMed=28489074; DOI=10.1038/ncomms15165;
RA   Sinha R., Winer A.G., Chevinsky M., Jakubowski C., Chen Y.-B., Dong Y.,
RA   Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C.,
RA   Hsieh J.J., Hakimi A.A.;
RT   "Analysis of renal cancer cell lines from two major resources enables
RT   genomics-guided cell line selection.";
RL   Nat. Commun. 8:15165-15165(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//