ID   HPAF-II
AC   CVCL_0313
SY   HPAF II; HPAFII; HPAF-2; HPAF2; HPAF/CD18; CD18/HPAF; HPAF-II/CD18; CD-18; CD18; CD 18
DR   BTO; BTO:0003266
DR   CLO; CLO_0003816
DR   EFO; EFO_0002198
DR   MCCL; MCC:0000206
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-1997
DR   BioSample; SAMN03471950
DR   BioSample; SAMN10987875
DR   CCLE; HPAFII_PANCREAS
DR   CCRID; 3101HUMSCSP5011
DR   Cell_Model_Passport; SIDM00669
DR   CGH-DB; 165-1
DR   CGH-DB; 9274-4
DR   ChEMBL-Cells; CHEMBL3308744
DR   ChEMBL-Targets; CHEMBL1075467
DR   Cosmic; 710858
DR   Cosmic; 724869
DR   Cosmic; 868241
DR   Cosmic; 913304
DR   Cosmic; 922247
DR   Cosmic; 1108343
DR   Cosmic; 1299299
DR   Cosmic; 1320467
DR   Cosmic; 1571777
DR   Cosmic; 2046534
DR   Cosmic; 2434099
DR   Cosmic-CLP; 724869
DR   DepMap; ACH-000094
DR   GDSC; 724869
DR   GEO; GSM206510
DR   GEO; GSM385517
DR   GEO; GSM385528
DR   GEO; GSM621899
DR   GEO; GSM784696
DR   GEO; GSM827289
DR   GEO; GSM887090
DR   GEO; GSM888161
DR   GEO; GSM1024402
DR   GEO; GSM1374546
DR   GEO; GSM1374547
DR   GEO; GSM1669893
DR   IARC_TP53; 944
DR   IGRhCellID; HPAFII
DR   IZSLER; BS TCL 170
DR   LiGeA; CCLE_028
DR   LINCS_LDP; LCL-1736
DR   MetaboLights; MTBLS812
DR   PharmacoDB; HPAFII_565_2019
DR   PRIDE; PXD003198
DR   Progenetix; CVCL_0313
DR   TOKU-E; 4028
DR   Wikidata; Q54890231
RX   DOI=10.4172/jpb.1000057;
RX   PubMed=1764370;
RX   PubMed=2734279;
RX   PubMed=11787853;
RX   PubMed=12068308;
RX   PubMed=12692724;
RX   PubMed=15126341;
RX   PubMed=15367885;
RX   PubMed=15367897;
RX   PubMed=18380791;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=20418756;
RX   PubMed=22460905;
RX   PubMed=22585861;
RX   PubMed=25485619;
RX   PubMed=25984343;
RX   PubMed=26216984;
RX   PubMed=27259358;
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=29444439;
RX   PubMed=30894373;
RX   PubMed=31037374;
RX   PubMed=31068700;
WW   http://dpsc.ccbr.utoronto.ca/cancer/get_cellline.pl?cellline=HPAF-II
WW   https://tcpaportal.org/mclp/
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Part of: KuDOS 95 cell line panel.
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: NCI RAS program mutant KRAS cell line panel.
CC   Doubling time: 26 hours (PubMed=2734279); 70 hours (PubMed=25984343).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg29_Ala34del (c.85_102del18); Zygosity=Heterozygous (PubMed=11787853; PubMed=15367885; CCLE; Cosmic-CLP).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=11787853; PubMed=12068308; PubMed=15367885; CCLE; Cosmic-CLP).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro151Ser (c.451C>T); ClinVar=VCV000012370; Zygosity=Homozygous (PubMed=11787853; PubMed=15367885; CCLE; Cosmic-CLP).
CC   Omics: Array-based CGH.
CC   Omics: Deep exome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Metabolome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Proteome analysis by 2D-DE/MS.
CC   Omics: shRNA library screening.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=0.96%; Native American=0.23%; East Asian, North=0.7%; East Asian, South=0%; South Asian=0%; European, North=64.61%; European, South=33.49% (PubMed=30894373).
CC   Caution: Could not find proof that the CD18 subline of HPAF is really HPAF-II but many indirect evidences points in this direction. If someone read this comment and can help us, please do.
CC   Caution: TP53 mutation indicated incorrectly as being at c.452C>T in PubMed=1764370.
CC   Misspelling: HPAF11; In PubMed=25984343.
CC   Misspelling: Hapaf-II; Occasionally.
CC   Derived from metastatic site: Ascites.
ST   Source(s): AddexBio; ATCC; Cosmic-CLP; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 12
ST   D16S539: 11,13
ST   D18S51: 13
ST   D21S11: 30,31
ST   D3S1358: 14,18
ST   D5S818: 11,13
ST   D7S820: 10,13
ST   D8S1179: 11,12
ST   F13A01: 5,17
ST   F13B: 8,10
ST   FESFPS: 11,12
ST   FGA: 21,24
ST   LPL: 10
ST   Penta D: 9,13
ST   Penta E: 10,13
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_B284 ! HPAF
SX   Male
AG   44Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 23-09-21; Version: 34
//
RX   DOI=10.4172/jpb.1000057;
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RT   "Abnormalities of the p53 tumour suppressor gene in human pancreatic
RT   cancer.";
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//
RX   PubMed=2734279; DOI=10.1097/00006676-198906000-00013;
RA   Kim Y.W., Kern H.F., Mullins T.D., Koriwchak M.J., Metzgar R.S.;
RT   "Characterization of clones of a human pancreatic adenocarcinoma cell
RT   line representing different stages of differentiation.";
RL   Pancreas 4:353-362(1989).
//
RX   PubMed=11787853; DOI=10.1007/s004280100474;
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RT   p53, p16 and DPC4/Smad4.";
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RX   PubMed=15126341; DOI=10.1158/0008-5472.CAN-03-3159;
RA   Heidenblad M., Schoenmakers E.F.P.M., Jonson T., Gorunova L.,
RA   Veltman J.A., van Kessel A.G., Hoglund M.;
RT   "Genome-wide array-based comparative genomic hybridization reveals
RT   multiple amplification targets and novel homozygous deletions in
RT   pancreatic carcinoma cell lines.";
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//
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RA   Hirohashi S.;
RT   "Orthotopic transplantation models of pancreatic adenocarcinoma
RT   derived from cell lines and primary tumors and displaying varying
RT   metastatic activity.";
RL   Pancreas 29:193-203(2004).
//
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RA   Rajasekaran S.A., Gopal J., Espineda C., Ryazantsev S.,
RA   Schneeberger E.E., Rajasekaran A.K.;
RT   "HPAF-II, a cell culture model to study pancreatic epithelial cell
RT   structure and function.";
RL   Pancreas 29:E77-E83(2004).
//
RX   PubMed=18380791; DOI=10.1111/j.1349-7006.2008.00779.x;
RA   Suzuki A., Shibata T., Shimada Y., Murakami Y., Horii A.,
RA   Shiratori K., Hirohashi S., Inazawa J., Imoto I.;
RT   "Identification of SMURF1 as a possible target for 7q21.3-22.1
RT   amplification detected in a pancreatic cancer cell line by in-house
RT   array-based comparative genomic hybridization.";
RL   Cancer Sci. 99:986-994(2008).
//
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RA   Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
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RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
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RA   Deer E.L., Gonzalez-Hernandez J., Coursen J.D., Shea J.E., Ngatia J.,
RA   Scaife C.L., Firpo M.A., Mulvihill S.J.;
RT   "Phenotype and genotype of pancreatic cancer cell lines.";
RL   Pancreas 39:425-435(2010).
//
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RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
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RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
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RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
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RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
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RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224;
RA   Marcotte R., Brown K.R., Suarez Saiz F.J., Sayad A., Karamboulas K.,
RA   Krzyzanowski P.M., Sircoulomb F., Medrano M., Fedyshyn Y., Koh J.L.Y.,
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RT   "Essential gene profiles in breast, pancreatic, and ovarian cancer
RT   cells.";
RL   Cancer Discov. 2:172-189(2012).
//
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RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
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RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35;
RA   Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S.,
RA   East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H.,
RA   Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M.,
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RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035-140035(2014).
//
RX   PubMed=26216984; DOI=10.1073/pnas.1501605112;
RA   Daemen A., Peterson D., Sahu N., McCord R., Du X.-N., Liu B.,
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RT   into subtypes with distinct sensitivities to metabolic inhibitors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015).
//
RX   PubMed=27259358; DOI=10.1074/mcp.M116.058313;
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RT   global phosphotyrosine profiling.";
RL   Mol. Cell. Proteomics 15:2671-2685(2016).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
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//
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RL   Cell Rep. 22:1889-1902(2018).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
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RL   Cancer Res. 79:1263-1273(2019).
//
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RA   Wittel U.A., Kammerer B.;
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RT   liquid-chromatography coupling to ion mobility mass spectrometry.";
RL   Anal. Bioanal. Chem. 411:6319-6328(2019).
//
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RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
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RL   Nature 569:503-508(2019).
//