Cellosaurus HT-1080 (CVCL_0317)

Cell line name HT-1080
Synonyms Ht-1080; HT 1080; HT1080; HT 1080.T
Accession CVCL_0317
Resource Identification Initiative To cite this cell line use: HT-1080 (RRID:CVCL_0317)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: ENCODE project common cell types; tier 3.
Part of: MD Anderson Cell Lines Project.
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Doubling time: 26 hours (PubMed=4132053); ~30 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: Heterozygous for IDH1 p.Arg132Cys (PubMed=26368816).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: HT1180; Occasionally.
Disease Fibrosarcoma (NCIt: C3043)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_1D50 (2C4 [Human fibrosarcoma]); CVCL_0115 (2fTGH); CVCL_8870 (FLYA13); CVCL_8871 (FLYRD18); CVCL_3715 (HP); CVCL_DF43 (HT-1080 NucLight Green); CVCL_DF44 (HT-1080 NucLight Red); CVCL_V355 (HT-1080 Tet-Off); CVCL_JG56 (HT-1080/CMV-Luc); CVCL_AR54 (HT-STAR); CVCL_AX37 (HT1080 FUS-DDIT3-EGFP); CVCL_L898 (HT1080-luc2); CVCL_5I99 (HT1080-Red-FLuc); CVCL_6C48 (HT1080/DR4); CVCL_D683 (HTD114); CVCL_3318 (HX); CVCL_V634 (JH-2/TPA); CVCL_8437 (PEAZ-1)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ATCC; CLS; Cosmic-CLP; DSMZ; ECACC; JCRB; KCLB; PubMed=11416159; PubMed=17254797; PubMed=25877200; RCB

Markers:
AmelogeninX,Y
CSF1PO12 (ATCC; CLS; Cosmic-CLP; DSMZ; ECACC; JCRB; KCLB; PubMed=25877200; RCB)
11 (PubMed=17254797)
D13S31712,14
D16S5399,12
D18S5112,18
D21S1128,30
D3S135816
D5S81811,13
D7S8209,10
D8S117913,14
FGA22,25
Penta D9,12
Penta E5,15
TH016
TPOX8
vWA14,19
Web pages https://en.wikipedia.org/wiki/HT1080
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-124.html
http://tcpaportal.org/mclp/
Publications

PubMed=4132053; DOI=10.1002/1097-0142(197404)33:4<1027::AID-CNCR2820330419>3.0.CO;2-Z
Rasheed S., Nelson-Rees W.A., Toth E.M., Arnstein P., Gardner M.B.
Characterization of a newly derived human sarcoma cell line (HT-1080).
Cancer 33:1027-1033(1974)

PubMed=6652615; DOI=10.1016/0165-4608(83)90092-4
Chen T.-R., Hay R.J., Macy M.L.
Intercellular karyotypic similarity in near-diploid cell lines of human tumor origins.
Cancer Genet. Cytogenet. 10:351-362(1983)

PubMed=3558490; DOI=10.1002/jcp.1041300303
Gupta R.S., Dudani A.K.
Species-specific differences in the toxicity of rhodamine 123 towards cultured mammalian cells.
J. Cell. Physiol. 130:321-327(1987)

PubMed=3413074; DOI=10.1073/pnas.85.16.604
Pereira-Smith O.M., Smith J.R.
Genetic analysis of indefinite division in human cells: identification of four complementation groups.
Proc. Natl. Acad. Sci. U.S.A. 85:6042-6046(1988)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Azari S., Ahmadi N., Tehrani M.J., Shokri F.
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24726063; DOI=10.1186/1756-9966-33-33
Koelsche C., Renner M., Hartmann W., Brandt R., Lehner B., Waldburger N., Alldinger I., Schmitt T., Egerer G., Penzel R., Wardelmann E., Schirmacher P., von Deimling A., Mechtersheimer G.
TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities.
J. Exp. Clin. Cancer Res. 33:33-33(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=26368816; DOI=10.1371/journal.pone.0133813
Li L., Paz A.C., Wilky B.A., Johnson B., Galoian K., Rosenberg A., Hu G., Tinoco G., Bodamer O., Trent J.C.
Treatment with a small molecule mutant IDH1 inhibitor suppresses tumorigenic activity and decreases production of the oncometabolite 2-hydroxyglutarate in human chondrosarcoma cells.
PLoS ONE 10:E0133813-E0133813(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; CCL-121
ATCC; CRL-7951 - Discontinued
BCRC; 60037
BCRJ; 0110
CLS; 300216/p517_HT-1080
DSMZ; ACC-315
ECACC; 85111505
ICLC; HTL98016
IFO; IFO50354
IZSLER; BS TCL 27
JCRB; JCRB9113
KCB; KCB 2013029YJ
KCLB; 10121
NCBI_Iran; C437
RCB; RCB1956 - Discontinued
Cell line databases/resources CLDB; cl1735
CLDB; cl1736
CLDB; cl1737
CLDB; cl1738
CLDB; cl1740
CLDB; cl1741
CLDB; cl1742
CLDB; cl4913
CCLE; HT1080_SOFT_TISSUE
CCRID; 3111C0001CCC000070
CCRID; 3142C0001000000116
Cosmic-CLP; 907064
GDSC; 907064
IGRhCellID; HT1080
LINCS_LDP; LCL-1435
Lonza; 744
TOKU-E; 1963
Ontologies BTO; BTO:0001282
CLO; CLO_0004266
CLO; CLO_0004276
EFO; EFO_0002059
MCCL; MCC:0000210
Biological sample resources BioSample; SAMN01821563
BioSample; SAMN01821634
BioSample; SAMN01821685
BioSample; SAMN01821731
BioSample; SAMN03471913
ENCODE; ENCBS039VHD
ENCODE; ENCBS225AAA
ENCODE; ENCBS512AAA
ENCODE; ENCBS513AAA
ENCODE; ENCBS617SGR
ENCODE; ENCBS688VJF
ENCODE; ENCBS798NML
ENCODE; ENCBS816VMN
ENCODE; ENCBS937RAY
Chemistry resources ChEMBL-Cells; CHEMBL3308396
ChEMBL-Targets; CHEMBL614580
Gene expression databases GEO; GSM185089
GEO; GSM185090
GEO; GSM256074
GEO; GSM256075
GEO; GSM256076
GEO; GSM256077
GEO; GSM256078
GEO; GSM256079
GEO; GSM256080
GEO; GSM256081
GEO; GSM256082
GEO; GSM256083
GEO; GSM256084
GEO; GSM256085
GEO; GSM256086
GEO; GSM256087
GEO; GSM256088
GEO; GSM256089
GEO; GSM256090
GEO; GSM256091
GEO; GSM256092
GEO; GSM256093
GEO; GSM256094
GEO; GSM256095
GEO; GSM256096
GEO; GSM256097
GEO; GSM256098
GEO; GSM256099
GEO; GSM256100
GEO; GSM256101
GEO; GSM256102
GEO; GSM256103
GEO; GSM256104
GEO; GSM256105
GEO; GSM256106
GEO; GSM256107
GEO; GSM256108
GEO; GSM256109
GEO; GSM256110
GEO; GSM256111
GEO; GSM256112
GEO; GSM256113
GEO; GSM256114
GEO; GSM827307
GEO; GSM887136
GEO; GSM888207
GEO; GSM1669908
GEO; GSM1676302
GEO; GSM1701637
Other Wikidata; Q5636047
Polymorphism and mutation databases Cosmic; 716177
Cosmic; 716188
Cosmic; 724819
Cosmic; 907064
Cosmic; 912000
Cosmic; 1045409
Cosmic; 1067221
Cosmic; 1933190
Cosmic; 2009505
Cosmic; 2301553
Cosmic; 2307731