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Cellosaurus HT-1080 (CVCL_0317)

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Cell line name HT-1080
Synonyms Ht-1080; HT 1080; HT1080; HT 1080.T
Accession CVCL_0317
Resource Identification Initiative To cite this cell line use: HT-1080 (RRID:CVCL_0317)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ENCODE project common cell types; tier 3.
Part of: MD Anderson Cell Lines Project.
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: Caucasian.
Doubling time: 26 hours (PubMed=4132053); ~30 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: HT1180; Occasionally.
Derived from sampling site: Acetabulum; connective tissue.
Sequence variations Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (ATCC).
Mutation; HGNC; 5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (PubMed=26368816).
Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (PubMed=12068308; ATCC; Cosmic-CLP; DepMap).
HLA typing Source: CLS
Class I
Class II
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.35
East Asian, North1.36
East Asian, South0.29
South Asian0
European, North68.21
European, South28.94
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1D50 (2C4 [Human fibrosarcoma])CVCL_0115 (2fTGH)CVCL_8870 (FLYA13)
CVCL_8871 (FLYRD18)CVCL_RW47 (HL116)CVCL_3715 (HP)
CVCL_XG90 (HT-1080 JH-1/FIX)CVCL_DF43 (HT-1080 NucLight Green)CVCL_DF44 (HT-1080 NucLight Red)
CVCL_V355 (HT-1080 Tet-Off)CVCL_UZ99 (HT-1080-Luc2)CVCL_VI98 (HT-1080/Arabidopsis hybrid chr15)
CVCL_XZ54 (HT1080 human CD137)CVCL_XZ55 (HT1080 human CD27)CVCL_XZ56 (HT1080 human CD40)
CVCL_UE32 (HT1080 human GITR)CVCL_UE31 (HT1080 human OX40)CVCL_RA09 (HT1080-eGFP-Puro)
CVCL_RA10 (HT1080-Fluc-Neo/eGFP-Puro)CVCL_RA11 (HT1080-Fluc-Neo/iRFP-Puro)CVCL_RA12 (HT1080-Fluc-Puro)
CVCL_RA13 (HT1080-hNIS-Neo/eGFP-Puro)CVCL_RA14 (HT1080-hNIS-Neo/Fluc-Puro)CVCL_RA15 (HT1080-hNIS-Neo/iRFP-Puro)
CVCL_RA16 (HT1080-hNIS-Puro)CVCL_RA17 (HT1080-iRFP-Puro)CVCL_L898 (HT1080-luc2)
CVCL_ZJ81 (HT1080-MFAP4 W235F-MH)CVCL_ZJ80 (HT1080-MFAP4 wt-MH)CVCL_5I99 (HT1080-Red-FLuc)
CVCL_6C48 (HT1080/DR4)CVCL_WM79 (HTC75)CVCL_D683 (HTD114)
CVCL_3318 (HX)CVCL_V634 (JH-2/TPA)CVCL_8437 (PEAZ-1)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
STR profile Source(s): ATCC; CCRID; CLS; Cosmic-CLP; DSMZ; ECACC; JCRB; KCLB; PubMed=11416159; PubMed=17254797; PubMed=25877200; RCB

CSF1PO11 (PubMed=17254797)
12 (ATCC; CCRID; CLS; Cosmic-CLP; DSMZ; ECACC; JCRB; KCLB; PubMed=25877200; RCB)
Penta D9,12
Penta E5,15

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/HT1080

PubMed=4132053; DOI=10.1002/1097-0142(197404)33:4<1027::AID-CNCR2820330419>3.0.CO;2-Z
Rasheed S., Nelson-Rees W.A., Toth E.M., Arnstein P., Gardner M.B.
Characterization of a newly derived human sarcoma cell line (HT-1080).
Cancer 33:1027-1033(1974)

PubMed=375235; DOI=10.1073/pnas.76.3.1288
Sherwin S.A., Sliski A.H., Todaro G.J.
Human melanoma cells have both nerve growth factor and nerve growth factor-specific receptors on their cell surfaces.
Proc. Natl. Acad. Sci. U.S.A. 76:1288-1292(1979)

PubMed=22282976; DOI=10.1093/carcin/1.1.21
Day R.S. III, Ziolkowski C.H.J., Scudiero D.A., Meyer S.A., Mattern M.R.
Human tumor cell strains defective in the repair of alkylation damage.
Carcinogenesis 1:21-32(1980)

PubMed=6652615; DOI=10.1016/0165-4608(83)90092-4
Chen T.-R., Hay R.J., Macy M.L.
Intercellular karyotypic similarity in near-diploid cell lines of human tumor origins.
Cancer Genet. Cytogenet. 10:351-362(1983)

PubMed=6538202; DOI=10.1083/jcb.98.3.1133
Azzarone B., Suarez H., Mingari M.C., Moretta L., Fauci A.S.
4F2 monoclonal antibody recognizes a surface antigen on spread human fibroblasts of embryonic but not of adult origin.
J. Cell Biol. 98:1133-1137(1984)

PubMed=3986962; DOI=10.1093/carcin/6.4.549
Watatani M., Ikenaga M., Hatanaka T., Kinuta M., Takai S.-I., Mori T., Kondo S.
Analysis of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced DNA damage in tumor cell strains from Japanese patients and demonstration of MNNG hypersensitivity of Mer xenografts in athymic nude mice.
Carcinogenesis 6:549-553(1985)

PubMed=3558490; DOI=10.1002/jcp.1041300303
Gupta R.S., Dudani A.K.
Species-specific differences in the toxicity of rhodamine 123 towards cultured mammalian cells.
J. Cell. Physiol. 130:321-327(1987)

Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=3413074; DOI=10.1073/pnas.85.16.6042
Pereira-Smith O.M., Smith J.R.
Genetic analysis of indefinite division in human cells: identification of four complementation groups.
Proc. Natl. Acad. Sci. U.S.A. 85:6042-6046(1988)

PubMed=11668190; DOI=10.1177/002215540104901105
Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=12068308; DOI=10.1038/nature00766
Davies H., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Azari S., Ahmadi N., Tehrani M.J., Shokri F.
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24726063; DOI=10.1186/1756-9966-33-33
Koelsche C., Renner M., Hartmann W., Brandt R., Lehner B., Waldburger N., Alldinger I., Schmitt T., Egerer G., Penzel R., Wardelmann E., Schirmacher P., von Deimling A., Mechtersheimer G.
TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities.
J. Exp. Clin. Cancer Res. 33:33.1-33.8(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=26368816; DOI=10.1371/journal.pone.0133813
Li L., Paz A.C., Wilky B.A., Johnson B., Galoian K., Rosenberg A., Hu G., Tinoco G., Bodamer O.A., Trent J.C.
Treatment with a small molecule mutant IDH1 inhibitor suppresses tumorigenic activity and decreases production of the oncometabolite 2-hydroxyglutarate in human chondrosarcoma cells.
PLoS ONE 10:E0133813-E0133813(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

Cell line collections ATCC; CCL-121
ATCC; CRL-7951 - Discontinued
BCRC; 60037
BCRJ; 0110
CLS; 300216/p517_HT-1080
ECACC; 85111505
IBRC; C10104
ICLC; HTL98016
JCRB; IFO50354
KCB; KCB 2013029YJ
KCLB; 10121
NCBI_Iran; C437
RCB; RCB1956 - Discontinued
TKG; TKG 0202
Cell line databases/resources CLO; CLO_0004266
CLO; CLO_0004276
MCCL; MCC:0000210
CLDB; cl1735
CLDB; cl1736
CLDB; cl1737
CLDB; cl1738
CLDB; cl1740
CLDB; cl1741
CLDB; cl1742
CLDB; cl4913
CCRID; 1101HUM-PUMC000070
Cell_Model_Passport; SIDM00828
Cosmic-CLP; 907064
DepMap; ACH-000054
IGRhCellID; HT1080
Lonza; 744
TOKU-E; 1963
Anatomy/cell type resources BTO; BTO:0001282
Biological sample resources BioSample; SAMN01821563
BioSample; SAMN01821634
BioSample; SAMN01821685
BioSample; SAMN01821731
BioSample; SAMN03471913
BioSample; SAMN10987635
Chemistry resources ChEMBL-Cells; CHEMBL3308396
ChEMBL-Targets; CHEMBL614580
GDSC; 907064
PharmacoDB; HT1080_625_2019
Encyclopedic resources Wikidata; Q5636047
Experimental variables resources EFO; EFO_0002059
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM185089
GEO; GSM185090
GEO; GSM256074
GEO; GSM256075
GEO; GSM256076
GEO; GSM256077
GEO; GSM256078
GEO; GSM256079
GEO; GSM256080
GEO; GSM256081
GEO; GSM256082
GEO; GSM256083
GEO; GSM256084
GEO; GSM256085
GEO; GSM256086
GEO; GSM256087
GEO; GSM256088
GEO; GSM256089
GEO; GSM256090
GEO; GSM256091
GEO; GSM256092
GEO; GSM256093
GEO; GSM256094
GEO; GSM256095
GEO; GSM256096
GEO; GSM256097
GEO; GSM256098
GEO; GSM256099
GEO; GSM256100
GEO; GSM256101
GEO; GSM256102
GEO; GSM256103
GEO; GSM256104
GEO; GSM256105
GEO; GSM256106
GEO; GSM256107
GEO; GSM256108
GEO; GSM256109
GEO; GSM256110
GEO; GSM256111
GEO; GSM256112
GEO; GSM256113
GEO; GSM256114
GEO; GSM827307
GEO; GSM887136
GEO; GSM888207
GEO; GSM1669908
GEO; GSM1676302
GEO; GSM1701637
Polymorphism and mutation databases Cosmic; 716177
Cosmic; 716188
Cosmic; 724819
Cosmic; 907064
Cosmic; 912000
Cosmic; 1045409
Cosmic; 1067221
Cosmic; 1933190
Cosmic; 2009505
Cosmic; 2301553
Cosmic; 2307731
Cosmic; 2560245
Cosmic; 2764533
IARC_TP53; 21378
LiGeA; CCLE_463
Progenetix; CVCL_0317
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update16-Dec-2021
Version number39