ID   HT22
AC   CVCL_0321
SY   HT-22
DR   BTO; BTO:0003037
DR   MCCL; MCC:0000214
DR   ChEMBL-Cells; CHEMBL3307590
DR   ChEMBL-Targets; CHEMBL614316
DR   Lonza; 248
DR   Millipore; SCC129
DR   PRIDE; PXD001597
DR   Wikidata; Q54896579
RX   PubMed=7953717;
RX   PubMed=9292733;
RX   PubMed=19135458;
RX   PubMed=26227174;
CC   Characteristics: Highly sensitive to glutamate and is therefore used to study glutamate-induced toxicity in neuronal cells.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [tsA58].
CC   Omics: Secretome proteome analysis.
CC   Derived from sampling site: Brain; hippocampus; neurons.
ST   Source(s): Millipore
ST   Mouse STR 1-1: 10,11
ST   Mouse STR 1-2: 13,17
ST   Mouse STR 11-2: 15,17,18
ST   Mouse STR 12-1: 20
ST   Mouse STR 13-1: 16.2
ST   Mouse STR 15-3: 20.3
ST   Mouse STR 17-2: 12,13,14
ST   Mouse STR 18-3: 17,19
ST   Mouse STR 19-2: 11,12
ST   Mouse STR 2-1: 9
ST   Mouse STR 3-2: 14,15
ST   Mouse STR 4-2: 18.3,19.3,20.3
ST   Mouse STR 5-5: 13,14,15
ST   Mouse STR 6-4: 15.3
ST   Mouse STR 6-7: 12
ST   Mouse STR 7-1: 29
ST   Mouse STR 8-1: 15
ST   Mouse STR X-1: 25
OX   NCBI_TaxID=10090; ! Mus musculus
HI   CVCL_U378 ! HT4
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 29-10-20; Version: 15
RX   PubMed=7953717; DOI=10.1016/0006-8993(94)90334-4;
RA   Davis J.B., Maher P.;
RT   "Protein kinase C activation inhibits glutamate-induced cytotoxicity
RT   in a neuronal cell line.";
RL   Brain Res. 652:169-173(1994).
RX   PubMed=9292733; DOI=10.1016/S0896-6273(00)80953-8;
RA   Li Y., Maher P., Schubert D.;
RT   "A role for 12-lipoxygenase in nerve cell death caused by glutathione
RT   depletion.";
RL   Neuron 19:453-463(1997).
RX   PubMed=19135458; DOI=10.1016/j.lfs.2008.12.008;
RA   Liu J., Li L., Suo W.Z.;
RT   "HT22 hippocampal neuronal cell line possesses functional cholinergic
RT   properties.";
RL   Life Sci. 84:267-271(2009).
RX   PubMed=26227174; DOI=10.1002/pmic.201400623;
RA   Woo J.-M., Han D.-H., Park J.-H., Kim S.-J., Kim Y.-S.;
RT   "In-depth characterization of the secretome of mouse CNS cell lines by
RT   LC-MS/MS without prefractionation.";
RL   Proteomics 15:3617-3622(2015).