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Cellosaurus Hs 746.T (CVCL_0333)

[Text version]

Cell line name Hs 746.T
Synonyms Hs 746T; HS 746T; Hs-746T; HS-746T; Hs746T; HS746T; Hs746-T; 746T
Accession CVCL_0333
Resource Identification Initiative To cite this cell line use: Hs 746.T (RRID:CVCL_0333)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: MET genetic alteration cell panel (ATCC TCP-1036).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.16
East Asian, North2.9
East Asian, South0
South Asian0.58
European, North65.13
European, South31.23
Disease Gastric adenocarcinoma (NCIt: C4004)
Derived from metastatic site: Left leg muscle.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_S315 ! Hs 746.Sk
CVCL_N486 ! Hs 750.T
Sex of cell Male
Age at sampling 74Y
Category Cancer cell line
STR profile Source(s): AddexBio; ATCC; Cosmic-CLP; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133823
D3S135814,15
D5S81811,13
D7S8208
D8S117913,14
D13S31710
D16S53911
D18S5115,16
D19S43314
D21S1129
FGA25
Penta D9
Penta E7,9
TH019
TPOX8,10
vWA15,17 (AddexBio; ATCC; Cosmic-CLP)
17 (PubMed=25877200)

Run an STR similarity search on this cell line
Web pages http://www.cellresource.cn/fdetail.aspx?id=836
Publications

PubMed=283258; DOI=10.1093/jnci/62.2.225
Smith H.S.
In vitro properties of epithelial cell lines established from human carcinomas and nonmalignant tissue.
J. Natl. Cancer Inst. 62:225-230(1979)

PubMed=761205
Smith H.S., Springer E.L., Hackett A.J.
Nuclear ultrastructure of epithelial cell lines derived from human carcinomas and nonmalignant tissues.
Cancer Res. 39:332-344(1979)

PubMed=6500159; DOI=10.1159/000163283
Gershwin M.E., Lentz D., Owens R.B.
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Exp. Cell Biol. 52:361-370(1984)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24807215; DOI=10.1038/ncomms4830
Liu J., McCleland M., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H., Wan Y., Chopra V., Yaylaoglu M.B., Yuan W., Ha C., Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R., Zhang Z.
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Nat. Commun. 5:3830-3830(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections AddexBio; C0023003/4957
ATCC; HTB-135
CCTCC; GDC0069
KCB; KCB 2013048YJ
Cell line databases/resources CCLE; HS746T_STOMACH
CCRID; 3142C0001000000068
Cell_Model_Passport; SIDM00665
Cosmic-CLP; 1240151
DepMap; ACH-000616
GDSC; 1240151
LINCS_LDP; LCL-1883
Ontologies CLO; CLO_0004094
EFO; EFO_0006589
MCCL; MCC:0000229
Biological sample resources BioSample; SAMN03470907
BioSample; SAMN03472714
BioSample; SAMN10987647
Chemistry resources ChEMBL-Cells; CHEMBL3307498
ChEMBL-Targets; CHEMBL614579
PharmacoDB; Hs746T_594_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM267418
GEO; GSM267425
GEO; GSM267432
GEO; GSM267439
GEO; GSM552359
GEO; GSM562402
GEO; GSM827402
GEO; GSM844566
GEO; GSM887115
GEO; GSM888186
GEO; GSM1237674
GEO; GSM1237699
GEO; GSM1374552
GEO; GSM1669898
Other Wikidata; Q54895986
Polymorphism and mutation databases Cosmic; 1187275
Cosmic; 1329184
Cosmic; 1460704
Cosmic; 1479630
Cosmic; 1482075
Cosmic; 1995447
Cosmic; 2069776
Cosmic; 2484963
LiGeA; CCLE_544
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number26