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Cellosaurus HuT 78 (CVCL_0337)

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Cell line name HuT 78
Synonyms HUT 78; HuT-78; HUT-78; HuT78; Hut78; HUT78; NCI-H78
Accession CVCL_0337
Resource Identification Initiative To cite this cell line use: HuT 78 (RRID:CVCL_0337)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
Doubling time: 26 hours (PubMed=6244013); 26 hours (NIH-ARP); ~65 hours (ATCC).
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Omics: Virome analysis using RNAseq.
Anecdotal: For a number of years it was not known that H9 used by Gallo's lab to isolate HIV-1 (HTLV-III) was in fact a clone of Hut 78 from Minna's lab (PubMed=2567177). This created a controversy between the labs of Minna and Gallo (PubMed=2193399).
Derived from sampling site: Peripheral blood.
Sequence variations Homozygous for TP53 p.Arg196Ter (c.586C>T) (PubMed=2144611).
Disease Mycosis fungoides and Sezary syndrome (NCIt: C9265)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1240 (H9)CVCL_X617 (HUT 78/HIV-1SF2)CVCL_X682 (HUT 78/HIV-2D194)
CVCL_X683 (HUT 78/HIV-2D205)CVCL_X611 (HUT 78/SIV-BK28)CVCL_X616 (HUT 78/SIV-BK44)
CVCL_X609 (HUT 78/SIVmac251)CVCL_0325 (HuT78B1)CVCL_9472 (PM1)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): ATCC; CLS; PubMed=11416159; PubMed=25877200; RCB; TKG

D7S8208,11 (ATCC; CLS; RCB; TKG)
8 (PubMed=25877200)
Penta D9
Penta E13,15
Web pages http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-70.html

Gazdar A.F., Carney D.N., Bunn P.A. Jr., Russell E.K., Jaffe E.S., Schechter G.P., Guccion J.G.
Mitogen requirements for the in vitro propagation of cutaneous T-cell lymphomas.
Blood 55:409-417(1980)

PubMed=3495441; DOI=10.1002/eji.1830170503
Kanowith-Klein S., Saxon A., Uittenbogaart C.H.
Constitutive production of B cell differentiation factor-like activity by human T and B cell lines.
Eur. J. Immunol. 17:593-598(1987)

PubMed=2144611; DOI=10.1128/MCB.10.10.5502
Cheng J., Haas M.
Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines.
Mol. Cell. Biol. 10:5502-5509(1990)

PubMed=2193399; DOI=10.1126/science.2193399
Rubinstein E.
The untold story of HUT78.
Science 248:1499-1507(1990)

Heyman M., Grander D., Brondum-Nielsen K., Cederblad B., Liu Y., Xu B., Einhorn S.
Interferon system defects in malignant T-cells.
Leukemia 8:425-434(1994)

PubMed=8806089; DOI=10.1002/jcb.240630502
Gazdar A.F., Minna J.D.
NCI series of cell lines: an historical perspective.
J. Cell. Biochem. 63 Suppl. 24:1-11(1996)

PubMed=8806090; DOI=10.1002/jcb.240630503
Bunn P.A. Jr., Foss F.M.
T-cell lymphoma cell lines (HUT102 and HUT78) established at the National Cancer Institute: history and importance to understanding the biology, clinical features, and therapy of cutaneous T-cell lymphomas (CTCL) and adult T-cell leukemia-lymphomas (ATLL).
J. Cell. Biochem. 63 Suppl. 24:12-23(1996)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x
Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=10570904; DOI=10.1007/s100380050178
Ariyama Y., Mori T., Shinomiya T., Sakabe T., Fukuda Y., Kanamaru A., Yamada Y., Isobe M., Seto M., Nakamura Y., Inazawa J.
Chromosomal imbalances in adult T-cell leukemia revealed by comparative genomic hybridization: gains at 14q32 and 2p16-22 in cell lines.
J. Hum. Genet. 44:357-363(1999)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25355872; DOI=10.1128/JVI.02570-14
Cao S., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z., O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
J. Virol. 89:713-729(2015)

Cell line collections ATCC; TIB-161
BCRC; 60522
BCRJ; 0370
CLS; 300338/p653_HUT-78
ECACC; 88041901
KCLB; 90078
NCBI_Iran; C185
NIH-ARP; 89-218
RCB; RCB1934
TKG; TKG 0375
Cell line databases/resources CLDB; cl1778
CLDB; cl1779
CCRID; 3111C0001CCC000190
CCRID; 3131C0001000700027
CCRID; 3131C0001001200004
Cell_Model_Passport; SIDM00851
CGH-DB; 9026-4
IGRhCellID; HuT78
Lonza; 813
TOKU-E; 1977
Ontologies BTO; BTO:0001945
CLO; CLO_0004304
CLO; CLO_0051010
EFO; EFO_0002209
MCCL; MCC:0000233
Biological sample resources BioSample; SAMN01821566
BioSample; SAMN03471940
BioSample; SAMN03473203
Chemistry resources ChEMBL-Cells; CHEMBL3307500
ChEMBL-Targets; CHEMBL613978
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887154
GEO; GSM888226
GEO; GSM1374569
Other Wikidata; Q54896909
Polymorphism and mutation databases Cosmic; 724829
Cosmic; 1551450
Cosmic; 2153070
Cosmic; 2402468
IARC_TP53; 185