ID   HuT 78
AC   CVCL_0337
SY   Hut 78; HUT 78; HuT-78; HUT-78; HuT78; Hut78; HUT78; NCI-H78
DR   BTO; BTO:0001945
DR   CLO; CLO_0004304
DR   CLO; CLO_0051010
DR   EFO; EFO_0002209
DR   MCCL; MCC:0000233
DR   CLDB; cl1778
DR   CLDB; cl1779
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-2770
DR   ATCC; TIB-161
DR   ATCC; CRM-TIB-161
DR   BCRC; 60522
DR   BCRJ; 0370
DR   BioSample; SAMN01821566
DR   BioSample; SAMN03471940
DR   BioSample; SAMN03473203
DR   BioSample; SAMN10987600
DR   CCLE; HUT78_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
DR   CCRID; 3111C0001CCC000190
DR   CCRID; 3131C0001000700027
DR   CCRID; 3131C0001000700206
DR   CCRID; 3131C0001001200004
DR   CCRID; 3142C0001000000333
DR   CCTCC; GDC0307
DR   Cell_Model_Passport; SIDM00851
DR   CGH-DB; 9026-4
DR   ChEMBL-Cells; CHEMBL3307500
DR   ChEMBL-Targets; CHEMBL613978
DR   CLS; 300338/p653_HUT-78
DR   Cosmic; 724829
DR   Cosmic; 1551450
DR   Cosmic; 2153070
DR   Cosmic; 2402468
DR   Cosmic; 2765583
DR   DepMap; ACH-000509
DR   ECACC; 88041901
DR   GEO; GSM887154
DR   GEO; GSM888226
DR   GEO; GSM1374569
DR   IARC_TP53; 185
DR   IGRhCellID; HuT78
DR   KCLB; 90078
DR   LiGeA; CCLE_696
DR   LINCS_LDP; LCL-2005
DR   Lonza; 813
DR   NCBI_Iran; C185
DR   NIH-ARP; 89-218
DR   PharmacoDB; HuT78_647_2019
DR   Progenetix; CVCL_0337
DR   RCB; RCB1934
DR   TKG; TKG 0375
DR   TOKU-E; 1977
DR   Wikidata; Q54896909
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=2144611;
RX   PubMed=2193399;
RX   PubMed=3495441;
RX   PubMed=6244013;
RX   PubMed=6954533;
RX   PubMed=8127147;
RX   PubMed=8806089;
RX   PubMed=8806090;
RX   PubMed=8806092;
RX   PubMed=9738977;
RX   PubMed=10570904;
RX   PubMed=12068308;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=25355872;
RX   PubMed=30285677;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-70.html
WW   http://www.nibsc.org/Default.aspx?pageid=597&id=0002&theme=default
WW   http://www.cellresource.cn/fdetail.aspx?id=190
WW   http://www.cellresource.cn/fdetail.aspx?id=597
WW   http://www.cellresource.cn/fdetail.aspx?id=1585
WW   http://www.cellresource.cn/fdetail.aspx?id=1711
WW   http://www.cellresource.cn/fdetail.aspx?id=1984
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
CC   Doubling time: 26 hours (PubMed=6244013); 26 hours (NIH-ARP); ~65 hours (ATCC).
CC   Sequence variation: Heterozygous for NRAS p.Gln61Lys (c.181C>A) (ClinVar=VCV000073058) (PubMed=12068308; CCLE).
CC   Sequence variation: Homozygous for TP53 p.Arg196Ter (c.586C>T) (ClinVar=VCV000043589) (PubMed=2144611; CCLE).
CC   Omics: Deep exome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Omics: Virome analysis using RNAseq.
CC   Genome ancestry: African=0.32%; Native American=0.76%; East Asian, North=2.56%; East Asian, South=0%; South Asian=0.32%; European, North=68.01%; European, South=28.04% (PubMed=30894373).
CC   Anecdotal: For a number of years it was not known that H9 used by Gallo's lab to isolate HIV-1 (HTLV-III) was in fact a clone of Hut 78 from Minna's lab (PubMed=2567177). This created a controversy between the labs of Minna and Gallo (PubMed=2193399).
CC   Derived from sampling site: Peripheral blood.
ST   Source(s): ATCC; CCRID; CLS; PubMed=11416159; PubMed=25877200; RCB; TKG
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 8,12
ST   D16S539: 11,12
ST   D18S51: 18
ST   D19S433: 14
ST   D21S11: 30
ST   D2S1338: 20,25
ST   D3S1358: 15,16
ST   D5S818: 11,12
ST   D7S820: 8 (PubMed=25877200)
ST   D7S820: 8,11 (ATCC; CCRID; CLS; RCB; TKG)
ST   D8S1179: 12,14
ST   FGA: 21,25
ST   Penta D: 9
ST   Penta E: 13,15
ST   TH01: 8,9
ST   TPOX: 8,9
ST   vWA: 14,15
DI   NCIt; C9265; Mycosis fungoides and Sezary syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 12-01-21; Version: 29
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=2144611; DOI=10.1128/MCB.10.10.5502;
RA   Cheng J., Haas M.;
RT   "Frequent mutations in the p53 tumor suppressor gene in human leukemia
RT   T-cell lines.";
RL   Mol. Cell. Biol. 10:5502-5509(1990).
//
RX   PubMed=2193399; DOI=10.1126/science.2193399;
RA   Rubinstein E.;
RT   "The untold story of HUT78.";
RL   Science 248:1499-1507(1990).
//
RX   PubMed=3495441; DOI=10.1002/eji.1830170503;
RA   Kanowith-Klein S., Saxon A., Uittenbogaart C.H.;
RT   "Constitutive production of B cell differentiation factor-like
RT   activity by human T and B cell lines.";
RL   Eur. J. Immunol. 17:593-598(1987).
//
RX   PubMed=6244013; DOI=10.1182/blood.V55.3.409.409;
RA   Gazdar A.F., Carney D.N., Bunn P.A. Jr., Russell E.K., Jaffe E.S.,
RA   Schechter G.P., Guccion J.G.;
RT   "Mitogen requirements for the in vitro propagation of cutaneous T-cell
RT   lymphomas.";
RL   Blood 55:409-417(1980).
//
RX   PubMed=6954533; DOI=10.1073/pnas.79.7.2194;
RA   Westin E.H., Gallo R.C., Arya S.K., Eva A., Souza L.M., Baluda M.A.,
RA   Aaronson S.A., Wong-Staal F.;
RT   "Differential expression of the amv gene in human hematopoietic
RT   cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982).
//
RX   PubMed=8127147;
RA   Heyman M., Grander D., Brondum-Nielsen K., Cederblad B., Liu Y.,
RA   Xu B., Einhorn S.;
RT   "Interferon system defects in malignant T-cells.";
RL   Leukemia 8:425-434(1994).
//
RX   PubMed=8806089; DOI=10.1002/jcb.240630502;
RA   Gazdar A.F., Minna J.D.;
RT   "NCI series of cell lines: an historical perspective.";
RL   J. Cell. Biochem. 63 Suppl. 24:1-11(1996).
//
RX   PubMed=8806090; DOI=10.1002/jcb.240630503;
RA   Bunn P.A. Jr., Foss F.M.;
RT   "T-cell lymphoma cell lines (HUT102 and HUT78) established at the
RT   National Cancer Institute: history and importance to understanding the
RT   biology, clinical features, and therapy of cutaneous T-cell lymphomas
RT   (CTCL) and adult T-cell leukemia-lymphomas (ATLL).";
RL   J. Cell. Biochem. 63 Suppl. 24:12-23(1996).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. 63 Suppl. 24:32-91(1996).
//
RX   PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x;
RA   Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T.,
RA   Aizawa Y., Ueda R., Seto M.;
RT   "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not
RT   in adult T-cell leukemia.";
RL   Jpn. J. Cancer Res. 89:712-718(1998).
//
RX   PubMed=10570904; DOI=10.1007/s100380050178;
RA   Ariyama Y., Mori T., Shinomiya T., Sakabe T., Fukuda Y., Kanamaru A.,
RA   Yamada Y., Isobe M., Seto M., Nakamura Y., Inazawa J.;
RT   "Chromosomal imbalances in adult T-cell leukemia revealed by
RT   comparative genomic hybridization: gains at 14q32 and 2p16-22 in cell
RT   lines.";
RL   J. Hum. Genet. 44:357-363(1999).
//
RX   PubMed=12068308; DOI=10.1038/nature00766;
RA   Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S.,
RA   Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N.,
RA   Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J.,
RA   Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S.,
RA   Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.,
RA   Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J.,
RA   Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A.,
RA   Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T.,
RA   Weber B.L., Seigler H.F., Darrow T.L., Paterson H., Marais R.,
RA   Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.;
RT   "Mutations of the BRAF gene in human cancer.";
RL   Nature 417:949-954(2002).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=25355872; DOI=10.1128/JVI.02570-14;
RA   Cao S., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z.,
RA   O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.;
RT   "High-throughput RNA sequencing-based virome analysis of 50 lymphoma
RT   cell lines from the Cancer Cell Line Encyclopedia project.";
RL   J. Virol. 89:713-729(2015).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5;
RA   Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X.,
RA   Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H.,
RA   Koeffler H.P.;
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940-940(2018).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//