Cellosaurus IB3-1 (CVCL_0338)

Cell line name IB3-1
Synonyms IB3
Accession CVCL_0338
Resource Identification Initiative To cite this cell line use: IB3-1 (RRID:CVCL_0338)
Comments Sequence variation: Heterozygous for CFTR p.Phe508del and p.Trp1282Ter (PubMed=15463957).
Transformant: Ad12-SV40.
Omics: Proteome analysis by 2D-DE/MS.
Disease Cystic fibrosis (NCIt: C2975)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4462 (IB3-1/C38)CVCL_4461 (IB3-1/S9)
Sex of cell Male
Category Transformed cell line
STR profile Source(s): ATCC

Web pages http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/i/cell-lines-detail-527.html

PubMed=1849726; DOI=10.1165/ajrcmb/4.4.313
Zeitlin P.L., Lu L., Rhim J.S., Cutting G., Stetten G., Kieffer K.A., Craig R., Guggino W.B.
A cystic fibrosis bronchial epithelial cell line: immortalization by adeno-12-SV40 infection.
Am. J. Respir. Cell Mol. Biol. 4:313-319(1991)

PubMed=1380129; DOI=10.1038/358581a0
Egan M., Flotte T.R., Afione S.A., Solow R., Zeitlin P.L., Carter B.J., Guggino W.B.
Defective regulation of outwardly rectifying Cl- channels by protein kinase A corrected by insertion of CFTR.
Nature 358:581-584(1992)

Flotte T.R., Afione S.A., Solow R., Drumm M.L., Markakis D., Guggino W.B., Zeitlin P.L., Carter B.J.
Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter.
J. Biol. Chem. 268:3781-3790(1993)

PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040
Gruenert D.C., Willems M., Cassiman J.J., Frizzell R.A.
Established cell lines used in cystic fibrosis research.
J. Cyst. Fibros. 3:191-196(2004)

PubMed=16512671; DOI=10.1021/pr050319o
Singh O.V., Vij N., Mogayzel P.J. Jr., Jozwik C., Pollard H.B., Zeitlin P.L.
Pharmacoproteomics of 4-phenylbutyrate-treated IB3-1 cystic fibrosis bronchial epithelial cells.
J. Proteome Res. 5:562-571(2006)

PubMed=18441018; DOI=10.1194/jlr.M700388-JLR200
Andersson C., Al-Turkmani M.R., Savaille J.E., Alturkmani R., Katrangi W., Cluette-Brown J.E., Zaman M.M., Laposata M., Freedman S.D.
Cell culture models demonstrate that CFTR dysfunction leads to defective fatty acid composition and metabolism.
J. Lipid Res. 49:1692-1700(2008)

Cell line collections ATCC; CRL-2777 - Discontinued
ATCC; JHU-52 - Discontinued
BCRJ; 0114
Ontologies BTO; BTO:0004445
CLO; CLO_0004329
EFO; EFO_0001194
MCCL; MCC:0000234