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Cellosaurus INS-1E (CVCL_0351)

[Text version]
Cell line name INS-1E
Synonyms INS1-E; INS1E
Accession CVCL_0351
Resource Identification Initiative To cite this cell line use: INS-1E (RRID:CVCL_0351)
Comments Characteristics: Used in numerous studies investigating the mechanisms of glucose stimulated insulin secretion. Is glucose responsive in a physiological range with substantial insulin content levels and a robust metabolism-secretion coupling (PubMed=30310992).
Transformant: NCIt; C17262; X-Ray.
Omics: Insulin secretory granules proteome analysis.
Caution: This cell line is owned by the University of Geneva, Switzerland, who is the sole authorized distributor for both commercial and non-commercial research use.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease Rat insulinoma (NCIt: C121566)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH.
Hierarchy Parent: CVCL_0352 (INS-1)
Sex of cell Male
Age at sampling 666D
Category Cancer cell line
Web pages https://www.unige.ch/unitec/files/9915/8470/0115/TechOffer739_INS-1E_cell_line.pdf
Publications

PubMed=14592952; DOI=10.1210/en.2003-1099
Merglen A., Theander S., Rubi B., Chaffard G., Wollheim C.B., Maechler P.
Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells.
Endocrinology 145:667-678(2004)

PubMed=22569486; DOI=10.1016/j.jprot.2012.04.023
Schvartz D., Brunner Y., Coute Y., Foti M., Wollheim C.B., Sanchez J.-C.
Improved characterization of the insulin secretory granule proteomes.
J. Proteomics 75:4620-4631(2012)

PubMed=30310992; DOI=10.1007/s00424-018-2215-z
Casimir M., Chaffard G., Maechler P.
Resveratrol long-term treatment differentiates INS-1E beta-cell towards improved glucose response and insulin secretion.
Pflugers Arch. 471:337-345(2019)

Cross-references
Cell line collections (Providers) AddexBio; C0018009/4675 - Discontinued
Cell line databases/resources MCCL; MCC:0000245
Lonza; 1137
Anatomy/cell type resources BCGO; BCGO_0000120
BTO; BTO:0003317
Chemistry resources ChEMBL-Cells; CHEMBL4651375
PubChem_Cell_line; CVCL_0351
Encyclopedic resources Wikidata; Q54897749
Proteomic databases PRIDE; PXD006544
PRIDE; PXD008988
PRIDE; PXD011329
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number16