ID   INS-1
AC   CVCL_0352
SY   INS1
DR   BTO; BTO:0002135
DR   EFO; EFO_0002529
DR   MCCL; MCC:0000246
DR   AddexBio; C0018007/371
DR   CCRID; 1101RAT-PUMC000378
DR   ChEMBL-Cells; CHEMBL3308040
DR   ChEMBL-Targets; CHEMBL613545
DR   CLS; 300471
DR   KCB; KCB 2010005YJ
DR   Lonza; 301
DR   PRIDE; PXD013232
DR   PubChem_Cell_line; CVCL_0352
DR   TOKU-E; 3996
DR   Wikidata; Q54897741
RX   PubMed=1370150;
RX   PubMed=8697299;
RX   PubMed=22538498;
RX   PubMed=36180704;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/i/cell-lines-detail-31.html
CC   Characteristics: Established from the transplantable insulinoma RIN.
CC   Transformant: NCIt; C17262; X-Ray.
CC   Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
CC   Cell type: Pancreatic beta cell; CL=CL_0000169.
CC   Breed/subspecies: NEDH.
DI   NCIt; C121566; Rat insulinoma
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
OI   CVCL_J993 ! INS-2
OI   CVCL_3584 ! RIN-m
OI   CVCL_D163 ! RIN-r
SX   Male
AG   666D
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 23
//
RX   PubMed=1370150; DOI=10.1210/endo.130.1.1370150;
RA   Asfari M., Janjic D., Meda P., Li G.-D., Halban P.A., Wollheim C.B.;
RT   "Establishment of 2-mercaptoethanol-dependent differentiated
RT   insulin-secreting cell lines.";
RL   Endocrinology 130:167-178(1992).
//
RX   PubMed=8697299;
RA   Poitout V., Olson L.K., Robertson R.P.;
RT   "Insulin-secreting cell lines: classification, characteristics and
RT   potential applications.";
RL   Diabetes Metab. 22:7-14(1996).
//
RX   PubMed=22538498; DOI=10.1159/000338793;
RA   Grozinsky-Glasberg S., Shimon I., Rubinfeld H.;
RT   "The role of cell lines in the study of neuroendocrine tumors.";
RL   Neuroendocrinology 96:173-187(2012).
//
RX   PubMed=36180704; DOI=10.1007/978-1-0716-2593-4_35;
RA   Zibolka J., Bahr I., Peschke E., Muhlbauer E., Bazwinsky-Wutschke I.;
RT   "Human and rodent cell lines as models of functional
RT   melatonin-responsive pancreatic islet cells.";
RL   Methods Mol. Biol. 2550:329-352(2022).
//