Home  |  Contact

Cellosaurus JAR (CVCL_0360)

[Text version]

Cell line name JAR
Synonyms Jar; JAr; JaR
Accession CVCL_0360
Resource Identification Initiative To cite this cell line use: JAR (RRID:CVCL_0360)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~20-30 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Caution: Established from the trophoblastic tumor of the placenta of a 24 year old woman, but the cell line is from the male fetus.
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.66
East Asian, North2.4
East Asian, South0
South Asian1.4
European, North42.28
European, South23.14
Disease Gestational choriocarcinoma (NCIt: C4646)
Gestational choriocarcinoma (ORDO: Orphanet_99926)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
Sex of cell Male
Age at sampling Fetus
Category Cancer cell line
STR profile Source(s): ATCC; CLS; Cosmic-CLP; DSMZ; KCLB

D3S135814 (CLS)
16,17 (KCLB)
Penta D9,11
Penta E10,12

Run an STR similarity search on this cell line

Pattillo R.A., Ruckert A.C.F., Hussa R.O., Bernstein R., Delfs E.
The JAr cell line -- continuous human multihormone production and controls.
In Vitro 6:398-399(1971)

Sasaki S., Katayama P.K., Roesler M., Pattillo R.A., Mattingly R.F., Ohkawa K.
Cytogenetic analysis of choriocarcinoma cell lines.
Nihon Sanka Fujinka Gakkai Zasshi 34:2253-2256(1982)

PubMed=4038916; DOI=10.1016/0165-4608(85)90052-4
Sheppard D.M., Fisher R.A., Lawler S.D.
Karyotypic analysis and chromosome polymorphisms in four choriocarcinoma cell lines.
Cancer Genet. Cytogenet. 16:251-258(1985)

PubMed=2878840; DOI=10.1016/0020-7292(86)90088-3
Yamashita K., Nakamura T., Shimizu T., Katagiri M., Ikeda H.
Expression of HLA class I and class II antigens in human choriocarcinoma cell lines.
Int. J. Gynecol. Obstet. 24:301-307(1986)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=2720636; DOI=10.1016/0165-4608(89)90664-X
Surti U., Habibian R.
Chromosomal rearrangement in choriocarcinoma cell lines.
Cancer Genet. Cytogenet. 38:229-240(1989)

PubMed=7937597; DOI=10.1016/0143-4004(94)90008-6
Grummer R., Hohn H.-P., Mareel M.M., Denker H.-W.
Adhesion and invasion of three human choriocarcinoma cell lines into human endometrium in a three-dimensional organ culture system.
Placenta 15:411-429(1994)

PubMed=7716126; DOI=10.1016/0143-4004(95)90079-9
Mitchell A.M., Yap A.S., Payne E.J., Manley S.W., Mortimer R.H.
Characterization of cell polarity and epithelial junctions in the choriocarcinoma cell line, JAR.
Placenta 16:31-39(1995)

Ganapathy V., Prasad P.D., Leibach F.H.
(In) Human cell culture. Vol. 2. Cancer Cell Lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.141-147; Kluwer Academic Publishers; New York (1999)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24098444; DOI=10.1371/journal.pone.0076205
Vuoristo S., Toivonen S., Weltner J., Mikkola M., Ustinov J., Trokovic R., Palgi J., Lund R., Tuuri T., Otonkoski T.
A novel feeder-free culture system for human pluripotent stem cell culture and induced pluripotent stem cell derivation.
PLoS ONE 8:E76205-E76205(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28161053; DOI=10.1016/j.placenta.2016.12.007
Abou-Kheir W., Barrak J., Hadadeh O., Daoud G.
HTR-8/SVneo cell line contains a mixed population of cells.
Placenta 50:1-7(2017)

PubMed=28724925; DOI=10.1038/s41598-017-06364-z
Rothbauer M., Patel N., Gondola H., Siwetz M., Huppertz B., Ertl P.
A comparative study of five physiological key parameters between four different human trophoblast-derived cell lines.
Sci. Rep. 7:5892-5892(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections ATCC; HTB-144
BCRC; 60491
CLS; 300221/p449_JAR
KCLB; 30144
Cell line databases/resources CCLE; JAR_PLACENTA
CCRID; 3131C0001000700028
CCRID; 3131C0001000700156
Cell_Model_Passport; SIDM01039
Cosmic-CLP; 907175
DepMap; ACH-001529
TOKU-E; 2064
Ontologies BTO; BTO:0001585
CLO; CLO_0007011
EFO; EFO_0002211
MCCL; MCC:0000254
Biological sample resources BioSample; SAMN01821568
BioSample; SAMN01821637
BioSample; SAMN03472717
Chemistry resources ChEMBL-Cells; CHEMBL3307657
ChEMBL-Targets; CHEMBL614587
GDSC; 907175
PharmacoDB; JAR_676_2019
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827264
GEO; GSM1669947
Other Wikidata; Q54898511
Polymorphism and mutation databases Cosmic; 907175
Cosmic; 2077193
IARC_TP53; 21417
Progenetix; CVCL_0360
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number33