Cellosaurus JEG-3 (CVCL_0363)

Cell line name JEG-3
Synonyms Jeg-3; JEG3; Jeg3; jeg3
Accession CVCL_0363
Resource Identification Initiative To cite this cell line use: JEG-3 (RRID:CVCL_0363)
Comments Doubling time: ~24 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Disease Gestational choriocarcinoma (NCIt: C4646)
Derived from metastatic site: Brain.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_9559 (AC1 [Human gestational choriocarcinoma])CVCL_IV65 (JEG-3/A3-1A7)CVCL_6922 (JEG-3/VP16)
CVCL_7167 (TEC61)
Originate from same individual CVCL_0044 ! BeWo
Sex of cell Male
Category Cancer cell line
STR profile Source(s): AddexBio; ATCC; CLS; Cosmic-CLP; DSMZ; KCLB

D3S135815 (CLS)
15,16 (KCLB)
Penta D9,12
Penta E8,12
Web pages http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/j/cell-lines-detail-251.html

PubMed=5103722; DOI=10.1210/jcem-32-5-683
Kohler P.O., Bridson W.E.
Isolation of hormone-producing clonal lines of human choriocarcinoma.
J. Clin. Endocrinol. Metab. 32:683-687(1971)

PubMed=62839; DOI=10.1093/jnci/56.5.911
Lieblich J.M., Weintraub B.D., Krauth G.H., Kohler P.O., Rabson A.S., Rosen S.W.
Ectopic and eutopic secretion of chorionic gonadotropin and its subunits in vitro: comparison of clonal strains from carcinomas of lung and placenta.
J. Natl. Cancer Inst. 56:911-917(1976)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

Rousset M., Zweibaum A., Fogh J.
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

Dracopoli N.C., Fogh J.
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=7937597; DOI=10.1016/0143-4004(94)90008-6
Grummer R., Hohn H.-P., Mareel M.M., Denker H.-W.
Adhesion and invasion of three human choriocarcinoma cell lines into human endometrium in a three-dimensional organ culture system.
Placenta 15:411-429(1994)

Brown A.D., Lopez-Terrada D., Denny C., Lee K.A.W.
Promoters containing ATF-binding sites are de-regulated in cells that express the EWS/ATF1 oncogene.
Oncogene 10:1749-1756(1995)

PubMed=11994546; DOI=10.1093/molehr/8.5.485
Blanchon L., Sauvant P., Bavik C., Gallot D., Charbonne F., Alexandre-Gouabau M.-C., Lemery D., Jacquetin B., Dastugue B., Ward S., Sapin V.
Human choriocarcinoma cell line JEG-3 produces and secretes active retinoids from retinol.
Mol. Hum. Reprod. 8:485-493(2002)

PubMed=12966428; DOI=10.1038/sj.bjc.6601212
Li K.K.C., Goodall J., Goding C.R., Liao S.-K., Wang C.-H., Lin Y.-C., Hiraga H., Nojima T., Nagashima K., Schaefer K.-L., Lee K.A.W.
The melanocyte inducing factor MITF is stably expressed in cell lines from human clear cell sarcoma.
Br. J. Cancer 89:1072-1078(2003)

PubMed=16797695; DOI=10.1016/j.placenta.2006.05.001
Burleigh D.W., Kendziorski C.M., Choi Y.J., Grindle K.M., Grendell R.L., Magness R.R., Golos T.G.
Microarray analysis of BeWo and JEG3 trophoblast cell lines: identification of differentially expressed transcripts.
Placenta 28:383-389(2007)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cell line collections AddexBio; C0030003/4940
BCRC; 60428
BCRJ; 0123
CLS; 300222/p698_JEG-3
ECACC; 92120308
KCLB; 30036
NCBI_Iran; C544
Cell line databases/resources CLDB; cl2935
CLDB; cl2936
CCRID; 3111C0001CCC000071
Cosmic-CLP; 907176
GDSC; 907176
TOKU-E; 2070
Ontologies BTO; BTO:0002269
CLO; CLO_0007017
EFO; EFO_0002066
MCCL; MCC:0000257
Biological sample resources BioSample; SAMN01821538
BioSample; SAMN01821638
Chemistry resources ChEMBL-Cells; CHEMBL3308202
ChEMBL-Targets; CHEMBL2366348
Gene expression databases GEO; GSM48266
GEO; GSM48267
GEO; GSM48268
GEO; GSM1669948
Polymorphism and mutation databases Cosmic; 683654
Cosmic; 907176
Cosmic; 1312288
Cosmic; 2077192