Cell line name | Jurkat E6.1 | ||||||||||||||||||||||||||||||||||||
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Synonyms | JurkatE6-1; Jurkat E6-1; Jurkat, Clone E6-1; Jurkat Clone E6-1; Jurkat (clone E6-1); JURKAT E-6.1; JURKAT E-61; Jurkat-E6; Jurkat E6; J.E6-1; E6-1 | ||||||||||||||||||||||||||||||||||||
Accession | CVCL_0367 | ||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: Jurkat E6.1 (RRID:CVCL_0367) | ||||||||||||||||||||||||||||||||||||
Comments | Group: Space-flown cell line (cellonaut). Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981). Doubling time: 20.7 +- 2.2 hours (PubMed=10468210). Omics: Cell surface proteome. Omics: Deep phosphoproteome analysis. Omics: Deep quantitative phosphoproteome analysis. Omics: Deep RNAseq analysis. Omics: Genome sequenced. Omics: H3K4me3 ChIP-seq epigenome analysis. Omics: SNP array analysis. Anecdotal: Have been flown in space on shuttle flights STS-76, STS-80 and STS-95 to study apoptosis and cytoskeleton modifications (PubMed=9707173; PubMed=10832058; PubMed=11481229; PubMed=11669127). Derived from sampling site: Peripheral blood. | ||||||||||||||||||||||||||||||||||||
Sequence variations | Heterozygous for BAX p.Glu41Argfs*19 (c.121delG) (ClinVar=VCV000009512) (PubMed=29739316).Heterozygous for BAX p.Glu41Glyfs*33 (c.121dupG) (ClinVar=VCV000009511) (PubMed=29739316).Heterozygous for FBXW7 p.Arg505Cys (c.1513C>T) (ClinVar=VCV000069961) (from parent cell line).Heterozygous for INPP5D p.Gln345Ter (c.1033C>T) (PubMed=29739316).Heterozygous for INPP5D c.1097+1065_1097+1112del47 (PubMed=29739316).Homozygous for MSH2 p.Arg711Ter (c.2131C>T) (ClinVar=VCV000090903) (PubMed=29739316).Homozygous for MSH6 p.Phe1088Serfs*2 (c.3261delC) (ClinVar=VCV000089363) (from parent cell line).Heterozygous for SYK p.Met34Hisfs*3 (c.98_99insG) (PubMed=7592872; PubMed=29739316).Heterozygous for TP53 p.Arg196Ter (c.586C>T) (ClinVar=VCV000043589) (PubMed=29739316). | ||||||||||||||||||||||||||||||||||||
Disease | Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) | ||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Hierarchy | Parent: CVCL_0065 (Jurkat) Children:
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Sex of cell | Male | ||||||||||||||||||||||||||||||||||||
Age at sampling | 14Y | ||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||
STR profile | Source(s): ATCC; CCRID; CLS; DOI=10.1101/2020.07.06.190801; ECACC; KCLB; PubMed=11416159; PubMed=25877200 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||
Web pages | http://www.nibsc.org/Default.aspx?pageid=597&id=0027&theme=default http://www.cellresource.cn/fdetail.aspx?id=75 http://www.cellresource.cn/fdetail.aspx?id=421 http://www.cellresource.cn/fdetail.aspx?id=691 http://www.cellresource.cn/fdetail.aspx?id=848 http://www.cellresource.cn/fdetail.aspx?id=1537 | ||||||||||||||||||||||||||||||||||||
Publications | PubMed=8316623; DOI=10.2307/3578190 PubMed=7592872; DOI=10.1074/jbc.270.44.26533 PubMed=9707173; DOI=10.1096/fasebj.12.11.1007 PubMed=10468210; DOI=10.1016/S0891-5849(99)00074-X PubMed=10832058; DOI=10.1016/S0531-5565(00)00090-5 PubMed=11481229; DOI=10.1096/fj.00-0820fje PubMed=11669127; DOI=10.1016/S0094-5765(01)00116-3 PubMed=15472075; DOI=10.1126/science.1102160 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 PubMed=23933134; DOI=10.1016/j.jprot.2013.07.019 PubMed=25485619; DOI=10.1038/nbt.3080 PubMed=25894527; DOI=10.1371/journal.pone.0121314 PubMed=26546556; DOI=10.1016/j.jprot.2015.10.029 PubMed=28464451; DOI=10.1002/pmic.201600470 PubMed=29739316; DOI=10.1186/s12864-018-4718-6 DOI=10.1101/2020.07.06.190801 | ||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||
Cell line collections | ATCC; TIB-152
BCRC; 60424 BCRJ; 0125 CCTCC; GDC0094 CLS; 300223/p849_Jurkat_E61 ECACC; 88042803 KCB; KCB 94008YJ KCLB; 40152 NCBI_Iran; C121 NIH-ARP; 177-450 | ||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLDB; cl2962
CCRID; 3111C0001CCC000075 CCRID; 3111C0001CCC000348 CCRID; 3111C0002000000049 CCRID; 3131C0001000700123 CCRID; 3142C0001000000080 Cell_Model_Passport; SIDM01244 LINCS_LDP; LCL-1030 TOKU-E; 2081 | ||||||||||||||||||||||||||||||||||||
Ontologies | BTO; BTO:0001948
CLO; CLO_0007045 MCCL; MCC:0000260 | ||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN03472194
ENCODE; ENCBS407ENC ENCODE; ENCBS429ENC ENCODE; ENCBS550BVM ENCODE; ENCBS551ZKL ENCODE; ENCBS606GXJ ENCODE; ENCBS661UFZ ENCODE; ENCBS732UVO ENCODE; ENCBS755XWL | ||||||||||||||||||||||||||||||||||||
Chemistry resources | PharmacoDB; Jurkat_Clone_E61_713_2019 | ||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-2706
GEO; GSE101101 GEO; GSM472928 GEO; GSM510511 GEO; GSM827151 GEO; GSM923424 GEO; GSM945267 GEO; GSM945268 | ||||||||||||||||||||||||||||||||||||
Metabolomic databases | MetaboLights; MTBLS789 | ||||||||||||||||||||||||||||||||||||
Other | Wikidata; Q54899132 | ||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 913419
Progenetix; CVCL_0367 | ||||||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PRD000345
PRIDE; PXD000148 PRIDE; PXD000589 PRIDE; PXD002871 PRIDE; PXD004415 PRIDE; PXD010176 | ||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||||||||||||||||||||
Version number | 32 |