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Cellosaurus KATO III (CVCL_0371)

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Cell line name KATO III
Synonyms Kato III; Kato-III; KATO-III; KATOIII; KatoIII; KATO 3; JTC-28; Japanese Tissue Culture-28
Accession CVCL_0371
Resource Identification Initiative To cite this cell line use: KATO III (RRID:CVCL_0371)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: FGFR genetic alteration cell panel (ATCC TCP-1034).
Part of: MD Anderson Cell Lines Project.
Doubling time: 36 hours (PubMed=209229); 32-34 hours (PubMed=3962675).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: ChIP-seq GATA4 analysis.
Omics: ChIP-seq GATA6 analysis.
Omics: ChIP-seq KLF5 analysis.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for TP53 deletion (PubMed=1370612; PubMed=1933850).
HLA typing Source: PubMed=9023415
Class I
HLA-AA*02,24:02
HLA-BB*15:01,46:01
HLA-CC*01:02,03:03

Source: PubMed=25960936
Class I
HLA-AA*02:07,02:07
HLA-BB*15:01,46:01
HLA-CC*01:02,01:02
Class II
HLA-DQDQA1*01:02,01:02
DQB1*06:02,06:02
HLA-DRDRB1*08:03,15:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.78
Native American0
East Asian, North78.55
East Asian, South19.58
South Asian1.02
European, North0.06
European, South0
Disease Down syndrome (NCIt: C2993)
Gastric signet ring cell adenocarcinoma (NCIt: C5250)
Down syndrome (ORDO: Orphanet_870)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_M882 (KATO II)
Children:
CVCL_M251 (KATO III/CMV-Luc)CVCL_VL11 (TU-KATO-III)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
STR profile Source(s): AddexBio; ATCC; CLS; ECACC; JCRB; KCLB; PubMed=25877200; RCB; TKG

Markers:
AmelogeninX
CSF1PO7,11
D3S135815,16
D5S81810,11
D7S8208,12 (AddexBio; ATCC; CLS; Cosmic-CLP; ECACC; JCRB; KCLB; RCB; TKG)
12 (PubMed=25877200)
D8S117913,14
D13S3178,12
D16S53910,12
D18S5112
D21S1130,31
FGA23,24 (CLS; KCLB)
23,25 (PubMed=25877200)
Penta D13,14
Penta E13,18,19
TH017,9
TPOX11
vWA14,16

Run an STR similarity search on this cell line
Web pages http://tcpaportal.org/mclp/
http://www.cellresource.cn/fdetail.aspx?id=1595
Publications

PubMed=209229
Sekiguchi M., Sakakibara K., Fujii G.
Establishment of cultured cell lines derived from a human gastric carcinoma.
Jpn. J. Exp. Med. 48:61-68(1978)

PubMed=6862145; DOI=10.20772/cancersci1959.74.2_240
Naito S., Inoue S., Kinjo M., Tanaka K.
Thromboplastic and fibrinolytic activities of cultured human gastric cancer cell lines.
Gann 74:240-247(1983)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3962675; DOI=10.1111/j.1440-1827.1986.tb01461.x
Motoyama T., Hojo H., Watanabe H.
Comparison of seven cell lines derived from human gastric carcinomas.
Acta Pathol. Jpn. 36:65-83(1986)

DOI=10.2198/sbk.34.289
Mizusawa H.
Operation of the JCRB cell bank and isoenzyme.
Seibutsu Butsuri Kagaku 34:289-292(1990)

PubMed=1778766; DOI=10.1111/j.1349-7006.1991.tb01816.x
Takeshima E., Hamaguchi M., Watanabe T., Akiyama S., Kataoka M., Ohnishi Y., Xiao H.Y., Nagai Y., Takagi H.
Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.
Jpn. J. Cancer Res. 82:1428-1435(1991)

PubMed=1933850
Yamada Y., Yoshida T., Hayashi K., Sekiya T., Yokota J., Hirohashi S., Nakatani K., Nakano H., Sugimura T., Terada M.
p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases.
Cancer Res. 51:5800-5805(1991)

PubMed=1370612; DOI=10.1016/S0006-291X(05)80133-0
Matozaki T., Sakamoto C., Matsuda K., Suzuki T., Konda Y., Nakano O., Wada K., Uchida T., Nishisaki H., Nagao M., Kasuga M.
Missense mutations and a deletion of the p53 gene in human gastric cancer.
Biochem. Biophys. Res. Commun. 182:215-223(1992)

DOI=10.1016/B978-0-12-333530-2.50014-9
Sekiguchi M., Suzuki T.
Gastric tumor cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York (1994)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=9247707; DOI=10.1080/15216549700202901
Hatakeyama S., Gao Y.-H., Ohara-Nemoto Y., Kataoka H., Satoh M.
Expression of bone morphogenetic proteins of human neoplastic epithelial cells.
Biochem. Mol. Biol. Int. 42:497-505(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=11107048; DOI=10.1046/j.1440-1827.2000.01117.x
Yokozaki H.
Molecular characteristics of eight gastric cancer cell lines established in Japan.
Pathol. Int. 50:767-777(2000)

PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x
Takada H., Imoto I., Tsuda H., Sonoda I., Ichikura T., Mochizuki H., Okanoue T., Inazawa J.
Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.
Cancer Sci. 96:100-110(2005)

PubMed=17505008; DOI=10.1158/1078-0432.CCR-06-2743
Takeda M., Arao T., Yokote H., Komatsu T., Yanagihara K., Sasaki H., Yamada Y., Tamura T., Fukuoka K., Kimura H., Saijo N., Nishio K.
AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor.
Clin. Cancer Res. 13:3051-3057(2007)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24807215; DOI=10.1038/ncomms4830
Liu J., McCleland M., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H., Wan Y., Chopra V., Yaylaoglu M.B., Yuan W., Ha C., Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R., Zhang Z.
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Nat. Commun. 5:3830-3830(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:E954893-E954893(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E., Schweppe D.K., Jedrychowski M., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

Cross-references
Cell line collections AddexBio; C0023001/53
ATCC; HTB-103
BCRC; 60200
BCRJ; 0318
CCTCC; GDC0253
CLS; 300381/p610_KATO-III
ECACC; 86093004
IZSLER; BS TCL 151
JCRB; JCRB0611
JCRB; NIHS0052 - Discontinued
KCB; KCB 2014045YJ
KCLB; 30103
NCBI_Iran; C640
RCB; RCB2088
TKG; TKG 0213
Cell line databases/resources CLDB; cl5214
CLDB; cl3000
CCLE; KATOIII_STOMACH
CCRID; 3131C0001001200014
Cell_Model_Passport; SIDM00687
CGH-DB; 122-1
CGH-DB; 9024-4
Cosmic-CLP; 907276
DepMap; ACH-000793
IGRhCellID; KATOIII
LINCS_HMS; 50022
LINCS_LDP; LCL-2003
Ontologies BTO; BTO:0001092
CLO; CLO_0007073
CLO; CLO_0050790
EFO; EFO_0002217
MCCL; MCC:0000266
Biological sample resources BioSample; SAMN01821574
BioSample; SAMN01821690
BioSample; SAMN03471089
BioSample; SAMN03473264
BioSample; SAMN10988331
Chemistry resources ChEMBL-Cells; CHEMBL3308432
ChEMBL-Targets; CHEMBL612700
GDSC; 907276
PharmacoDB; KATOIII_737_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM267419
GEO; GSM267426
GEO; GSM267433
GEO; GSM267440
GEO; GSM552362
GEO; GSM562404
GEO; GSM827547
GEO; GSM828835
GEO; GSM844573
GEO; GSM887200
GEO; GSM888273
GEO; GSM1237676
GEO; GSM1237701
GEO; GSM1250898
GEO; GSM1250899
GEO; GSM1250900
GEO; GSM1250901
GEO; GSM1374593
GEO; GSM1374594
GEO; GSM1669980
Other Wikidata; Q54899539
Polymorphism and mutation databases Cosmic; 685595
Cosmic; 687555
Cosmic; 755614
Cosmic; 801336
Cosmic; 848150
Cosmic; 848375
Cosmic; 877044
Cosmic; 887248
Cosmic; 888823
Cosmic; 889107
Cosmic; 907276
Cosmic; 922690
Cosmic; 926118
Cosmic; 968350
Cosmic; 1001657
Cosmic; 1067210
Cosmic; 1090464
Cosmic; 1187279
Cosmic; 1223583
Cosmic; 1518254
Cosmic; 1571766
Cosmic; 1627262
Cosmic; 1890472
Cosmic; 2009529
Cosmic; 2036664
Cosmic; 2069771
Cosmic; 2484964
IARC_TP53; 21648
LiGeA; CCLE_710
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number34