Cellosaurus KG-1 (CVCL_0374)

Cell line name KG-1
Synonyms KG1
Accession CVCL_0374
Resource Identification Initiative To cite this cell line use: KG-1 (RRID:CVCL_0374)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: FGFR genetic alteration cell panel (ATCC TCP-1034).
Part of: MD Anderson Cell Lines Project.
Doubling time: ~38 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Bone marrow.
Disease Adult acute myeloid leukemia (NCIt: C9154)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1824 (KG-1a)CVCL_5301 (KMT-2)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; DSMZ; ECACC; JCRB; KCLB; PubMed=17254797; PubMed=25877200; RCB

Markers:
AmelogeninX,Y
CSF1PO7
D13S31711,12
D16S53910,11
D18S5110,18 (PubMed=17254797)
10.2,18 (PubMed=25877200)
D21S1128,29
D3S135815,16
D5S81813
D7S8208,10
D8S117913,14
FGA22
Penta D8,9
Penta E7,13
TH017,8
TPOX7,9
vWA14,19
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=KG-1
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/k/cell-lines-detail-169.html
http://tcpaportal.org/mclp/
Publications

PubMed=306682; DOI=10.1126/science.306682
Koeffler H.P., Golde D.W.
Acute myelogenous leukemia: a human cell line responsive to colony-stimulating activity.
Science 200:1153-1154(1978)

PubMed=6996765
Koeffler H.P., Golde D.W.
Human myeloid leukemia cell lines: a review.
Blood 56:344-350(1980)

PubMed=6582512; DOI=10.1073/pnas.81.2.568
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=3856862; DOI=10.1073/pnas.82.6.1810
Konopka J.B., Watanabe S.M., Singer J.W., Collins S.J., Witte O.N.
Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.
Proc. Natl. Acad. Sci. U.S.A. 82:1810-1814(1985)

PubMed=3094604
Furley A.J.W., Reeves B.R., Mizutani S., Altass L.J., Watt S.M., Jacob M.C., van den Elsen P., Terhorst C., Greaves M.F.
Divergent molecular phenotypes of KG1 and KG1a myeloid cell lines.
Blood 68:1101-1107(1986)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=11021758; DOI=10.1038/sj.leu.2401891
Majka M., Rozmyslowicz T., Honczarenko M., Ratajczak J., Wasik M.A., Gaulton G.N., Ratajczak M.Z.
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Leukemia 14:1821-1832(2000)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Azari S., Ahmadi N., Tehrani M.J., Shokri F.
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23955599; DOI=10.1038/ng.2731
Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; CCL-246
ATCC; CRL-8031
BCRC; 60158
BCRJ; 0132
DSMZ; ACC-14
ECACC; 86111306
IZSLER; BS TCL 190
JCRB; JCRB0065
JCRB; JCRB9051
KCB; KCB 200552YJ
KCLB; 10246
NCBI_Iran; C119
RCB; RCB1166
Cell line databases/resources CLDB; cl3022
CLDB; cl3023
CLDB; cl3024
CLDB; cl3025
CCLE; KG1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
CCRID; 3131C0001000700105
CCRID; 3142C0001000000094
Cosmic-CLP; 907278
GDSC; 907278
IGRhCellID; KG1
LINCS_LDP; LCL-1056
Lonza; 746
Ontologies BTO; BTO:0000670
CLO; CLO_0007093
CLO; CLO_0007094
CLO; CLO_0051560
EFO; EFO_0002218
MCCL; MCC:0000269
Biological sample resources BioSample; SAMN01821643
BioSample; SAMN03473103
Chemistry resources ChEMBL-Cells; CHEMBL3307794
ChEMBL-Targets; CHEMBL612264
Gene expression databases GEO; GSM236787
GEO; GSM236823
GEO; GSM887208
GEO; GSM888281
GEO; GSM1374597
GEO; GSM1446744
GEO; GSM1669984
Polymorphism and mutation databases Cosmic; 683545
Cosmic; 717682
Cosmic; 787443
Cosmic; 851998
Cosmic; 907278
Cosmic; 919118
Cosmic; 924047
Cosmic; 975261
Cosmic; 981581
Cosmic; 985581
Cosmic; 996311
Cosmic; 998743
Cosmic; 999726
Cosmic; 1012078
Cosmic; 1019831
Cosmic; 1037660
Cosmic; 1070689
Cosmic; 1078730
Cosmic; 1107180
Cosmic; 1127253
Cosmic; 1150903
Cosmic; 1176582
Cosmic; 1181606
Cosmic; 1197928
Cosmic; 1281321
Cosmic; 1308223
Cosmic; 1523823
Cosmic; 1524832
Cosmic; 1582389
Cosmic; 1623637
Cosmic; 2060796
Cosmic; 2089672
Cosmic; 2131541
Cosmic; 2306212