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Cellosaurus KGN (CVCL_0375)

[Text version]

Cell line name KGN
Accession CVCL_0375
Resource Identification Initiative To cite this cell line use: KGN (RRID:CVCL_0375)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 46.4 hours (PubMed=11145608).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Ovary; ovarian follicle; granulosa cell layer.
Sequence variations Heterozygous for FOXL2 p.Cys134Trp (c.402C>G) (ClinVar=VCV000376348) (PubMed=19956657; PubMed=20098707).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.09
East Asian, North73.92
East Asian, South24.17
South Asian1.82
European, North0
European, South0
Disease Ovarian granulosa cell tumor (NCIt: C6261)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; RCB


Run an STR similarity search on this cell line

PubMed=11145608; DOI=10.1210/endo.142.1.7862
Nishi Y., Yanase T., Mu Y., Oba K., Ichino I., Saito M., Nomura M., Mukasa C., Okabe T., Goto K., Takayanagi R., Kashimura Y., Haji M., Nawata H.
Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor.
Endocrinology 142:437-445(2001)

PubMed=15541573; DOI=10.1016/j.mce.2004.04.018
Havelock J.C., Rainey W.E., Carr B.R.
Ovarian granulosa cell lines.
Mol. Cell. Endocrinol. 228:67-78(2004)

PubMed=18980698; DOI=10.1186/1471-2407-8-319
Imai M., Muraki M., Takamatsu K., Saito H., Seiki M., Takahashi Y.
Spontaneous transformation of human granulosa cell tumours into an aggressive phenotype: a metastasis model cell line.
BMC Cancer 8:319-319(2008)

PubMed=19956657; DOI=10.1371/journal.pone.0007988
Schrader K.A., Gorbatcheva B., Senz J., Heravi-Moussavi A., Melnyk N., Salamanca C., Maines-Bandiera S., Cooke S.L., Leung P., Brenton J.D., Gilks C.B., Monahan J., Huntsman D.G.
The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors.
PLoS ONE 4:E7988-E7988(2009)

PubMed=20098707; DOI=10.1371/journal.pone.0008789
Benayoun B.A., Caburet S., Dipietromaria A., Georges A., D'Haene B., Pandaranayaka P.J., L'Hote D., Todeschini A.-L., Krishnaswamy S., Fellous M., De Baere E., Veitia R.A.
Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G).
PLoS ONE 5:E8789-E8789(2010)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections RCB; RCB1154
Cell line databases/resources CCLE; KGN_OVARY
Cell_Model_Passport; SIDM00302
Cosmic-CLP; 924186
DepMap; ACH-002149
Ontologies BTO; BTO:0005671
CLO; CLO_0051454
MCCL; MCC:0000270
Biological sample resources BioSample; SAMN03472163
Chemistry resources ChEMBL-Cells; CHEMBL3308155
ChEMBL-Targets; CHEMBL2366154
GDSC; 924186
PharmacoDB; KGN_746_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669985
Other Wikidata; Q54899838
Polymorphism and mutation databases Cosmic; 924186
Cosmic; 1149409
Cosmic; 1213591
Cosmic; 1305320
Cosmic; 1312287
Cosmic; 1429993
Cosmic; 2368538
Cosmic; 2697832
Entry history
Entry creation04-Apr-2012
Last entry update29-Oct-2020
Version number28