Cellosaurus KGN (CVCL_0375)

Cell line name KGN
Accession CVCL_0375
Resource Identification Initiative To cite this cell line use: KGN (RRID:CVCL_0375)
Comments Part of: COSMIC cell lines project.
Doubling time: 46.4 hours (PubMed=11145608).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Sequence variations Heterozygous for FOXL2 p.Cys134Trp (PubMed=20098707).
Disease Ovarian granulosa cell tumor (NCIt: C6261)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; RCB


PubMed=11145608; DOI=10.1210/endo.142.1.7862
Nishi Y., Yanase T., Mu Y., Oba K., Ichino I., Saito M., Nomura M., Mukasa C., Okabe T., Goto K., Takayanagi R., Kashimura Y., Haji M., Nawata H.
Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor.
Endocrinology 142:437-445(2001)

PubMed=15541573; DOI=10.1016/j.mce.2004.04.018
Havelock J.C., Rainey W.E., Carr B.R.
Ovarian granulosa cell lines.
Mol. Cell. Endocrinol. 228:67-78(2004)

PubMed=18980698; DOI=10.1186/1471-2407-8-319
Imai M., Muraki M., Takamatsu K., Saito H., Seiki M., Takahashi Y.
Spontaneous transformation of human granulosa cell tumours into an aggressive phenotype: a metastasis model cell line.
BMC Cancer 8:319-319(2008)

PubMed=20098707; DOI=10.1371/journal.pone.0008789
Benayoun B.A., Caburet S., Dipietromaria A., Georges A., D'Haene B., Pandaranayaka P.J., L'Hote D., Todeschini A.-L., Krishnaswamy S., Fellous M., De Baere E., Veitia R.A.
Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G).
PLoS ONE 5:E8789-E8789(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cell line collections RCB; RCB1154
Cell line databases/resources Cosmic-CLP; 924186
GDSC; 924186
Ontologies BTO; BTO:0005671
CLO; CLO_0051454
MCCL; MCC:0000270
Biological sample resources BioSample; SAMN03472163
Chemistry resources ChEMBL-Cells; CHEMBL3308155
ChEMBL-Targets; CHEMBL2366154
Gene expression databases GEO; GSM1669985
Polymorphism and mutation databases Cosmic; 924186
Cosmic; 1149409
Cosmic; 1213591
Cosmic; 1305320
Cosmic; 1312287
Cosmic; 1429993
Cosmic; 2368538