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Cellosaurus Ku812 (CVCL_0379)

Cell line name Ku812
Synonyms KU812; KU-812; KU.812; KU 812
Accession CVCL_0379
Resource Identification Initiative To cite this cell line use: Ku812 (RRID:CVCL_0379)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~80-100 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_0615 (Ku812E)CVCL_0616 (Ku812F)
Sex of cell Male
Age at sampling 38Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; DSMZ; ECACC; JCRB; PubMed=11416159; PubMed=25877200; RCB

Markers:
AmelogeninX,Y
CSF1PO12,13
D13S3178
D16S5399
D18S5113
D21S1130,31.2
D3S135815
D5S81810
D7S82012
D8S117911,15
FGA22,24
Penta D12
Penta E5,19
TH019
TPOX12
vWA15
Publications

PubMed=3858609; DOI=10.1016/0145-2126(85)90060-8
Kishi K.
A new leukemia cell line with Philadelphia chromosome characterized as basophil precursors.
Leuk. Res. 9:381-390(1985)

PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9
Keating A.
Ph positive CML cell lines.
Baillieres Clin. Haematol. 1:1021-1029(1987)

PubMed=2540861
Nakazawa M., Mitjavila M.-T., Debili N., Casadevall N., Mayeux P., Rouyer-Fessard P., Dubart A., Romeo P.-H., Beuzard Y., Kishi K., Breton-Gorius J., Vainchenker W.
KU 812: a pluripotent human cell line with spontaneous erythroid terminal maturation.
Blood 73:2003-2013(1989)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9644295; DOI=10.1159/000040837
Kaneko H., Horiike S., Sasai Y., Iwai T., Nakao M., Yokota S., Taniwaki M., Kashima K., Misawa S.
Rare alteration of genomic structure or expression of the DPC4 gene in myelogenous leukemias.
Acta Haematol. 99:187-190(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; CRL-2099
BCRC; 60502
BCRJ; 0261
DSMZ; ACC-378
ECACC; 90071807
JCRB; IFO50363
JCRB; JCRB0104
RCB; RCB0495
Cell line databases/resources CLDB; cl3070
CCLE; KU812_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
CGH-DB; 9211-4
Cosmic-CLP; 907311
GDSC; 907311
IGRhCellID; KU812
LINCS_LDP; LCL-1106
Lonza; 1207
Ontologies BTO; BTO:0000732
CLO; CLO_0007124
CLO; CLO_0007125
CLO; CLO_0050989
EFO; EFO_0002222
MCCL; MCC:0000274
Biological sample resources BioSample; SAMN01821693
BioSample; SAMN01821733
BioSample; SAMN03472893
Chemistry resources ChEMBL-Cells; CHEMBL3308504
ChEMBL-Targets; CHEMBL613997
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM887244
GEO; GSM888318
GEO; GSM1374606
GEO; GSM1670011
Other Wikidata; Q54900693
Polymorphism and mutation databases Cosmic; 787498
Cosmic; 907311
Cosmic; 919119
Cosmic; 922163
Cosmic; 924052
Cosmic; 949096
Cosmic; 991560
Cosmic; 999778
Cosmic; 1012080
Cosmic; 1026568
Cosmic; 1067444
Cosmic; 1078716
Cosmic; 1519164
Cosmic; 2009518