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Cellosaurus KYN-2 (CVCL_0381)

[Text version]
Cell line name KYN-2
Synonyms KYN2
Accession CVCL_0381
Resource Identification Initiative To cite this cell line use: KYN-2 (RRID:CVCL_0381)
Comments Population: Japanese.
Doubling time: 28 hours (Note=In DMEMA + 10% FBS), 68 hours (Note=In HB101), 42 hours (Note=In CDM) (PubMed=2847482).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
HLA typing Source: PubMed=9178645
Class I
HLA-AA*24:02,24:02
HLA-BB*52:01
HLA-CC*12:02
Class II
HLA-DQDQA1*01:02,03:01
DQB1*04:01,05:02
HLA-DRDRB1*04:05,16:02
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
Publications

PubMed=2847482; DOI=10.1111/j.1440-1827.1988.tb02368.x
Yano H., Maruiwa M., Murakami T., Fukuda K., Ito Y., Sugihara S., Kojiro M.
A new human pleomorphic hepatocellular carcinoma cell line, KYN-2.
Acta Pathol. Jpn. 38:953-966(1988)

PubMed=7537711; DOI=10.1002/hep.1840210510
Haramaki M., Yano H., Fukuda K., Momosaki S., Ogasawara S., Kojiro M.
Expression of CD44 in human hepatocellular carcinoma cell lines.
Hepatology 21:1276-1284(1995)

PubMed=8738480; DOI=10.1007/BF00143361
Abid A., Sabolovic N., Magdalou J.
Inducibility of ethoxyresorufin deethylase and UDP-glucuronosyltransferase activities in two human hepatocarcinoma cell lines KYN-2 and Mz-Hep-1.
Cell Biol. Toxicol. 12:115-123(1996)

PubMed=9178645; DOI=10.1006/cimm.1997.1108
Nakao M., Sata M., Saitsu H., Yutani S., Kawamoto M., Kojiro M., Itoh K.
CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular carcinoma.
Cell. Immunol. 177:176-181(1997)

PubMed=10347112; DOI=10.1002/hep.510290624
Yano H., Iemura A., Haramaki M., Ogasawara S., Takayama A., Akiba J., Kojiro M.
Interferon alfa receptor expression and growth inhibition by interferon alfa in human liver cancer cell lines.
Hepatology 29:1708-1717(1999)

PubMed=27329724; DOI=10.18632/oncotarget.10161
Watari K., Nishitani A., Shibata T., Noda M., Kawahara A., Akiba J., Murakami Y., Yano H., Kuwano M., Ono M.
Phosphorylation of mTOR Ser2481 is a key target limiting the efficacy of rapalogs for treating hepatocellular carcinoma.
Oncotarget 7:47403-47417(2016)

Cross-references
Cell line databases/resources MCCL; MCC:0000276
Encyclopedic resources Wikidata; Q54900790
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number14