ID   LA-N-5
AC   CVCL_0389
SY   LAN-5; Lan-5; LAN5; Lan5; NBLAN5T
DR   BTO; BTO:0000935
DR   CLO; CLO_0007242
DR   CLO; CLO_0050264
DR   MCCL; MCC:0000284
DR   CLDB; cl3170
DR   CLDB; cl3171
DR   ArrayExpress; E-MTAB-783
DR   BioSample; SAMN03472329
DR   BioSample; SAMN03473428
DR   cancercelllines; CVCL_0389
DR   Cosmic; 801742
DR   Cosmic; 920242
DR   Cosmic; 923828
DR   Cosmic; 930066
DR   Cosmic; 947705
DR   Cosmic; 1037345
DR   Cosmic; 1099142
DR   Cosmic; 1109122
DR   Cosmic; 1153783
DR   Cosmic; 1161992
DR   Cosmic; 1167989
DR   Cosmic; 1212538
DR   Cosmic; 1518068
DR   Cosmic; 1526629
DR   Cosmic; 1890201
DR   Cosmic; 2131580
DR   Cosmic; 2239462
DR   Cosmic; 2301576
DR   Cosmic; 2393636
DR   DSMZ; ACC-673
DR   DSMZCellDive; ACC-673
DR   GEO; GSM313804
DR   GEO; GSM333799
DR   GEO; GSM692871
DR   GEO; GSM2371239
DR   GEO; GSM2394369
DR   GEO; GSM4104579
DR   GEO; GSM4104580
DR   GEO; GSM4104628
DR   GEO; GSM4104629
DR   GEO; GSM4105313
DR   GEO; GSM4105314
DR   GEO; GSM4105315
DR   GEO; GSM4105316
DR   GEO; GSM4105317
DR   IARC_TP53; 21459
DR   ICLC; HTL96022
DR   LINCS_LDP; LCL-1987
DR   Lonza; 1157
DR   NCBI_Iran; C613
DR   Progenetix; CVCL_0389
DR   RCB; RCB0485
DR   Wikidata; Q54901878
RX   DOI=10.1007/0-306-46872-7_2;
RX   DOI=10.1016/B978-0-12-333530-2.50006-X;
RX   PubMed=6172518;
RX   PubMed=15892104;
RX   PubMed=18082704;
RX   PubMed=18724359;
RX   PubMed=18923524;
RX   PubMed=20164919;
RX   PubMed=20655465;
RX   PubMed=22213050;
RX   PubMed=23202128;
RX   PubMed=24466371;
RX   PubMed=24792489;
RX   PubMed=28350380;
WW   http://www.cccells.org/dl/NB_Data_Sheets/LA-N-5_Cell_Line_Data_Sheet_COGcell_org.pdf
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/l/cell-lines-detail-481.html
CC   Doubling time: ~100 hours (DSMZ=ACC-673).
CC   Sequence variation: Mutation; HGNC; 427; ALK; Simple; p.Arg1275Gln (c.3824G>A); ClinVar=VCV000018083; Zygosity=Unspecified (PubMed=18724359; PubMed=28350380).
CC   Omics: Array-based CGH.
CC   Omics: Chromatin accessibility by ATAC-seq.
CC   Omics: H3K27ac ChIP-seq epigenome analysis.
CC   Omics: H3K27me3 ChIP-seq epigenome analysis.
CC   Omics: H3K4me1 ChIP-seq epigenome analysis.
CC   Omics: H3K4me3 ChIP-seq epigenome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Miscellaneous: On the basis that LA-350 (Cellosaurus=CVCL_AR50) and LA-N-5 are both established by Seeger R.C., that they share identical STR profiles and that LA-350 is said to originate from a patient suffering from neuroblastoma we have annotated them as being autologous cell lines.
CC   Misspelling: LAN-3; Cosmic=920242.
CC   Discontinued: ICLC; HTL96022; true.
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): COG; DSMZ; RCB
ST   Amelogenin: X,Y
ST   CSF1PO: 10 (COG)
ST   CSF1PO: 10,11 (DSMZ; RCB)
ST   D13S317: 9,12
ST   D16S539: 9 (DSMZ)
ST   D16S539: 9,12 (COG; RCB)
ST   D18S51: 17,22
ST   D19S433: 13,15
ST   D21S11: 29,31
ST   D2S1338: 19,25
ST   D3S1358: 15,16
ST   D5S818: 11
ST   D7S820: 10
ST   D8S1179: 11,13
ST   FGA: 21,27
ST   Penta D: 11,13
ST   Penta E: 11,12
ST   TH01: 6,9.3
ST   TPOX: 8
ST   vWA: 15,16
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_AR50 ! LA-350
SX   Male
AG   4M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 35
//
RX   DOI=10.1007/0-306-46872-7_2;
RA   Thiele C.J.;
RT   "Neuroblastoma.";
RL   (In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999).
//
RX   DOI=10.1016/B978-0-12-333530-2.50006-X;
RA   Israel M.A., Thiele C.J.;
RT   "Tumor cell lines of the peripheral nervous system.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York (1994).
//
RX   PubMed=6172518; DOI=10.4049/jimmunol.128.2.983;
RA   Seeger R.C., Danon Y.L., Rayner S.A., Hoover F.;
RT   "Definition of a Thy-1 determinant on human neuroblastoma, glioma,
RT   sarcoma, and teratoma cells with a monoclonal antibody.";
RL   J. Immunol. 128:983-989(1982).
//
RX   PubMed=15892104; DOI=10.1002/gcc.20198;
RA   Mosse Y.P., Greshock J., Margolin A.A., Naylor T., Cole K., Khazi D.,
RA   Hii G., Winter C., Shahzad S., Asziz M.U., Biegel J.A., Weber B.L.,
RA   Maris J.M.;
RT   "High-resolution detection and mapping of genomic DNA alterations in
RT   neuroblastoma.";
RL   Genes Chromosomes Cancer 43:390-403(2005).
//
RX   PubMed=18082704; DOI=10.1016/j.jpedsurg.2007.08.026;
RA   Komuro H., Saihara R., Shinya M., Takita J., Kaneko S., Kaneko M.,
RA   Hayashi Y.;
RT   "Identification of side population cells (stem-like cell population)
RT   in pediatric solid tumor cell lines.";
RL   J. Pediatr. Surg. 42:2040-2045(2007).
//
RX   PubMed=18724359; DOI=10.1038/nature07261;
RA   Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A.,
RA   Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P.,
RA   Laureys G., Speleman F., Kim C., Hou C.-P., Hakonarson H., Torkamani A.,
RA   Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M.,
RA   Maris J.M.;
RT   "Identification of ALK as a major familial neuroblastoma
RT   predisposition gene.";
RL   Nature 455:930-935(2008).
//
RX   PubMed=18923524; DOI=10.1038/nature07399;
RA   Chen Y.-Y., Takita J., Choi Y.L., Kato M., Ohira M., Sanada M.,
RA   Wang L.-L., Soda M., Kikuchi A., Igarashi T., Nakagawara A.,
RA   Hayashi Y., Mano H., Ogawa S.;
RT   "Oncogenic mutations of ALK kinase in neuroblastoma.";
RL   Nature 455:971-974(2008).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20655465; DOI=10.1016/j.cell.2010.06.004;
RA   Holzel M., Huang S.-D., Koster J., Ora I., Lakeman A., Caron H.N.,
RA   Nijkamp W., Xie J., Callens T., Asgharzadeh S., Seeger R.C.,
RA   Messiaen L.M., Versteeg R., Bernards R.;
RT   "NF1 is a tumor suppressor in neuroblastoma that determines retinoic
RT   acid response and disease outcome.";
RL   Cell 142:218-229(2010).
//
RX   PubMed=22213050; DOI=10.1002/ijc.27415;
RA   Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J.,
RA   Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.;
RT   "PEA15 impairs cell migration and correlates with clinical features
RT   predicting good prognosis in neuroblastoma.";
RL   Int. J. Cancer 131:1556-1568(2012).
//
RX   PubMed=23202128; DOI=10.1038/ng.2493;
RA   Sausen M., Leary R.J., Jones S., Wu J., Reynolds C.P., Liu X.-Y.,
RA   Blackford A.L., Parmigiani G., Diaz L.A. Jr., Papadopoulos N.,
RA   Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.;
RT   "Integrated genomic analyses identify ARID1A and ARID1B alterations in
RT   the childhood cancer neuroblastoma.";
RL   Nat. Genet. 45:12-17(2013).
//
RX   PubMed=24466371; DOI=10.1593/tlo.13544;
RA   Loschmann N., Michaelis M., Rothweiler F., Zehner R., Cinatl J.,
RA   Voges Y., Sharifi M., Riecken K., Meyer J., von Deimling A.,
RA   Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.;
RT   "Testing of SNS-032 in a panel of human neuroblastoma cell lines with
RT   acquired resistance to a broad range of drugs.";
RL   Transl. Oncol. 6:685-696(2013).
//
RX   PubMed=24792489; DOI=10.1007/s11060-014-1456-8;
RA   Farooqi A.S., Dagg R.A., Choi L.M.R., Shay J.W., Reynolds C.P.,
RA   Lau L.M.S.;
RT   "Alternative lengthening of telomeres in neuroblastoma cell lines is
RT   associated with a lack of MYCN genomic amplification and with p53
RT   pathway aberrations.";
RL   J. Neurooncol. 119:17-26(2014).
//
RX   PubMed=28350380; DOI=10.1038/sdata.2017.33;
RA   Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L.,
RA   Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.;
RT   "Transcriptomic profiling of 39 commonly-used neuroblastoma cell
RT   lines.";
RL   Sci. Data 4:170033-170033(2017).
//