ID   LLC-PK1
AC   CVCL_0391
AS   CVCL_K238
SY   LLC-PK(1); LLC-PK-1; LLC PK-1; LLc-PK1; LLC PK1; LLCPK1; Lilly Laboratories Culture-Porcine Kidney 1
DR   BTO; BTO:0000760
DR   CLO; CLO_0007331
DR   MCCL; MCC:0000286
DR   CLDB; cl3221
DR   CLDB; cl5221
DR   ABM; T9045
DR   ATCC; CL-101
DR   ATCC; CRL-1392
DR   BCRC; 60080
DR   BCRJ; 0147
DR   CCRID; 1101SWI-PUMC000111
DR   CCRID; 4201SWI-CCTCC00612
DR   ChEMBL-Cells; CHEMBL3307655
DR   ChEMBL-Targets; CHEMBL614577
DR   CLS; 607264
DR   DSMZ; ACC-637
DR   DSMZCellDive; ACC-637
DR   ECACC; 86121112
DR   GEO; GSM4009059
DR   GEO; GSM4009060
DR   GEO; GSM4009061
DR   IZSLER; BS CL 111
DR   JCRB; JCRB0060
DR   Lonza; 844
DR   MeSH; D018374
DR   PRIDE; PXD007891
DR   PubChem_Cell_line; CVCL_0391
DR   TOKU-E; 2208
DR   Wikidata; Q28334936
RX   Patent=US3904480;
RX   PubMed=828141;
RX   PubMed=8097873;
RX   PubMed=14449902;
RX   PubMed=17389150;
RX   PubMed=19508353;
RX   PubMed=20555413;
RX   PubMed=33122286;
RX   PubMed=34737324;
WW   https://www.atcc.org/en/support/technical-support/faqs/atcc-cl-101-vs-atcc-cl-101-1
WW   https://micro.magnet.fsu.edu/primer/techniques/fluorescence/gallery/cells/llcpk1/llcpk1cells.html
WW   https://www.olympus-lifescience.com/de/microscope-resource/primer/techniques/fluorescence/gallery/cells/epithelialindex/
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/l/cell-lines-detail-150.html
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CL-101.
CC   Doubling time: ~24 hours (DSMZ=ACC-637).
CC   Omics: Transcriptome analysis by RNAseq.
CC   Discontinued: ATCC; CRL-1392; true.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
CC   Breed/subspecies: Hampshire.
OX   NCBI_TaxID=9823; ! Sus scrofa (Pig)
SX   Male
AG   3-4W
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 33
//
RX   Patent=US3904480;
RA   Hull R.N., Huseby R.M.;
RT   "Enhanced production of plasminogen activator.";
RL   Patent number US3904480, 09-Sep-1975.
//
RX   PubMed=828141; DOI=10.1007/BF02797469;
RA   Hull R.N., Cherry W.R., Weaver G.W.;
RT   "The origin and characteristics of a pig kidney cell strain, LLC-PK1.";
RL   In Vitro 12:670-677(1976).
//
RX   PubMed=8097873; DOI=10.1023/A:1018954204094;
RA   Hori R., Okuda M., Ohishi Y., Yasuhara M., Inui K.-i., Takano M.;
RT   "Decreased cellular toxicity of neomycin in a clonal cell line
RT   isolated from LLC-PK1.";
RL   Pharm. Res. 10:573-576(1993).
//
RX   PubMed=14449902;
RA   Hull R.N., Tritch O.J.;
RT   "Characterization of cell strains by viral susceptibility.";
RL   Natl. Cancer Inst. Monogr. 7:161-172(1962).
//
RX   PubMed=17389150; DOI=10.1016/j.cbpa.2007.02.005;
RA   Pine M.D., Greer K.A., Busbee D.L.;
RT   "Comparison of reactive oxygen scavenging systems between a cetacean
RT   (DKN1) and a porcine renal epithelial cell line (LLC-PK1).";
RL   Comp. Biochem. Physiol. 147A:550-555(2007).
//
RX   PubMed=19508353; DOI=10.1111/j.1744-313X.2009.00853.x;
RA   Ho C.S., Franzo-Romain M.H., Lee Y.J., Lee J.H., Smith D.M.;
RT   "Sequence-based characterization of swine leucocyte antigen alleles in
RT   commercially available porcine cell lines.";
RL   Int. J. Immunogenet. 36:231-234(2009).
//
RX   PubMed=20555413; DOI=10.1139/y10-023;
RA   Gunness P., Aleksa K., Kosuge K., Ito S., Koren G.;
RT   "Comparison of the novel HK-2 human renal proximal tubular cell line
RT   with the standard LLC-PK1 cell line in studying drug-induced
RT   nephrotoxicity.";
RL   Can. J. Physiol. Pharmacol. 88:448-455(2010).
//
RX   PubMed=33122286; DOI=10.1681/ASN.2020010009;
RA   Khundmiri S.J., Chen L.-H., Lederer E.D., Yang C.-R., Knepper M.A.;
RT   "Transcriptomes of major proximal tubule cell culture models.";
RL   J. Am. Soc. Nephrol. 32:86-97(2021).
//
RX   PubMed=34737324; DOI=10.1038/s41598-021-00779-5;
RA   Lung O., Candlish R.C., Nebroski M., Kruckiewicz P., Buchanan C.,
RA   Moniwa M.;
RT   "High-throughput sequencing for species authentication and
RT   contamination detection of 63 cell lines.";
RL   Sci. Rep. 11:21657-21657(2021).
//