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Cellosaurus LbetaT2 (CVCL_0398)

[Text version]
Cell line name LbetaT2
Synonyms L-beta-T2; L beta T2; Lbeta T2; L{beta}T2; Lbetat2; LbT2
Accession CVCL_0398
Resource Identification Initiative To cite this cell line use: LbetaT2 (RRID:CVCL_0398)
Comments Characteristics: Widely used as an in vitro model for the study of gonadotropin gene regulation and GnRH signaling (Millipore=SCC412).
Characteristics: Expresses CGA, GnRH-R and the alpha and beta subunits of LH (PubMed=8770922).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Pituitary gland; UBERON=UBERON_0000007.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6 x BALB/c transgenic.
Sex of cell Female
Category Transformed cell line
STR profile Source(s): Millipore

Markers:
Mouse STR 1-116,17
Mouse STR 1-219
Mouse STR 2-116
Mouse STR 3-213
Mouse STR 4-220.3,21.3
Mouse STR 5-513,17
Mouse STR 6-419,20
Mouse STR 6-712
Mouse STR 7-126.2
Mouse STR 8-116
Mouse STR 11-216,18
Mouse STR 12-116,17
Mouse STR 13-116.2
Mouse STR 15-322.3
Mouse STR 17-215
Mouse STR 18-316,17
Mouse STR 19-212
Mouse STR X-125

Run an STR similarity search on this cell line
Publications

PubMed=8770922; DOI=10.1210/endo.137.7.8770922
Thomas P., Mellon P.L., Turgeon J.L., Waring D.W.
The L beta T2 clonal gonadotrope: a model for single cell studies of endocrine cell secretion.
Endocrinology 137:2979-2989(1996)

PubMed=8898243; DOI=10.1242/dev.122.10.3319
Alarid E.T., Windle J.J., Whyte D.B., Mellon P.L.
Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice.
Development 122:3319-3329(1996)

PubMed=11356674; DOI=10.1210/endo.142.6.8185
Pernasetti F., Vasilyev V.V., Rosenberg S.B., Bailey J.S., Huang H.-J., Miller W.L., Mellon P.L.
Cell-specific transcriptional regulation of follicle-stimulating hormone-beta by activin and gonadotropin-releasing hormone in the LbetaT2 pituitary gonadotrope cell model.
Endocrinology 142:2284-2295(2001)

PubMed=15541569; DOI=10.1016/j.mce.2004.07.018
Ooi G.T., Tawadros N., Escalona R.M.
Pituitary cell lines and their endocrine applications.
Mol. Cell. Endocrinol. 228:1-21(2004)

PubMed=31020055; DOI=10.1210/js.2019-00064
Ruf-Zamojski F., Ge Y.-C., Pincas H., Shan J.-D., Song Y.-H., Hines N., Kelley K., Montagna C., Nair P., Toufaily C., Bernard D.J., Mellon P.L., Nair V., Turgeon J.L., Sealfon S.C.
Cytogenetic, genomic, and functional characterization of pituitary gonadotrope cell lines.
J. Endocr. Soc. 3:902-920(2019)

Cross-references
Cell line collections (Providers) Millipore; SCC412
Cell line databases/resources MCCL; MCC:0000292
Lonza; 1263
TOKU-E; 4079
Anatomy/cell type resources BTO; BTO:0004467
Encyclopedic resources Wikidata; Q54902109
Experimental variables resources EFO; EFO_0002070
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number17