ID   LbetaT2
AC   CVCL_0398
SY   L-beta-T2; L beta T2; Lbeta T2; L{beta}T2; Lbetat2; LbT2
DR   BTO; BTO:0004467
DR   EFO; EFO_0002070
DR   MCCL; MCC:0000292
DR   Lonza; 1263
DR   Millipore; SCC412
DR   TOKU-E; 4079
DR   Wikidata; Q54902109
RX   PubMed=8770922;
RX   PubMed=8898243;
RX   PubMed=11356674;
RX   PubMed=15541569;
RX   PubMed=31020055;
CC   Characteristics: Widely used as an in vitro model for the study of gonadotropin gene regulation and GnRH signaling (Millipore).
CC   Characteristics: Expresses CGA, GnRH-R and the alpha and beta subunits of LH (PubMed=8770922).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from sampling site: Pituitary gland.
CC   Breed/subspecies: C57BL/6 x BALB/c.
ST   Source(s): Millipore
ST   Mouse STR 1-1: 16,17
ST   Mouse STR 1-2: 19
ST   Mouse STR 11-2: 16,18
ST   Mouse STR 12-1: 16,17
ST   Mouse STR 13-1: 16.2
ST   Mouse STR 15-3: 22.3
ST   Mouse STR 17-2: 15
ST   Mouse STR 18-3: 16,17
ST   Mouse STR 19-2: 12
ST   Mouse STR 2-1: 16
ST   Mouse STR 3-2: 13
ST   Mouse STR 4-2: 20.3,21.3
ST   Mouse STR 5-5: 13,17
ST   Mouse STR 6-4: 19,20
ST   Mouse STR 6-7: 12
ST   Mouse STR 7-1: 26.2
ST   Mouse STR 8-1: 16
ST   Mouse STR X-1: 25
OX   NCBI_TaxID=10090; ! Mus musculus
SX   Female
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 23-09-21; Version: 14
//
RX   PubMed=8770922; DOI=10.1210/endo.137.7.8770922;
RA   Thomas P., Mellon P.L., Turgeon J., Waring D.W.;
RT   "The L beta T2 clonal gonadotrope: a model for single cell studies of
RT   endocrine cell secretion.";
RL   Endocrinology 137:2979-2989(1996).
//
RX   PubMed=8898243; DOI=10.1242/dev.122.10.3319;
RA   Alarid E.T., Windle J.J., Whyte D.B., Mellon P.L.;
RT   "Immortalization of pituitary cells at discrete stages of development
RT   by directed oncogenesis in transgenic mice.";
RL   Development 122:3319-3329(1996).
//
RX   PubMed=11356674; DOI=10.1210/endo.142.6.8185;
RA   Pernasetti F., Vasilyev V.V., Rosenberg S.B., Bailey J.S., Huang H.-J.,
RA   Miller W.L., Mellon P.L.;
RT   "Cell-specific transcriptional regulation of follicle-stimulating
RT   hormone-beta by activin and gonadotropin-releasing hormone in the
RT   LbetaT2 pituitary gonadotrope cell model.";
RL   Endocrinology 142:2284-2295(2001).
//
RX   PubMed=15541569; DOI=10.1016/j.mce.2004.07.018;
RA   Ooi G.T., Tawadros N., Escalona R.M.;
RT   "Pituitary cell lines and their endocrine applications.";
RL   Mol. Cell. Endocrinol. 228:1-21(2004).
//
RX   PubMed=31020055; DOI=10.1210/js.2019-00064;
RA   Ruf-Zamojski F., Ge Y.-C., Pincas H., Shan J.-D., Song Y.-H., Hines N.,
RA   Kelley K., Montagna C., Nair P., Toufaily C., Bernard D.J.,
RA   Mellon P.L., Nair V., Turgeon J.L., Sealfon S.C.;
RT   "Cytogenetic, genomic, and functional characterization of pituitary
RT   gonadotrope cell lines.";
RL   J. Endocr. Soc. 3:902-920(2019).
//